DROME:FMR1

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Fmr1 (ECO:0000312 with EMBL:AAF14639.1) (synonyms: FXR (ECO:0000312 with EMBL:CAB66340.1))
Protein Name(s)	Fragile X mental retardation syndrome-related protein 1 dFMR1 dfxr
External Links
UniProt	Q9NFU0
EMBL	AF305881 AF205596 AF205597 AJ271221 AJ413217 AJ422082 AJ422083 AE014297 AE014297 AE014297 AE014297 AE014297 AY069182 BT031124
RefSeq	NP_611645.1 NP_731443.1 NP_731444.1 NP_731445.1 NP_731446.1
UniGene	Dm.5279
ProteinModelPortal	Q9NFU0
SMR	Q9NFU0
BioGrid	63147
IntAct	Q9NFU0
MINT	MINT-248306
STRING	7227.FBpp0081675
PaxDb	Q9NFU0
PRIDE	Q9NFU0
EnsemblMetazoa	FBtr0082197
GeneID	37528
KEGG	dme:Dmel_CG6203
UCSC	CG6203-RD
CTD	2332
FlyBase	FBgn0028734
eggNOG	NOG75351
GeneTree	ENSGT00390000017033
InParanoid	Q9NFU0
KO	K15516
OrthoDB	EOG7NKKJT
PhylomeDB	Q9NFU0
ChiTaRS	Fmr1
GenomeRNAi	37528
NextBio	804110
Proteomes	UP000000803
Bgee	Q9NFU0
ExpressionAtlas	Q9NFU0
GO	GO:0005737 GO:0005811 GO:0035068 GO:0016442 GO:0042802 GO:0043621 GO:0003723 GO:0007411 GO:0007413 GO:0007409 GO:0007420 GO:0007349 GO:0007623 GO:0050802 GO:0048813 GO:0050976 GO:0031047 GO:0007281 GO:0048134 GO:0007294 GO:0046959 GO:0031507 GO:0008345 GO:0040011 GO:0045475 GO:0007616 GO:0008049 GO:0045448 GO:0051028 GO:0016319 GO:0050774 GO:0045571 GO:0051964 GO:0045886 GO:0017148 GO:0007528 GO:0048812 GO:0008355 GO:0007310 GO:0007279 GO:0042127 GO:0048814 GO:0009794 GO:0090328 GO:0050807 GO:0051823 GO:0006417 GO:0007614 GO:0007288 GO:0007416 GO:0050808 GO:0007601
Gene3D	3.30.1370.10
InterPro	IPR008395 IPR004087 IPR004088 IPR022967
Pfam	PF00013
SMART	SM00322 SM00316
SUPFAM	SSF54791
PROSITE	PS51641 PS50084

