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DROME:FMR1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Fmr1 (ECO:0000312 with EMBL:AAF14639.1) (synonyms: FXR (ECO:0000312 with EMBL:CAB66340.1))
Protein Name(s) Fragile X mental retardation syndrome-related protein 1

dFMR1 dfxr

External Links
UniProt Q9NFU0
EMBL AF305881
AF205596
AF205597
AJ271221
AJ413217
AJ422082
AJ422083
AE014297
AE014297
AE014297
AE014297
AE014297
AY069182
BT031124
RefSeq NP_611645.1
NP_731443.1
NP_731444.1
NP_731445.1
NP_731446.1
UniGene Dm.5279
ProteinModelPortal Q9NFU0
SMR Q9NFU0
BioGrid 63147
IntAct Q9NFU0
MINT MINT-248306
STRING 7227.FBpp0081675
PaxDb Q9NFU0
PRIDE Q9NFU0
EnsemblMetazoa FBtr0082197
GeneID 37528
KEGG dme:Dmel_CG6203
UCSC CG6203-RD
CTD 2332
FlyBase FBgn0028734
eggNOG NOG75351
GeneTree ENSGT00390000017033
InParanoid Q9NFU0
KO K15516
OrthoDB EOG7NKKJT
PhylomeDB Q9NFU0
ChiTaRS Fmr1
GenomeRNAi 37528
NextBio 804110
Proteomes UP000000803
Bgee Q9NFU0
ExpressionAtlas Q9NFU0
GO GO:0005737
GO:0005811
GO:0035068
GO:0016442
GO:0042802
GO:0043621
GO:0003723
GO:0007411
GO:0007413
GO:0007409
GO:0007420
GO:0007349
GO:0007623
GO:0050802
GO:0048813
GO:0050976
GO:0031047
GO:0007281
GO:0048134
GO:0007294
GO:0046959
GO:0031507
GO:0008345
GO:0040011
GO:0045475
GO:0007616
GO:0008049
GO:0045448
GO:0051028
GO:0016319
GO:0050774
GO:0045571
GO:0051964
GO:0045886
GO:0017148
GO:0007528
GO:0048812
GO:0008355
GO:0007310
GO:0007279
GO:0042127
GO:0048814
GO:0009794
GO:0090328
GO:0050807
GO:0051823
GO:0006417
GO:0007614
GO:0007288
GO:0007416
GO:0050808
GO:0007601
Gene3D 3.30.1370.10
InterPro IPR008395
IPR004087
IPR004088
IPR022967
Pfam PF00013
SMART SM00322
SM00316
SUPFAM SSF54791
PROSITE PS51641
PS50084

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0045182

translation regulator activity

PMID:11733059[1]

IMP: Inferred from Mutant Phenotype

F

Figure 3, 4, 5, 6, 8. dfxr Overexpression Lines and Nulls Display Postural and Locomotive Defects as Viable Adults; Overexpression and Loss-of-Function of dFXR Gave Rise to Structural and Functional Eye Phenotypes; dfxr Mutants and Overexpression Lines Differentially Affect Synaptic Growth and Structure; Figure 6. dfxr Nulls and Overexpression Lines Differently Affect Evoked and Spontaneous Neurotransmission; Synaptic Phenotypes of dfxr Nulls Are Suppressed by futsch Mutants

complete
CACAO 3434

GO:0002052

positive regulation of neuroblast proliferation

PMID:22513101[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004087

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004088
InterPro:IPR022034

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

GO:0003723

RNA binding

PMID:12446764[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003723

RNA binding

PMID:21068064[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003723

RNA binding

PMID:23666178[5]

IPI: Inferred from Physical Interaction

FB:FBgn0033159

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11733059[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9W596

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

FB:FBgn0003261

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

FB:FBgn0013325

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

FB:FBgn0039016

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

FB:FBgn0064225

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

FB:FBgn0087035

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

UniProtKB:P19109

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

UniProtKB:P46222

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NIU2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VCU9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VUQ5

