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DROME:EVE

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) eve
Protein Name(s) Segmentation protein even-skipped
External Links
UniProt P06602
EMBL M14767
X05138
AE013599
U32087
U32088
U32089
U32090
U32091
PIR A26066
RefSeq NP_523670.2
UniGene Dm.18510
PDB 1JGG
PDBsum 1JGG
ProteinModelPortal P06602
SMR P06602
BioGrid 61867
PaxDb P06602
PRIDE P06602
EnsemblMetazoa FBtr0088390
GeneID 36039
KEGG dme:Dmel_CG2328
CTD 36039
FlyBase FBgn0000606
eggNOG NOG298527
GeneTree ENSGT00760000118940
HOGENOM HOG000148791
InParanoid P06602
KO K09320
OMA AFTRDQL
OrthoDB EOG7M98GX
SignaLink P06602
EvolutionaryTrace P06602
GenomeRNAi 36039
NextBio 796502
PRO PR:P06602
Proteomes UP000000803
Bgee P06602
ExpressionAtlas P06602
GO GO:0005634
GO:0000980
GO:0003705
GO:0003700
GO:0007512
GO:0008595
GO:0007350
GO:0045165
GO:0001709
GO:0007417
GO:0007376
GO:0007377
GO:0007507
GO:0003007
GO:0008045
GO:0007517
GO:0009997
GO:0000122
GO:0007366
GO:0045944
GO:0035289
GO:0050770
GO:1901739
GO:0006366
GO:0035290
Gene3D 1.10.10.60
InterPro IPR017970
IPR001356
IPR020479
IPR009057
Pfam PF00046
PRINTS PR00024
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:10885752[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:9362473[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:10644409[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001709

cell fate determination

PMID:12593977[4]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0003007

heart morphogenesis

PMID:19233157[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001356
InterPro:IPR009057
InterPro:IPR020479

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:18271625[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003705

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

PMID:10885752[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003705

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

PMID:12482712[7]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003705

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

PMID:9362473[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:12482712[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:2884106[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0562

P

Seeded From UniProt

complete

GO:0007350

blastoderm segmentation

PMID:11105896[9]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007366

periodic partitioning by pair rule gene

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0562

P

Seeded From UniProt

complete

GO:0007366

periodic partitioning by pair rule gene

PMID:10611687[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007366

periodic partitioning by pair rule gene

PMID:12717812[11]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007366

periodic partitioning by pair rule gene

PMID:15382142[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007376

cephalic furrow formation

PMID:9367430[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007377

germ-band extension

PMID:15030758[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007377

germ-band extension

PMID:15341764[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007417

central nervous system development

PMID:12593977[4]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007507

heart development

PMID:12027431[16]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007512

adult heart development

PMID:19233157[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007517

muscle organ development

PMID:12111720[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:16085495[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008045

motor neuron axon guidance

PMID:24560702[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008595

anterior/posterior axis specification, embryo

PMID:11839291[20]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0009997

negative regulation of cardioblast cell fate specification

PMID:11861486[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035289

posterior head segmentation

PMID:15382142[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0035290

trunk segmentation

PMID:15382142[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

F

Seeded From UniProt

complete

GO:0045165

cell fate commitment

PMID:12027431[16]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:12482712[7]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0050770

regulation of axonogenesis

PMID:13129849[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1901739

regulation of myoblast fusion

PMID:20708593[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Bouchard, M et al. (2000) Combinatorial activity of pair-rule proteins on the Drosophila gooseberry early enhancer. Dev. Biol. 222 135-46 PubMed GONUTS page
  2. 2.0 2.1 Yin, Z et al. (1997) Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development 124 4971-82 PubMed GONUTS page
  3. Shimell, MJ et al. (2000) Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene. Dev. Biol. 218 38-52 PubMed GONUTS page
  4. 4.0 4.1 Skeath, JB & Thor, S (2003) Genetic control of Drosophila nerve cord development. Curr. Opin. Neurobiol. 13 8-15 PubMed GONUTS page
  5. 5.0 5.1 Buechling, T et al. (2009) Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies. Dev. Biol. 328 483-92 PubMed GONUTS page
  6. Li, XY et al. (2008) Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol. 6 e27 PubMed GONUTS page
  7. 7.0 7.1 7.2 Han, Z et al. (2002) Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm. Dev. Biol. 252 225-40 PubMed GONUTS page
  8. Frasch, M et al. (1987) Characterization and localization of the even-skipped protein of Drosophila. EMBO J. 6 749-59 PubMed GONUTS page
  9. Canon, J & Banerjee, U (2000) Runt and Lozenge function in Drosophila development. Semin. Cell Dev. Biol. 11 327-36 PubMed GONUTS page
  10. Davis, GK & Patel, NH (1999) The origin and evolution of segmentation. Trends Cell Biol. 9 M68-72 PubMed GONUTS page
  11. Davis, GK & Patel, NH (2003) Playing by pair-rules? Bioessays 25 425-9 PubMed GONUTS page
  12. 12.0 12.1 12.2 Peel, A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26 1108-16 PubMed GONUTS page
  13. Vincent, A et al. (1997) Integration of the head and trunk segmentation systems controls cephalic furrow formation in Drosophila. Development 124 3747-54 PubMed GONUTS page
  14. Zallen, JA & Wieschaus, E (2004) Patterned gene expression directs bipolar planar polarity in Drosophila. Dev. Cell 6 343-55 PubMed GONUTS page
  15. Baum, B (2004) Animal development: crowd control. Curr. Biol. 14 R716-8 PubMed GONUTS page
  16. 16.0 16.1 Cripps, RM & Olson, EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev. Biol. 246 14-28 PubMed GONUTS page
  17. Dworak, HA & Sink, H (2002) Myoblast fusion in Drosophila. Bioessays 24 591-601 PubMed GONUTS page
  18. Labrador, JP et al. (2005) The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in Drosophila. Curr. Biol. 15 1413-9 PubMed GONUTS page
  19. Zarin, AA et al. (2014) A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection. Neuron 81 1297-311 PubMed GONUTS page
  20. Taylor, MV (2002) Drosophila development: novel signal elicits visceral response. Curr. Biol. 12 R102-4 PubMed GONUTS page
  21. Jagla, T et al. (2002) Cross-repressive interactions of identity genes are essential for proper specification of cardiac and muscular fates in Drosophila. Development 129 1037-47 PubMed GONUTS page
  22. Fujioka, M et al. (2003) Even-skipped, acting as a repressor, regulates axonal projections in Drosophila. Development 130 5385-400 PubMed GONUTS page
  23. Bataillé, L et al. (2010) Downstream of identity genes: muscle-type-specific regulation of the fusion process. Dev. Cell 19 317-28 PubMed GONUTS page