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0045182	translation regulator activity	PMID:11733059^[1]	ECO:0000315			F	Figure 3, 4, 5, 6, 8. dfxr Overexpression Lines and Nulls Display Postural and Locomotive Defects as Viable Adults; Overexpression and Loss-of-Function of dFXR Gave Rise to Structural and Functional Eye Phenotypes; dfxr Mutants and Overexpression Lines Differentially Affect Synaptic Growth and Structure; Figure 6. dfxr Nulls and Overexpression Lines Differently Affect Evoked and Spontaneous Neurotransmission; Synaptic Phenotypes of dfxr Nulls Are Suppressed by futsch Mutants	complete CACAO 3434
part_of	GO:0071598	neuronal ribonucleoprotein granule	PMID:17178403^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	PMID:17178403^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23128	F	Seeded From UniProt	complete
part_of	GO:1990124	messenger ribonucleoprotein complex	PMID:17178403^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0045182	translation regulator activity	PMID:11733059^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	PMID:14508492^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1905244	regulation of modification of synaptic structure	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980	P	Seeded From UniProt	complete
involved_in	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980	P	Seeded From UniProt	complete
part_of	GO:0071598	neuronal ribonucleoprotein granule	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 MGI:MGI:95564 PANTHER:PTN000063980 RGD:2623	C	Seeded From UniProt	complete
involved_in	GO:0060998	regulation of dendritic spine development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980 UniProtKB:Q06787	P	Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 PANTHER:PTN000063980	P	Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318100 UniProtKB:Q06787	P	Seeded From UniProt	complete
enables	GO:0045182	translation regulator activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 PANTHER:PTN001318100	F	Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318100	P	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN000063980 RGD:2623	C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 PANTHER:PTN000063980 RGD:2623	C	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001318100 UniProtKB:P51114 UniProtKB:P51116 UniProtKB:Q06787	F	Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318100 RGD:2623 UniProtKB:Q06787	C	Seeded From UniProt	complete
part_of	GO:0035770	ribonucleoprotein granule	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN000063980 RGD:2623	C	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100	P	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000063980 RGD:2623	C	Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980	P	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN000063980	P	Seeded From UniProt	complete
part_of	GO:0005844	polysome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:1346074 MGI:MGI:95564 PANTHER:PTN001318100 RGD:2623 UniProtKB:Q06787	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028734 MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100 UniProtKB:P51116 UniProtKB:Q06787	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100 RGD:2623 UniProtKB:Q06787 Xenbase:XB-GENE-1004708 Xenbase:XB-GENE-977113	C	Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104860 MGI:MGI:95564 PANTHER:PTN001318100 UniProtKB:Q06787	F	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95564 PANTHER:PTN001318100 RGD:2623 UniProtKB:Q06787	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:12368261^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NFU0	F	Seeded From UniProt	complete
part_of	GO:0071598	neuronal ribonucleoprotein granule	PMID:26385636^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0072375	medium-term memory	PMID:25921541^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046959	habituation	PMID:24344294^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:24344294^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0007614	short-term memory	PMID:24344294^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090328	regulation of olfactory learning	PMID:24344294^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900073	regulation of neuromuscular synaptic transmission	PMID:24046358^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045571	negative regulation of imaginal disc growth	PMID:23874212^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015778	P	Seeded From UniProt	complete
involved_in	GO:0045571	negative regulation of imaginal disc growth	PMID:23874212^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0042134	P	Seeded From UniProt	complete
involved_in	GO:0045571	negative regulation of imaginal disc growth	PMID:23874212^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0020279	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23874212^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:23666178^[11]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0033159	F	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:23666178^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:23666178^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050976	detection of mechanical stimulus involved in sensory perception of touch	PMID:23666178^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	PMID:23666178^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	PMID:23439121^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:22993428^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	PMID:22993428^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	PMID:22513101^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:22513101^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008355	olfactory learning	PMID:22080836^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051964	negative regulation of synapse assembly	PMID:22080836^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	PMID:22087250^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008049	male courtship behavior	PMID:22087250^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007625	grooming behavior	PMID:22087250^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035176	social behavior	PMID:20519966^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:21669931^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043068	positive regulation of programmed cell death	PMID:21596027^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009794	regulation of mitotic cell cycle, embryonic	PMID:21068064^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0042134	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21068064^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007349	cellularization	PMID:21068064^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0042134	P	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:20442204^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007614	short-term memory	PMID:20463240^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008049	male courtship behavior	PMID:20463240^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:20463240^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:20463240^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051823	regulation of synapse structural plasticity	PMID:19738924^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048134	germ-line cyst formation	PMID:19306863^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0020224	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:19306863^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0020224	P	Seeded From UniProt	complete
