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PMID:15030758
| Citation |
Zallen, JA and Wieschaus, E (2004) Patterned gene expression directs bipolar planar polarity in Drosophila. Dev. Cell 6:343-55 |
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| Abstract |
During convergent extension in Drosophila, polarized cell movements cause the germband to narrow along the dorsal-ventral (D-V) axis and more than double in length along the anterior-posterior (A-P) axis. This tissue remodeling requires the correct patterning of gene expression along the A-P axis, perpendicular to the direction of cell movement. Here, we demonstrate that A-P patterning information results in the polarized localization of cortical proteins in intercalating cells. In particular, cell fate differences conferred by striped expression of the even-skipped and runt pair-rule genes are both necessary and sufficient to orient planar polarity. This polarity consists of an enrichment of nonmuscle myosin II at A-P cell borders and Bazooka/PAR-3 protein at the reciprocal D-V cell borders. Moreover, bazooka mutants are defective for germband extension. These results indicate that spatial patterns of gene expression coordinate planar polarity across a multicellular population through the localized distribution of proteins required for cell movement. |
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| Keywords |
Animals; Animals, Genetically Modified; Antigens, CD; Armadillo Domain Proteins; Body Patterning/genetics; Body Patterning/physiology; Carrier Proteins/metabolism; Cell Adhesion Molecules/metabolism; Cell Movement; Cell Polarity/genetics; Cell Polarity/physiology; DNA-Binding Proteins/metabolism; Drosophila/physiology; Drosophila Proteins/metabolism; Embryo, Nonmammalian; Embryonic Induction; Female; Gene Expression Regulation/physiology; Genes, Insect/genetics; Glycoproteins/physiology; Homeodomain Proteins/metabolism; Immunoglobulins/physiology; Immunohistochemistry/methods; Intracellular Signaling Peptides and Proteins; Male; Mutation; Myosin Type II/metabolism; Nuclear Proteins; Receptors, Cell Surface; Trans-Activators/metabolism; Transcription Factors/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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