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PMID:16085495
Citation |
Labrador, JP, O'keefe, D, Yoshikawa, S, McKinnon, RD, Thomas, JB and Bashaw, GJ (2005) The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in Drosophila. Curr. Biol. 15:1413-9 |
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Abstract |
Homeobox transcription-factor codes control motor-neuron subtype identity and dorsal versus ventral axon guidance in both vertebrate and invertebrate nervous systems; however, the specific axon guidance-receptors that are regulated by these transcription factors to control pathfinding are poorly defined. In Drosophila, the Even-skipped (Eve) transcription factor specifies dorsal motor-axon projection through the regulation of unidentified guidance molecules. The Netrins and their attractive and repulsive receptors DCC and Unc-5, respectively, define important conserved cue and receptor families that control growth-cone guidance. In Drosophila, the Netrins and frazzled (the fly homolog of DCC) contribute to motor-axon guidance. Here, using genetics and single-cell mRNA-expression analysis, we show that expression and requirement of different Netrin receptor combinations correlate with distinct dorsal and ventral motor-axon projections in Drosophila. Mis-expression of eve dorsalizes ventral axons in part through the upregulation of Unc-5, whereas loss of eve function in two dorsally projecting motor neurons results in aberrant axon projections and a failure to express Unc-5. Our results support a functional link between the expression of distinct Netrin receptor combinations and the transcriptional control of dorsal motor-axon guidance. |
Links |
PubMed Online version:10.1016/j.cub.2005.06.058 |
Keywords |
Animals; Drosophila; Drosophila Proteins/metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Growth Cones/metabolism; Growth Cones/physiology; Homeodomain Proteins/metabolism; Immunohistochemistry; Motor Neurons/metabolism; Motor Neurons/physiology; Receptors, Cell Surface/metabolism; Transcription Factors/metabolism |
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Significance
Annotations
Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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References
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