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DROME:CHDM

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Mi-2
Protein Name(s) Chromodomain-helicase-DNA-binding protein Mi-2 homolog

ATP-dependent helicase Mi-2 dMi-2

External Links
UniProt O97159
EMBL AF119716
AE014296
AY113368
RefSeq NP_001163476.1
NP_649154.2
UniGene Dm.28317
ProteinModelPortal O97159
SMR O97159
BioGrid 65438
DIP DIP-22862N
IntAct O97159
MINT MINT-864813
PaxDb O97159
PRIDE O97159
EnsemblMetazoa FBtr0074919
FBtr0302046
GeneID 40170
KEGG dme:Dmel_CG8103
CTD 40170
FlyBase FBgn0262519
eggNOG COG0553
GeneTree ENSGT00760000119067
InParanoid O97159
KO K11643
OrthoDB EOG7C8GG7
PhylomeDB O97159
ChiTaRS Mi-2
GenomeRNAi 40170
NextBio 817384
PRO PR:O97159
Proteomes UP000000803
Bgee O97159
ExpressionAtlas O97159
GO GO:0005634
GO:0016581
GO:0005700
GO:0005524
GO:0004003
GO:0016887
GO:0003682
GO:0003677
GO:0004386
GO:0031491
GO:0008270
GO:0006200
GO:0048813
GO:0032508
GO:0007517
GO:0071923
GO:0000122
GO:0045892
GO:0042766
GO:0006357
GO:0007283
GO:0006351
Gene3D 3.30.40.10
3.40.50.300
InterPro IPR012957
IPR012958
IPR023780
IPR000953
IPR016197
IPR002464
IPR009462
IPR009463
IPR014001
IPR001650
IPR027417
IPR000330
IPR019786
IPR011011
IPR001965
IPR019787
IPR001841
IPR013083
Pfam PF08074
PF08073
PF00385
PF06461
PF06465
PF00271
PF00628
PF00176
SMART SM00298
SM00487
SM00490
SM00249
SM00184
SUPFAM SSF52540
SSF54160
SSF57903
PROSITE PS50013
PS00690
PS51192
PS51194
PS01359
PS50016

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0043044

ATP-dependent chromatin remodeling

PMID:22912596[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2 shows MI-2's involvement with chromatin structure

complete
CACAO 5897

GO:0051312

chromosome decondensation

PMID:22912596[1]

IMP: Inferred from Mutant Phenotype

P

Fig.5 shows that dMi-2 is required for full decondensation of heat-shock loci.

complete
CACAO 5899

GO:0051276

chromosome organization

PMID:22912596[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2 shows loss of MI-2 function alters chromosome structure.

complete
CACAO 6644

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:19165147[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002464

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012957
InterPro:IPR012958

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003677

DNA binding

PMID:12006495[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003677

DNA binding

PMID:18250149[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003682

chromatin binding

PMID:19165147[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004003

ATP-dependent DNA helicase activity

PMID:10471706[5]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0004386

helicase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

GO:0004386

helicase activity

PMID:10908586[6]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005515

protein binding

PMID:14605208[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VZ27

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15695365[8]

IPI: Inferred from Physical Interaction

FB:FBgn0010762

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19165147[2]

IPI: Inferred from Physical Interaction

FB:FBgn0035357

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19165147[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q0E8J0

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20733004[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q0E8J0

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20733004[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VZ27

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25294943[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q0E8J0

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000330
InterPro:IPR002464
InterPro:IPR012957
InterPro:IPR012958

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012957
InterPro:IPR012958

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:18250149[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:19165147[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:25294944[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005700

polytene chromosome

PMID:11743021[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005700

polytene chromosome

PMID:20733004[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005829

cytosol

PMID:25294944[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012957
InterPro:IPR012958

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:19995906[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007283

spermatogenesis

PMID:23409089[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007517

muscle organ development

PMID:16547170[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008026

ATP-dependent helicase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002464