involved_in	GO:0048134	germ-line cyst formation	PMID:19306863^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:19306863^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	PMID:19343200^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0262451	P	Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	PMID:18655836^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050802	circadian sleep/wake cycle, sleep	PMID:19228950^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	PMID:19005053^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008355	olfactory learning	PMID:18776892^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:18776892^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070142	synaptic vesicle budding	PMID:18280750^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	PMID:18280750^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:18354025^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007528	neuromuscular junction development	PMID:18354025^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007349	cellularization	PMID:17110444^[32]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031507	heterochromatin assembly	PMID:16888325^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007279	pole cell formation	PMID:16888325^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045448	mitotic cell cycle, embryonic	PMID:16949822^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007279	pole cell formation	PMID:16949822^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:15964283^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007413	axonal fasciculation	PMID:15964283^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:15964283^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051964	negative regulation of synapse assembly	PMID:15621528^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007294	germarium-derived oocyte fate determination	PMID:15737929^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007310	oocyte dorsal/ventral axis specification	PMID:15737929^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004882	P	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	PMID:15737929^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	PMID:15737929^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050774	negative regulation of dendrite morphogenesis	PMID:15498496^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:15498496^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008345	larval locomotory behavior	PMID:15202995^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016319	mushroom body development	PMID:15215302^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007288	sperm axoneme assembly	PMID:15183715^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048814	regulation of dendrite morphogenesis	PMID:14530299^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:12818175^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:12818175^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0038320	P	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:12818175^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:12818175^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0038320	P	Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:11879765^[44]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	PMID:11879765^[44]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:12446764^[45]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:12446764^[45]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	PMID:12368260^[46]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0087035	C	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:12176363^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0006935	chemotaxis	PMID:12086644^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:12086644^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0042331	phototaxis	PMID:12086644^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:12086643^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0007268	chemical synaptic transmission	PMID:12086643^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:12086643^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:11733059^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:11733059^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900364	negative regulation of mRNA polyadenylation	PMID:28793261^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:28793261^[50]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:28793261^[50]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032838	plasma membrane bounded cell projection cytoplasm	PMID:28793261^[50]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0072553	terminal button organization	PMID:28073926^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:28073926^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:28073926^[51]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1990834	response to odorant	PMID:28366741^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042048	olfactory behavior	PMID:28366741^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0098883	synapse pruning	PMID:18321984^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:18321984^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	PMID:18321984^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045886	negative regulation of synaptic growth at neuromuscular junction	PMID:25908854^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:25908854^[54]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	PMID:25908854^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C	Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008089	C	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004087	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004088 InterPro:IPR022034 InterPro:IPR036612	F	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040148	F	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040148	P	Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	PMID:15145345^[55] PMID:14559182^[56]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0035068	micro-ribonucleoprotein complex	PMID:14559182^[56]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	PMID:12633995^[57]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008049	male courtship behavior	PMID:12633995^[57]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:12633995^[57]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C	Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966 UniProtKB-SubCell:SL-0280	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0844	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C	Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0496	C	Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0495	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zhang, YQ et al. (2001) Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107 591-603 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Barbee, SA et al. (2006) Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies. Neuron 52 997-1009 PubMed GONUTS page
↑ Caudy, AA et al. (2003) A micrococcal nuclease homologue in RNAi effector complexes. Nature 425 411-4 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ishizuka, A et al. (2002) A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev. 16 2497-508 PubMed GONUTS page
↑ Coyne, AN et al. (2015) Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation. Hum. Mol. Genet. 24 6886-98 PubMed GONUTS page
