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DROME:GRK
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | grk | |
| Protein Name(s) | Protein gurken | |
| External Links | ||
| UniProt | P42287 | |
| EMBL | L22531 AF223394 AE014134 AY051814 | |
| PIR | A48844 | |
| RefSeq | NP_476568.2 | |
| UniGene | Dm.355 | |
| ProteinModelPortal | P42287 | |
| SMR | P42287 | |
| BioGrid | 60293 | |
| DIP | DIP-20922N | |
| IntAct | P42287 | |
| MINT | MINT-320623 | |
| STRING | 7227.FBpp0079313 | |
| EnsemblMetazoa | FBtr0079708 | |
| GeneID | 34171 | |
| KEGG | dme:Dmel_CG17610 | |
| UCSC | CG17610-RA | |
| CTD | 34171 | |
| FlyBase | FBgn0001137 | |
| eggNOG | NOG329056 | |
| InParanoid | P42287 | |
| KO | K02447 | |
| OMA | QQLHLHK | |
| OrthoDB | EOG7S4X7H | |
| PhylomeDB | P42287 | |
| SignaLink | P42287 | |
| GenomeRNAi | 34171 | |
| NextBio | 787225 | |
| PMAP-CutDB | P42287 | |
| Proteomes | UP000000803 | |
| Bgee | P42287 | |
| GO | GO:0005783 GO:0005576 GO:0000139 GO:0016021 GO:0005886 GO:0005154 GO:0030714 GO:0009952 GO:0007298 GO:0090110 GO:0001709 GO:0001708 GO:0030381 GO:0046843 GO:0008069 GO:0000578 GO:0007173 GO:0030722 GO:0008314 GO:0008070 GO:0007314 GO:0007309 GO:0007310 GO:0016325 | |
| InterPro | IPR000742 IPR013032 | |
| SMART | SM00181 | |
| PROSITE | PS00022 PS50026 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0020224 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0020248 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046843 |
dorsal appendage formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903688 |
positive regulation of border follicle cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016325 |
oocyte microtubule cytoskeleton organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007310 |
oocyte dorsal/ventral axis specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903688 |
positive regulation of border follicle cell migration |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0020224 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007298 |
border follicle cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030381 |
chorion-containing eggshell pattern formation |
ECO:0007001 |
high throughput mutant phenotypic evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008070 |
maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0051702 |
interaction with symbiont |
ECO:0000314 |
P |
Fig.1,Wolbachia titer is affected by the host grk gene in stage 10A oocytes.Fig.2. Host grk dosage affects Wolbachia titer in stage 10A nurse cells.Fig.3.Wolbachia titer is affected by grk at stage 2–3 of oogenesis |
complete | |||||
|
enables |
GO:0005154 |
epidermal growth factor receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_input:(FB:FBgn0003731) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046843 |
dorsal appendage formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048018 |
receptor ligand activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0005154 |
epidermal growth factor receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048263 |
determination of dorsal identity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007474 |
imaginal disc-derived wing vein specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046843 |
dorsal appendage formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0003205 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0048018 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030714 |
anterior/posterior axis specification, follicular epithelium |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007314 |
oocyte anterior/posterior axis specification |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007310 |
oocyte dorsal/ventral axis specification |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008069 |
dorsal/ventral axis specification, ovarian follicular epithelium |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009952 |
anterior/posterior pattern specification |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048477 |
oogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Bökel, C et al. (2006) Drosophila Cornichon acts as cargo receptor for ER export of the TGFalpha-like growth factor Gurken. Development 133 459-70 PubMed GONUTS page
- ↑ Pai, LM et al. (2000) D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis. Cell 103 51-61 PubMed GONUTS page
- ↑ Guichard, A et al. (2000) brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Dev. Biol. 226 255-66 PubMed GONUTS page
- ↑ Niepielko, MG & Yakoby, N (2014) Evolutionary changes in TGFα distribution underlie morphological diversity in eggshells from Drosophila species. Development 141 4710-5 PubMed GONUTS page
- ↑ McDonald, JA et al. (2006) Multiple EGFR ligands participate in guiding migrating border cells. Dev. Biol. 296 94-103 PubMed GONUTS page
- ↑ Januschke, J et al. (2006) The centrosome-nucleus complex and microtubule organization in the Drosophila oocyte. Development 133 129-39 PubMed GONUTS page
- ↑ Cáceres, L & Nilson, LA (2005) Production of gurken in the nurse cells is sufficient for axis determination in the Drosophila oocyte. Development 132 2345-53 PubMed GONUTS page
- ↑ Jékely, G et al. (2005) Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev. Cell 9 197-207 PubMed GONUTS page
- ↑ Duchek, P & Rørth, P (2001) Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis. Science 291 131-3 PubMed GONUTS page
- ↑ Schüpbach, T & Wieschaus, E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129 1119-36 PubMed GONUTS page
- ↑ Schüpbach, T (1987) Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster. Cell 49 699-707 PubMed GONUTS page
- ↑ Serbus, LR et al. (2011) A feedback loop between Wolbachia and the Drosophila gurken mRNP complex influences Wolbachia titer. J. Cell. Sci. 124 4299-308 PubMed GONUTS page
- ↑ 13.0 13.1 Shmueli, A et al. (2002) Gurken, a TGF-alpha-like protein involved in axis determination in Drosophila, directly binds to the EGF-receptor homolog Egfr. Biochem. Biophys. Res. Commun. 291 732-7 PubMed GONUTS page
- ↑ Wasserman, JD & Freeman, M (1998) An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95 355-64 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 15.4 15.5 15.6 Ghiglione, C et al. (2002) Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development 129 175-86 PubMed GONUTS page
- ↑ Schnorr, JD & Berg, CA (1996) Differential activity of Ras1 during patterning of the Drosophila dorsoventral axis. Genetics 144 1545-57 PubMed GONUTS page
- ↑ Denef, N & Schüpbach, T (2003) Patterning: JAK-STAT signalling in the Drosophila follicular epithelium. Curr. Biol. 13 R388-90 PubMed GONUTS page
- ↑ 18.0 18.1 Farina, KL & Singer, RH (2002) The nuclear connection in RNA transport and localization. Trends Cell Biol. 12 466-72 PubMed GONUTS page
- ↑ Mahowald, AP (2001) Assembly of the Drosophila germ plasm. Int. Rev. Cytol. 203 187-213 PubMed GONUTS page
- ↑ 20.0 20.1 van Eeden, F & St Johnston, D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr. Opin. Genet. Dev. 9 396-404 PubMed GONUTS page
- ↑ Martín-Blanco, E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22 637-45 PubMed GONUTS page
- ↑ Dobens, LL & Raftery, LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev. Dyn. 218 80-93 PubMed GONUTS page
- ↑ Wylie, C (1999) Germ cells. Cell 96 165-74 PubMed GONUTS page
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