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Serbus, LR, Ferreccio, A, Zhukova, M, McMorris, CL, Kiseleva, E and Sullivan, W (2011) A feedback loop between Wolbachia and the Drosophila gurken mRNP complex influences Wolbachia titer. J. Cell. Sci. 124:4299-308


Although much is known about interactions between bacterial endosymbionts and their hosts, little is known concerning the host factors that influence endosymbiont titer. Wolbachia endosymbionts are globally dispersed throughout most insect species and are the causative agent in filarial nematode-mediated disease. Our investigation indicates that gurken (grk), a host gene encoding a crucial axis determinant, has a cumulative, dosage-sensitive impact on Wolbachia growth and proliferation during Drosophila oogenesis. This effect appears to be mediated by grk mRNA and its protein-binding partners Squid and Hrp48/Hrb27C, implicating the grk mRNA-protein (mRNP) complex as a rate-limiting host factor controlling Wolbachia titer. Furthermore, highly infected flies exhibit defects that match those occurring with disruption of grk mRNPs, such as nurse cell chromatin disruptions and malformation of chorionic appendages. These findings suggest a feedback loop in which Wolbachia interaction with the grk mRNP affects both Wolbachia titer and grk mRNP function.


PubMed PMC3258112 Online version:10.1242/jcs.092510


Animals; Drosophila Proteins/analysis; Drosophila Proteins/genetics; Drosophila melanogaster/genetics; Drosophila melanogaster/microbiology; Drosophila melanogaster/ultrastructure; Feedback, Physiological; Microtubules/physiology; Oocytes/microbiology; Oocytes/ultrastructure; Oogenesis; RNA-Binding Proteins/analysis; Ribonucleoproteins/physiology; Symbiosis; Transforming Growth Factor alpha/genetics; Wolbachia/physiology; Wolbachia/ultrastructure



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status


GO:0051702: interaction with symbiont



Fig.1,Wolbachia titer is affected by the host grk gene in stage 10A oocytes.Fig.2. Host grk dosage affects Wolbachia titer in stage 10A nurse cells.Fig.3.Wolbachia titer is affected by grk at stage 2–3 of oogenesis

CACAO 8130

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