↑ Gross, C et al. (2015) Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. Cell Rep 11 727-36 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Sudhakaran, IP et al. (2014) FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control. Proc. Natl. Acad. Sci. U.S.A. 111 E99-E108 PubMed GONUTS page
↑ Friedman, SH et al. (2013) Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Dis Model Mech 6 1400-13 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Baumgartner, R et al. (2013) The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster. PLoS Genet. 9 e1003598 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Cvetkovska, V et al. (2013) Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting. Nat. Neurosci. 16 677-82 PubMed GONUTS page
↑ Nahm, M et al. (2013) Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization. Neuron 77 680-95 PubMed GONUTS page
↑ ^13.0 ^13.1 Kanellopoulos, AK et al. (2012) Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila. J. Neurosci. 32 13111-24 PubMed GONUTS page
↑ ^14.0 ^14.1 Callan, MA et al. (2012) Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. Brain Res. 1462 151-61 PubMed GONUTS page
↑ ^15.0 ^15.1 Coffee, RL Jr et al. (2012) In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation. Hum. Mol. Genet. 21 900-15 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Tauber, JM et al. (2011) Elevated levels of the vesicular monoamine transporter and a novel repetitive behavior in the Drosophila model of fragile X syndrome. PLoS ONE 6 e27100 PubMed GONUTS page
↑ Bolduc, FV et al. () An assay for social interaction in Drosophila fragile X mutants. Fly (Austin) 4 216-25 PubMed GONUTS page
↑ Siller, SS & Broadie, K (2011) Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. Dis Model Mech 4 673-85 PubMed GONUTS page
↑ Gatto, CL & Broadie, K (2011) Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons. Dev. Biol. 356 291-307 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Papoulas, O et al. (2010) dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition. Development 137 4201-9 PubMed GONUTS page
↑ Coffee, RL Jr et al. () Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. Dis Model Mech 3 471-85 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Banerjee, P et al. (2010) Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein. J. Neurosci. 30 6782-92 PubMed GONUTS page
↑ Gatto, CL & Broadie, K (2009) Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture. Front Neural Circuits 3 8 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Epstein, AM et al. (2009) Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Dev. Biol. 330 83-92 PubMed GONUTS page
↑ Yang, Y et al. (2009) The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genet. 5 e1000444 PubMed GONUTS page
↑ Estes, PS et al. (2008) Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons. Mol. Cell. Neurosci. 39 170-9 PubMed GONUTS page
↑ Bushey, D et al. (2009) The Drosophila fragile X mental retardation gene regulates sleep need. J. Neurosci. 29 1948-61 PubMed GONUTS page
↑ Xu, XL et al. (2008) The steady-state level of the nervous-system-specific microRNA-124a is regulated by dFMR1 in Drosophila. J. Neurosci. 28 11883-9 PubMed GONUTS page
↑ ^29.0 ^29.1 Bolduc, FV et al. (2008) Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory. Nat. Neurosci. 11 1143-5 PubMed GONUTS page
↑ ^30.0 ^30.1 Pan, L et al. (2008) Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling. Mol. Cell. Neurosci. 37 747-60 PubMed GONUTS page
↑ ^31.0 ^31.1 Reeve, SP et al. (2008) Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. J. Neurosci. 28 3221-6 PubMed GONUTS page
↑ Monzo, K et al. (2006) Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos. Proc. Natl. Acad. Sci. U.S.A. 103 18160-5 PubMed GONUTS page
↑ ^33.0 ^33.1 Deshpande, G et al. (2006) The drosophila fragile X protein dFMR1 is required during early embryogenesis for pole cell formation and rapid nuclear division cycles. Genetics 174 1287-98 PubMed GONUTS page
↑ ^34.0 ^34.1 Megosh, HB et al. (2006) The role of PIWI and the miRNA machinery in Drosophila germline determination. Curr. Biol. 16 1884-94 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Reeve, SP et al. (2005) The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr. Biol. 15 1156-63 PubMed GONUTS page
↑ Zarnescu, DC et al. (2005) Fragile X protein functions with lgl and the par complex in flies and mice. Dev. Cell 8 43-52 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 ^37.3 Costa, A et al. (2005) The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev. Cell 8 331-42 PubMed GONUTS page
↑ ^38.0 ^38.1 Pan, L et al. (2004) The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Curr. Biol. 14 1863-70 PubMed GONUTS page
↑ Xu, K et al. (2004) The fragile X-related gene affects the crawling behavior of Drosophila larvae by regulating the mRNA level of the DEG/ENaC protein pickpocket1. Curr. Biol. 14 1025-34 PubMed GONUTS page
↑ Michel, CI et al. (2004) Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants. J. Neurosci. 24 5798-809 PubMed GONUTS page
↑ Zhang, YQ et al. (2004) The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Dev. Biol. 270 290-307 PubMed GONUTS page
↑ Lee, A et al. (2003) Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1. Development 130 5543-52 PubMed GONUTS page
↑ ^43.0 ^43.1 ^43.2 ^43.3 Schenck, A et al. (2003) CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Neuron 38 887-98 PubMed GONUTS page
↑ ^44.0 ^44.1 Oostra, BA (2002) Functions of the fragile X protein. Trends Mol Med 8 102-3 PubMed GONUTS page
↑ ^45.0 ^45.1 Siomi, MC et al. (2002) Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties. Mol. Cell. Biol. 22 8438-47 PubMed GONUTS page
↑ Caudy, AA et al. (2002) Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 16 2491-6 PubMed GONUTS page
↑ Inoue, S et al. (2002) A role for the Drosophila fragile X-related gene in circadian output. Curr. Biol. 12 1331-5 PubMed GONUTS page
↑ ^48.0 ^48.1 ^48.2 Dockendorff, TC et al. (2002) Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron 34 973-84 PubMed GONUTS page
↑ ^49.0 ^49.1 ^49.2 Morales, J et al. (2002) Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron 34 961-72 PubMed GONUTS page
↑ ^50.0 ^50.1 ^50.2 ^50.3 Bienkowski, RS et al. (2017) The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons. Cell Rep 20 1372-1384 PubMed GONUTS page
↑ ^51.0 ^51.1 ^51.2 Zhang, XY et al. (2017) Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction. Hum. Mol. Genet. 26 955-968 PubMed GONUTS page
↑ ^52.0 ^52.1 Franco, LM et al. (2017) Reduced Lateral Inhibition Impairs Olfactory Computations and Behaviors in a Drosophila Model of Fragile X Syndrome. Curr. Biol. 27 1111-1123 PubMed GONUTS page
↑ ^53.0 ^53.1 ^53.2 Tessier, CR & Broadie, K (2008) Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development 135 1547-57 PubMed GONUTS page
↑ ^54.0 ^54.1 ^54.2 Bozzetti, MP et al. (2015) The Drosophila fragile X mental retardation protein participates in the piRNA pathway. J. Cell. Sci. 128 2070-84 PubMed GONUTS page
↑ Murchison, EP & Hannon, GJ (2004) miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr. Opin. Cell Biol. 16 223-9 PubMed GONUTS page
↑ ^56.0 ^56.1 Nelson, P et al. (2003) The microRNA world: small is mighty. Trends Biochem. Sci. 28 534-40 PubMed GONUTS page
↑ ^57.0 ^57.1 ^57.2 Jin, P & Warren, ST (2003) New insights into fragile X syndrome: from molecules to neurobehaviors. Trends Biochem. Sci. 28 152-8 PubMed GONUTS page