F

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001841
InterPro:IPR001965
InterPro:IPR012957
InterPro:IPR012958

F

Seeded From UniProt

complete

GO:0008270

zinc ion binding

PMID:21912646[16]

ISM: Inferred from Sequence Model

F

Seeded From UniProt

Missing: with/from

GO:0016581

NuRD complex

PMID:10904264[17]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0016581

NuRD complex

PMID:11743021[12]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016818

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012957
InterPro:IPR012958

F

Seeded From UniProt

complete

GO:0016887

ATPase activity

PMID:12006495[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0016887

ATPase activity

PMID:16223721[18]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0031491

nucleosome binding

PMID:16223721[18]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0031491

nucleosome binding

PMID:18250149[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0032508

DNA duplex unwinding

PMID:10471706[5]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0035327

transcriptionally active chromatin

PMID:18250149[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0042766

nucleosome mobilization

PMID:12006495[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042766

nucleosome mobilization

PMID:16223721[18]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042766

nucleosome mobilization

PMID:18250149[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0043044

ATP-dependent chromatin remodeling

PMID:22912596[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045892

negative regulation of transcription, DNA-templated

PMID:9836641[19]

IGI: Inferred from Genetic Interaction

UniProtKB:P05084

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048813

dendrite morphogenesis

PMID:16547170[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051276

chromosome organization

PMID:22912596[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051312

chromosome decondensation

PMID:22912596[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0070615

nucleosome-dependent ATPase activity

PMID:18250149[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0071923

negative regulation of cohesin localization to chromatin

PMID:22912596[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

contributes_to

GO:0070615

nucleosome-dependent ATPase activity

PMID:19165147[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Fasulo, B et al. (2012) The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. PLoS Genet. 8 e1002878 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Kunert, N et al. (2009) dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression. EMBO J. 28 533-44 PubMed GONUTS page
  3. 3.0 3.1 3.2 Bouazoune, K et al. (2002) The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J. 21 2430-40 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Murawska, M et al. (2008) dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. Mol. Cell. Biol. 28 2745-57 PubMed GONUTS page
  5. 5.0 5.1 Spradling, AC et al. (1999) The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics 153 135-77 PubMed GONUTS page
  6. Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
  7. Giot, L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302 1727-36 PubMed GONUTS page
  8. Kon, C et al. (2005) Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila. Genetics 169 2087-100 PubMed GONUTS page
  9. 9.0 9.1 9.2 Reddy, BA et al. (2010) Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. 30 5234-44 PubMed GONUTS page
  10. Lowe, N et al. (2014) Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Development 141 3994-4005 PubMed GONUTS page
  11. 11.0 11.1 Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
  12. 12.0 12.1 Murawsky, CM et al. (2001) Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. EMBO Rep. 2 1089-94 PubMed GONUTS page
  13. Li, M et al. (2010) Modulation of chromatin boundary activities by nucleosome-remodeling activities in Drosophila melanogaster. Mol. Cell. Biol. 30 1067-76 PubMed GONUTS page
  14. Lindsley, DL et al. (2013) Anent the genomics of spermatogenesis in Drosophila melanogaster. PLoS ONE 8 e55915 PubMed GONUTS page
  15. 15.0 15.1 Parrish, JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev. 20 820-35 PubMed GONUTS page
  16. Ying, M et al. (2011) Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. PLoS ONE 6 e23863 PubMed GONUTS page
  17. Ahringer, J (2000) NuRD and SIN3 histone deacetylase complexes in development. Trends Genet. 16 351-6 PubMed GONUTS page
  18. 18.0 18.1 18.2 Bouazoune, K & Brehm, A (2005) dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation. J. Biol. Chem. 280 41912-20 PubMed GONUTS page
  19. Kehle, J et al. (1998) dMi-2, a hunchback-interacting protein that functions in polycomb repression. Science 282 1897-900 PubMed GONUTS page