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DROME:EVE

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) eve
Protein Name(s) Segmentation protein even-skipped
External Links
UniProt P06602
EMBL M14767
X05138
AE013599
U32087
U32088
U32089
U32090
U32091
PIR A26066
RefSeq NP_523670.2
UniGene Dm.18510
PDB 1JGG
PDBsum 1JGG
ProteinModelPortal P06602
SMR P06602
BioGrid 61867
PaxDb P06602
PRIDE P06602
EnsemblMetazoa FBtr0088390
GeneID 36039
KEGG dme:Dmel_CG2328
CTD 36039
FlyBase FBgn0000606
eggNOG NOG298527
GeneTree ENSGT00760000118940
HOGENOM HOG000148791
InParanoid P06602
KO K09320
OMA AFTRDQL
OrthoDB EOG7M98GX
SignaLink P06602
EvolutionaryTrace P06602
GenomeRNAi 36039
NextBio 796502
PRO PR:P06602
Proteomes UP000000803
Bgee P06602
ExpressionAtlas P06602
GO GO:0005634
GO:0000980
GO:0003705
GO:0003700
GO:0007512
GO:0008595
GO:0007350
GO:0045165
GO:0001709
GO:0007417
GO:0007376
GO:0007377
GO:0007507
GO:0003007
GO:0008045
GO:0007517
GO:0009997
GO:0000122
GO:0007366
GO:0045944
GO:0035289
GO:0050770
GO:1901739
GO:0006366
GO:0035290
Gene3D 1.10.10.60
InterPro IPR017970
IPR001356
IPR020479
IPR009057
Pfam PF00046
PRINTS PR00024
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0003677

DNA binding

PMID:9380747[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008045

motor neuron axon guidance

PMID:24560702[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901739

regulation of myoblast fusion

PMID:20708593[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003007

heart morphogenesis

PMID:19233157[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007512

adult heart development

PMID:19233157[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:18271625[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008045

motor neuron axon guidance

PMID:16085495[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007377

germ-band extension

PMID:15030758[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050770

regulation of axonogenesis

PMID:13129849[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

PMID:12593977[9]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001709

cell fate determination

PMID:12593977[9]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007366

periodic partitioning by pair rule gene

PMID:12717812[10]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:12482712[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:12482712[11]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12482712[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

PMID:12027431[12]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:12027431[12]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009997

negative regulation of cardioblast cell fate specification

PMID:11861486[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008595

anterior/posterior axis specification, embryo

PMID:11839291[14]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:10885752[15]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:10885752[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:10644409[16]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:9362473[17]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:9362473[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007376

cephalic furrow formation

PMID:9367430[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:2884106[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001356
InterPro:IPR009057
InterPro:IPR020479

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

F

Seeded From UniProt

complete

involved_in

GO:0007377

germ-band extension

PMID:15341764[20]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035289

posterior head segmentation

PMID:15382142[21]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007366

periodic partitioning by pair rule gene

PMID:15382142[21]
PMID:10611687[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0035290

trunk segmentation

PMID:15382142[21]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007517

muscle organ development

PMID:12111720[23]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007350

blastoderm segmentation

PMID:11105896[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007366

periodic partitioning by pair rule gene

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0562

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0371
UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217
UniProtKB-KW:KW-0562

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Hassan, B et al. (1997) Prospero is a panneural transcription factor that modulates homeodomain protein activity. Proc. Natl. Acad. Sci. U.S.A. 94 10991-6 PubMed GONUTS page
  2. ↑ Zarin, AA et al. (2014) A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection. Neuron 81 1297-311 PubMed GONUTS page
  3. ↑ Bataillé, L et al. (2010) Downstream of identity genes: muscle-type-specific regulation of the fusion process. Dev. Cell 19 317-28 PubMed GONUTS page
  4. ↑ 4.0 4.1 Buechling, T et al. (2009) Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies. Dev. Biol. 328 483-92 PubMed GONUTS page
  5. ↑ Li, XY et al. (2008) Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol. 6 e27 PubMed GONUTS page
  6. ↑ Labrador, JP et al. (2005) The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in Drosophila. Curr. Biol. 15 1413-9 PubMed GONUTS page
  7. ↑ Zallen, JA & Wieschaus, E (2004) Patterned gene expression directs bipolar planar polarity in Drosophila. Dev. Cell 6 343-55 PubMed GONUTS page
  8. ↑ Fujioka, M et al. (2003) Even-skipped, acting as a repressor, regulates axonal projections in Drosophila. Development 130 5385-400 PubMed GONUTS page
  9. ↑ 9.0 9.1 Skeath, JB & Thor, S (2003) Genetic control of Drosophila nerve cord development. Curr. Opin. Neurobiol. 13 8-15 PubMed GONUTS page
  10. ↑ Davis, GK & Patel, NH (2003) Playing by pair-rules? Bioessays 25 425-9 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 Han, Z et al. (2002) Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm. Dev. Biol. 252 225-40 PubMed GONUTS page
  12. ↑ 12.0 12.1 Cripps, RM & Olson, EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev. Biol. 246 14-28 PubMed GONUTS page
  13. ↑ Jagla, T et al. (2002) Cross-repressive interactions of identity genes are essential for proper specification of cardiac and muscular fates in Drosophila. Development 129 1037-47 PubMed GONUTS page
  14. ↑ Taylor, MV (2002) Drosophila development: novel signal elicits visceral response. Curr. Biol. 12 R102-4 PubMed GONUTS page
  15. ↑ 15.0 15.1 Bouchard, M et al. (2000) Combinatorial activity of pair-rule proteins on the Drosophila gooseberry early enhancer. Dev. Biol. 222 135-46 PubMed GONUTS page
  16. ↑ Shimell, MJ et al. (2000) Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene. Dev. Biol. 218 38-52 PubMed GONUTS page
  17. ↑ 17.0 17.1 Yin, Z et al. (1997) Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development 124 4971-82 PubMed GONUTS page
  18. ↑ Vincent, A et al. (1997) Integration of the head and trunk segmentation systems controls cephalic furrow formation in Drosophila. Development 124 3747-54 PubMed GONUTS page
  19. ↑ Frasch, M et al. (1987) Characterization and localization of the even-skipped protein of Drosophila. EMBO J. 6 749-59 PubMed GONUTS page
  20. ↑ Baum, B (2004) Animal development: crowd control. Curr. Biol. 14 R716-8 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 Peel, A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26 1108-16 PubMed GONUTS page
  22. ↑ Davis, GK & Patel, NH (1999) The origin and evolution of segmentation. Trends Cell Biol. 9 M68-72 PubMed GONUTS page
  23. ↑ Dworak, HA & Sink, H (2002) Myoblast fusion in Drosophila. Bioessays 24 591-601 PubMed GONUTS page
  24. ↑ Canon, J & Banerjee, U (2000) Runt and Lozenge function in Drosophila development. Semin. Cell Dev. Biol. 11 327-36 PubMed GONUTS page
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