[PMID:11733059-1] 1.0 ^1.1 ^1.2 ^1.3 Zhang, YQ et al. (2001) Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107 591-603 PubMed GONUTS page

[PMID:17178403-2] 2.0 ^2.1 ^2.2 Barbee, SA et al. (2006) Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies. Neuron 52 997-1009 PubMed GONUTS page

[PMID:14508492-3] Caudy, AA et al. (2003) A micrococcal nuclease homologue in RNAi effector complexes. Nature 425 411-4 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12368261-5] Ishizuka, A et al. (2002) A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev. 16 2497-508 PubMed GONUTS page

[PMID:26385636-6] Coyne, AN et al. (2015) Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation. Hum. Mol. Genet. 24 6886-98 PubMed GONUTS page

[PMID:25921541-7] Gross, C et al. (2015) Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. Cell Rep 11 727-36 PubMed GONUTS page

[PMID:24344294-8] 8.0 ^8.1 ^8.2 ^8.3 Sudhakaran, IP et al. (2014) FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control. Proc. Natl. Acad. Sci. U.S.A. 111 E99-E108 PubMed GONUTS page

[PMID:24046358-9] Friedman, SH et al. (2013) Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Dis Model Mech 6 1400-13 PubMed GONUTS page

[PMID:23874212-10] 10.0 ^10.1 ^10.2 ^10.3 Baumgartner, R et al. (2013) The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster. PLoS Genet. 9 e1003598 PubMed GONUTS page

[PMID:23666178-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Cvetkovska, V et al. (2013) Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting. Nat. Neurosci. 16 677-82 PubMed GONUTS page

[PMID:23439121-12] Nahm, M et al. (2013) Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization. Neuron 77 680-95 PubMed GONUTS page

[PMID:22993428-13] 13.0 ^13.1 Kanellopoulos, AK et al. (2012) Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila. J. Neurosci. 32 13111-24 PubMed GONUTS page

