GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12633995
| Citation |
Jin, P and Warren, ST (2003) New insights into fragile X syndrome: from molecules to neurobehaviors. Trends Biochem. Sci. 28:152-8 |
|---|---|
| Abstract |
Fragile X syndrome - a common form of inherited mental retardation - is caused by the loss of the fragile X mental retardation 1 protein (FMRP). FMRP is an RNA-binding protein which forms a messenger ribonucleoprotein (mRNP) complex that associates with translating polyribosomes. It has been proposed that FMRP is involved in synaptic plasticity through the regulation of mRNA transportation and translation. Recent advances in the identification of the mRNA ligands that are bound by FMRP, the RNA sequence and structure required for FMRP-RNA interaction, and the physiological consequences of FMRP deficiency in the brain are important steps towards understanding the molecular pathogenesis of fragile X syndrome, and learning and memory in general. |
| Links |
PubMed Online version:10.1016/S0968-0004(03)00033-1 |
| Keywords |
Animals; Brain/physiopathology; Cell Nucleus/metabolism; Fragile X Mental Retardation Protein; Fragile X Syndrome/genetics; Fragile X Syndrome/metabolism; Fragile X Syndrome/pathology; Fragile X Syndrome/physiopathology; Humans; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neuronal Plasticity; Neurons/metabolism; Nucleic Acid Conformation; Protein Biosynthesis; RNA, Messenger/chemistry; RNA, Messenger/metabolism; RNA-Binding Proteins |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0040011: locomotion |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008049: male courtship behavior |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007623: circadian rhythm |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
See Help:References for how to manage references in GONUTS.