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12818175[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VF87

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16949822[8]

IPI: Inferred from Physical Interaction

FB:FBgn0004872

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16949822[8]

IPI: Inferred from Physical Interaction

FB:FBgn0283442

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18780789[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VD44

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001318100

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:23874212[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005811

lipid particle

PMID:16979555[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005844

polysome

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001318100

C

Seeded From UniProt

complete

GO:0006417

regulation of translation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0810

P

Seeded From UniProt

complete

GO:0006417

regulation of translation

PMID:11879765[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006417

regulation of translation

PMID:15737929[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007279

pole cell formation

PMID:16888325[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007279

pole cell formation

PMID:16949822[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007281

germ cell development

PMID:15737929[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007281

germ cell development

PMID:19343200[15]

IGI: Inferred from Genetic Interaction

FB:FBgn0262451

P

Seeded From UniProt

complete

GO:0007288

sperm axoneme assembly

PMID:15183715[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007294

germarium-derived oocyte fate determination

PMID:15737929[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007310

oocyte dorsal/ventral axis specification

PMID:15737929[13]

IGI: Inferred from Genetic Interaction

FB:FBgn0004882

P

Seeded From UniProt

complete

GO:0007349

cellularization

PMID:17110444[17]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007349

cellularization

PMID:21068064[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0042134

P

Seeded From UniProt

complete

GO:0007409

axonogenesis

PMID:23666178[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:12086643[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:12818175[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0038320

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:12818175[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:23666178[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007413

axonal fasciculation

PMID:15964283[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007416

synapse assembly

PMID:11879765[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:15964283[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007528

neuromuscular junction development

PMID:18354025[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007601

visual perception

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0844

P

Seeded From UniProt

complete

GO:0007614

short-term memory

PMID:20463240[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007616

long-term memory

PMID:18776892[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007616

long-term memory

PMID:20463240[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007616

long-term memory

PMID:24344294[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007623

circadian rhythm

PMID:12086643[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007623

circadian rhythm

PMID:12086644[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007623

circadian rhythm

PMID:12633995[25]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:12633995[25]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:20463240[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008345

larval locomotory behavior

PMID:15202995[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008355

olfactory learning

PMID:18776892[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008355

olfactory learning

PMID:22080836[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009794

regulation of mitotic cell cycle, embryonic

PMID:21068064[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0042134

P

Seeded From UniProt

complete

GO:0016319

mushroom body development

PMID:15215302[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016442

RISC complex

PMID:12368260[29]

IPI: Inferred from Physical Interaction

FB:FBgn0087035

C

Seeded From UniProt

complete

GO:0016442

RISC complex

PMID:14559182[30]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016442

RISC complex

PMID:15145345[31]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:11733059[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:11733059[1]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:20442204[32]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0017148

negative regulation of translation

PMID:23666178[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031047

gene silencing by RNA

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0943

P

Seeded From UniProt

complete

GO:0031507

heterochromatin assembly

PMID:16888325[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035068

micro-ribonucleoprotein complex

PMID:14559182[30]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0040011

locomotion

PMID:12633995[25]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042127

regulation of cell proliferation

PMID:19306863[33]

IGI: Inferred from Genetic Interaction

FB:FBgn0020224

P

Seeded From UniProt

complete

GO:0042127

regulation of cell proliferation

PMID:19306863[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042802

identical protein binding

PMID:12368261[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NFU0

F

Seeded From UniProt

complete

GO:0043621

protein self-association

PMID:12446764[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0045182

translation regulator activity

PMID:11733059[1]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0045448

mitotic cell cycle, embryonic

PMID:16949822[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045475

locomotor rhythm

PMID:12176363[34]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045475

locomotor rhythm

PMID:15964283[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045475

locomotor rhythm

PMID:20463240[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045571

negative regulation of imaginal disc growth

PMID:23874212[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0015778

P

Seeded From UniProt

complete

GO:0045571

negative regulation of imaginal disc growth

PMID:23874212[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0020279

P

Seeded From UniProt

complete

GO:0045571

negative regulation of imaginal disc growth

PMID:23874212[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0042134

P

Seeded From UniProt

complete

GO:0045886

negative regulation of synaptic growth at neuromuscular junction

PMID:23439121[35]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:22513101[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046959

habituation

PMID:24344294[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048134

germ-line cyst formation

PMID:19306863[33]