[PMID:22513101-14] 14.0 ^14.1 Callan, MA et al. (2012) Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. Brain Res. 1462 151-61 PubMed GONUTS page

[PMID:22080836-15] 15.0 ^15.1 Coffee, RL Jr et al. (2012) In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation. Hum. Mol. Genet. 21 900-15 PubMed GONUTS page

[PMID:22087250-16] 16.0 ^16.1 ^16.2 Tauber, JM et al. (2011) Elevated levels of the vesicular monoamine transporter and a novel repetitive behavior in the Drosophila model of fragile X syndrome. PLoS ONE 6 e27100 PubMed GONUTS page

[PMID:20519966-17] Bolduc, FV et al. () An assay for social interaction in Drosophila fragile X mutants. Fly (Austin) 4 216-25 PubMed GONUTS page

[PMID:21669931-18] Siller, SS & Broadie, K (2011) Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. Dis Model Mech 4 673-85 PubMed GONUTS page

[PMID:21596027-19] Gatto, CL & Broadie, K (2011) Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons. Dev. Biol. 356 291-307 PubMed GONUTS page

[PMID:21068064-20] 20.0 ^20.1 ^20.2 Papoulas, O et al. (2010) dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition. Development 137 4201-9 PubMed GONUTS page

[PMID:20442204-21] Coffee, RL Jr et al. () Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. Dis Model Mech 3 471-85 PubMed GONUTS page

[PMID:20463240-22] 22.0 ^22.1 ^22.2 ^22.3 Banerjee, P et al. (2010) Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein. J. Neurosci. 30 6782-92 PubMed GONUTS page

[PMID:19738924-23] Gatto, CL & Broadie, K (2009) Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture. Front Neural Circuits 3 8 PubMed GONUTS page

[PMID:19306863-24] 24.0 ^24.1 ^24.2 ^24.3 Epstein, AM et al. (2009) Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Dev. Biol. 330 83-92 PubMed GONUTS page

[PMID:19343200-25] Yang, Y et al. (2009) The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genet. 5 e1000444 PubMed GONUTS page

[PMID:18655836-26] Estes, PS et al. (2008) Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons. Mol. Cell. Neurosci. 39 170-9 PubMed GONUTS page

[PMID:19228950-27] Bushey, D et al. (2009) The Drosophila fragile X mental retardation gene regulates sleep need. J. Neurosci. 29 1948-61 PubMed GONUTS page

[PMID:19005053-28] Xu, XL et al. (2008) The steady-state level of the nervous-system-specific microRNA-124a is regulated by dFMR1 in Drosophila. J. Neurosci. 28 11883-9 PubMed GONUTS page

[PMID:18776892-29] 29.0 ^29.1 Bolduc, FV et al. (2008) Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory. Nat. Neurosci. 11 1143-5 PubMed GONUTS page

[PMID:18280750-30] 30.0 ^30.1 Pan, L et al. (2008) Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling. Mol. Cell. Neurosci. 37 747-60 PubMed GONUTS page

[PMID:18354025-31] 31.0 ^31.1 Reeve, SP et al. (2008) Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. J. Neurosci. 28 3221-6 PubMed GONUTS page

[PMID:17110444-32] Monzo, K et al. (2006) Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos. Proc. Natl. Acad. Sci. U.S.A. 103 18160-5 PubMed GONUTS page

[PMID:16888325-33] 33.0 ^33.1 Deshpande, G et al. (2006) The drosophila fragile X protein dFMR1 is required during early embryogenesis for pole cell formation and rapid nuclear division cycles. Genetics 174 1287-98 PubMed GONUTS page

[PMID:16949822-34] 34.0 ^34.1 Megosh, HB et al. (2006) The role of PIWI and the miRNA machinery in Drosophila germline determination. Curr. Biol. 16 1884-94 PubMed GONUTS page

[PMID:15964283-35] 35.0 ^35.1 ^35.2 Reeve, SP et al. (2005) The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr. Biol. 15 1156-63 PubMed GONUTS page

