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PMID:15737929

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Citation

Costa, A, Wang, Y, Dockendorff, TC, Erdjument-Bromage, H, Tempst, P, Schedl, P and Jongens, TA (2005) The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev. Cell 8:331-42

Abstract

Translational regulation of maternal mRNAs in distinct temporal and spatial patterns underlies many key decisions in developing eggs and embryos. In Drosophila, Orb is responsible for mediating the translational activation of mRNAs localized within the developing oocyte. Orb is a germline-specific RNA binding protein and is one of the founding members of the CPEB family of translational regulators. Here we show that Orb associates with the Drosophila Fragile X Mental Retardation (dFMR1) protein as part of a ribonucleoprotein complex that controls the localized translation of mRNAs in developing egg chambers. One of the key orb regulatory targets is orb mRNA, and this autoregulatory activity is critical for ensuring that Orb protein is expressed at high levels in the oocyte. We show that dFMR1 functions as a negative regulator in the orb autoregulatory circuit, downregulating orb mRNA translation.

Links

PubMed Online version:10.1016/j.devcel.2005.01.011

Keywords

Animals; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/embryology; Drosophila melanogaster/metabolism; Female; Fragile X Mental Retardation Protein; Oocytes/growth & development; Oocytes/metabolism; Oogenesis/genetics; Oogenesis/physiology; Protein Binding; Protein Biosynthesis; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q24433

involved_in

GO:0007310: oocyte dorsal/ventral axis specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IHC3

involved_in

GO:0007310: oocyte dorsal/ventral axis specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IHE0

involved_in

GO:0007310: oocyte dorsal/ventral axis specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMZ2

involved_in

GO:0007310: oocyte dorsal/ventral axis specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMZ3

involved_in

GO:0007310: oocyte dorsal/ventral axis specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VCN7

involved_in

GO:0007310: oocyte dorsal/ventral axis specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:FMR1

involved_in

GO:0007294: germarium-derived oocyte fate determination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:FMR1

involved_in

GO:0007310: oocyte dorsal/ventral axis specification

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0004882

P

Seeded From UniProt

complete

DROME:FMR1

involved_in

GO:0006417: regulation of translation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:FMR1

involved_in

GO:0007281: germ cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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