IGI: Inferred from Genetic Interaction

FB:FBgn0020224

P

Seeded From UniProt

complete

GO:0048134

germ-line cyst formation

PMID:19306863[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048812

neuron projection morphogenesis

PMID:18354025[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048813

dendrite morphogenesis

PMID:19005053[36]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048814

regulation of dendrite morphogenesis

PMID:14530299[37]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050774

negative regulation of dendrite morphogenesis

PMID:15498496[38]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050802

circadian sleep/wake cycle, sleep

PMID:19228950[39]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050807

regulation of synapse organization

PMID:12818175[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0038320

P

Seeded From UniProt

complete

GO:0050807

regulation of synapse organization

PMID:12818175[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050807

regulation of synapse organization

PMID:15498496[38]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050808

synapse organization

PMID:21669931[40]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050896

response to stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

GO:0050976

detection of mechanical stimulus involved in sensory perception of touch

PMID:23666178[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051028

mRNA transport

PMID:18655836[41]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051823

regulation of synapse structural plasticity

PMID:19738924[42]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051964

negative regulation of synapse assembly

PMID:15621528[43]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051964

negative regulation of synapse assembly

PMID:22080836[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0070142

synaptic vesicle budding

PMID:18280750[44]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0090328

regulation of olfactory learning

PMID:24344294[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097091

synaptic vesicle clustering

PMID:18280750[44]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1900073

regulation of neuromuscular synaptic transmission

PMID:24046358[45]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

NOT

GO:0006935

chemotaxis

PMID:12086644[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

NOT

GO:0007268

synaptic transmission

PMID:12086643[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

NOT

GO:0007614

short-term memory

PMID:24344294[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

NOT

GO:0042331

phototaxis

PMID:12086644[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Zhang, YQ et al. (2001) Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107 591-603 PubMed GONUTS page
  2. 2.0 2.1 Callan, MA et al. (2012) Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. Brain Res. 1462 151-61 PubMed GONUTS page
  3. 3.0 3.1 Siomi, MC et al. (2002) Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties. Mol. Cell. Biol. 22 8438-47 PubMed GONUTS page
  4. 4.0 4.1 4.2 Papoulas, O et al. (2010) dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition. Development 137 4201-9 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Cvetkovska, V et al. (2013) Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting. Nat. Neurosci. 16 677-82 PubMed GONUTS page
  6. 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Ishizuka, A et al. (2002) A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev. 16 2497-508 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Schenck, A et al. (2003) CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Neuron 38 887-98 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Megosh, HB et al. (2006) The role of PIWI and the miRNA machinery in Drosophila germline determination. Curr. Biol. 16 1884-94 PubMed GONUTS page
  9. Kwak, JE et al. (2008) GLD2 poly(A) polymerase is required for long-term memory. Proc. Natl. Acad. Sci. U.S.A. 105 14644-9 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Baumgartner, R et al. (2013) The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster. PLoS Genet. 9 e1003598 PubMed GONUTS page
  11. Cermelli, S et al. (2006) The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr. Biol. 16 1783-95 PubMed GONUTS page
  12. 12.0 12.1 Oostra, BA (2002) Functions of the fragile X protein. Trends Mol Med 8 102-3 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 Costa, A et al. (2005) The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev. Cell 8 331-42 PubMed GONUTS page
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