PMID:11105896

Citation	Canon, J and Banerjee, U (2000) Runt and Lozenge function in Drosophila development. Semin. Cell Dev. Biol. 11:327-36
Abstract	Runt and Lozenge (LZ) are members of the Runt domain family of transcriptional regulators and control a large number of developmental processes in Drosophila. Runt is a pair-rule gene, and is part of the network of genes that control pattern formation in the embryo. In the central nervous system, Runt function is necessary for the development of a subset of neurons. Runt is also a key regulator of sex determination, and directly controls Sex-lethal, a master gene that determines sex of the animal and controls dosage compensation. The LZ protein also participates in several key processes. LZ controls pre-patterning and cell-fate choices in the development of the visual system by regulating the expression of several fate-specifying transcription factors, and works in conjunction with general signaling pathways. LZ function is also required in hematopoiesis for the specification of a Drosophila blood cell lineage.
Links	PubMed Online version:10.1006/scdb.2000.0185
Keywords	Animals; Body Patterning/genetics; Body Patterning/physiology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Drosophila Proteins; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Drosophila melanogaster/growth & development; Eye/embryology; Eye/growth & development; Female; Gene Expression Regulation, Developmental; Male; Nuclear Proteins; Sex Determination Processes; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic
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