[PMID:15621528-36] Zarnescu, DC et al. (2005) Fragile X protein functions with lgl and the par complex in flies and mice. Dev. Cell 8 43-52 PubMed GONUTS page

[PMID:15737929-37] 37.0 ^37.1 ^37.2 ^37.3 Costa, A et al. (2005) The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev. Cell 8 331-42 PubMed GONUTS page

[PMID:15498496-38] 38.0 ^38.1 Pan, L et al. (2004) The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Curr. Biol. 14 1863-70 PubMed GONUTS page

[PMID:15202995-39] Xu, K et al. (2004) The fragile X-related gene affects the crawling behavior of Drosophila larvae by regulating the mRNA level of the DEG/ENaC protein pickpocket1. Curr. Biol. 14 1025-34 PubMed GONUTS page

[PMID:15215302-40] Michel, CI et al. (2004) Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants. J. Neurosci. 24 5798-809 PubMed GONUTS page

[PMID:15183715-41] Zhang, YQ et al. (2004) The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Dev. Biol. 270 290-307 PubMed GONUTS page

[PMID:14530299-42] Lee, A et al. (2003) Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1. Development 130 5543-52 PubMed GONUTS page

[PMID:12818175-43] 43.0 ^43.1 ^43.2 ^43.3 Schenck, A et al. (2003) CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Neuron 38 887-98 PubMed GONUTS page

[PMID:11879765-44] 44.0 ^44.1 Oostra, BA (2002) Functions of the fragile X protein. Trends Mol Med 8 102-3 PubMed GONUTS page

[PMID:12446764-45] 45.0 ^45.1 Siomi, MC et al. (2002) Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties. Mol. Cell. Biol. 22 8438-47 PubMed GONUTS page

[PMID:12368260-46] Caudy, AA et al. (2002) Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 16 2491-6 PubMed GONUTS page

[PMID:12176363-47] Inoue, S et al. (2002) A role for the Drosophila fragile X-related gene in circadian output. Curr. Biol. 12 1331-5 PubMed GONUTS page

[PMID:12086644-48] 48.0 ^48.1 ^48.2 Dockendorff, TC et al. (2002) Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron 34 973-84 PubMed GONUTS page

[PMID:12086643-49] 49.0 ^49.1 ^49.2 Morales, J et al. (2002) Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron 34 961-72 PubMed GONUTS page

[PMID:28793261-50] 50.0 ^50.1 ^50.2 ^50.3 Bienkowski, RS et al. (2017) The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons. Cell Rep 20 1372-1384 PubMed GONUTS page

[PMID:28073926-51] 51.0 ^51.1 ^51.2 Zhang, XY et al. (2017) Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction. Hum. Mol. Genet. 26 955-968 PubMed GONUTS page

[PMID:28366741-52] 52.0 ^52.1 Franco, LM et al. (2017) Reduced Lateral Inhibition Impairs Olfactory Computations and Behaviors in a Drosophila Model of Fragile X Syndrome. Curr. Biol. 27 1111-1123 PubMed GONUTS page

[PMID:18321984-53] 53.0 ^53.1 ^53.2 Tessier, CR & Broadie, K (2008) Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development 135 1547-57 PubMed GONUTS page

[PMID:25908854-54] 54.0 ^54.1 ^54.2 Bozzetti, MP et al. (2015) The Drosophila fragile X mental retardation protein participates in the piRNA pathway. J. Cell. Sci. 128 2070-84 PubMed GONUTS page

[PMID:15145345-55] Murchison, EP & Hannon, GJ (2004) miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr. Opin. Cell Biol. 16 223-9 PubMed GONUTS page

[PMID:14559182-56] 56.0 ^56.1 Nelson, P et al. (2003) The microRNA world: small is mighty. Trends Biochem. Sci. 28 534-40 PubMed GONUTS page

[PMID:12633995-57] 57.0 ^57.1 ^57.2 Jin, P & Warren, ST (2003) New insights into fragile X syndrome: from molecules to neurobehaviors. Trends Biochem. Sci. 28 152-8 PubMed GONUTS page

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