DROME:CHDM

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Mi-2
Protein Name(s)	Chromodomain-helicase-DNA-binding protein Mi-2 homolog ATP-dependent helicase Mi-2 dMi-2
External Links
UniProt	O97159
EMBL	AF119716 AE014296 AY113368
RefSeq	NP_001163476.1 NP_649154.2
UniGene	Dm.28317
ProteinModelPortal	O97159
SMR	O97159
BioGrid	65438
DIP	DIP-22862N
IntAct	O97159
MINT	MINT-864813
PaxDb	O97159
PRIDE	O97159
EnsemblMetazoa	FBtr0074919 FBtr0302046
GeneID	40170
KEGG	dme:Dmel_CG8103
CTD	40170
FlyBase	FBgn0262519
eggNOG	COG0553
GeneTree	ENSGT00760000119067
InParanoid	O97159
KO	K11643
OrthoDB	EOG7C8GG7
PhylomeDB	O97159
ChiTaRS	Mi-2
GenomeRNAi	40170
NextBio	817384
PRO	PR:O97159
Proteomes	UP000000803
Bgee	O97159
ExpressionAtlas	O97159
GO	GO:0005634 GO:0016581 GO:0005700 GO:0005524 GO:0004003 GO:0016887 GO:0003682 GO:0003677 GO:0004386 GO:0031491 GO:0008270 GO:0006200 GO:0048813 GO:0032508 GO:0007517 GO:0071923 GO:0000122 GO:0045892 GO:0042766 GO:0006357 GO:0007283 GO:0006351
Gene3D	3.30.40.10 3.40.50.300
InterPro	IPR012957 IPR012958 IPR023780 IPR000953 IPR016197 IPR002464 IPR009462 IPR009463 IPR014001 IPR001650 IPR027417 IPR000330 IPR019786 IPR011011 IPR001965 IPR019787 IPR001841 IPR013083
Pfam	PF08074 PF08073 PF00385 PF06461 PF06465 PF00271 PF00628 PF00176
SMART	SM00298 SM00487 SM00490 SM00249 SM00184
SUPFAM	SSF52540 SSF54160 SSF57903
PROSITE	PS50013 PS00690 PS51192 PS51194 PS01359 PS50016

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0140658	ATP-dependent chromatin remodeler activity	PMID:22912596^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Figure 2 shows MI-2's involvement with chromatin structure GO term changed per Ticket-3833 Dsiegele (talk) 10:46, 29 June 2021 (CDT)	complete CACAO 5897
	GO:0051312	chromosome decondensation	PMID:22912596^[1]	ECO:0000315			P	Fig.5 shows that dMi-2 is required for full decondensation of heat-shock loci.	complete CACAO 5899
	GO:0051276	chromosome organization	PMID:22912596^[1]	ECO:0000315			P	Figure 2 shows loss of MI-2 function alters chromosome structure.	complete CACAO 6644
involved_in	GO:0051312	chromosome decondensation	PMID:22912596^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0140658	ATP-dependent chromatin remodeler activity	PMID:22912596^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt GO term changed per Ticket-3833 Dsiegele (talk) 10:46, 29 June 2021 (CDT)	complete
involved_in	GO:0051276	chromosome organization	PMID:22912596^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9836641^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05084	P	Seeded From UniProt	complete
involved_in	GO:0030261	chromosome condensation	PMID:25501812^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:25294944^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25294944^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:21912646^[5]	ECO:0000255	match to sequence model evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
involved_in	GO:0007283	spermatogenesis	PMID:23409089^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071923	negative regulation of cohesin loading	PMID:22912596^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005700	polytene chromosome	PMID:20733004^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19995906^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
contributes_to	GO:0070615	nucleosome-dependent ATPase activity	PMID:19165147^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19165147^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19165147^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19165147^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18250149^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0070615	nucleosome-dependent ATPase activity	PMID:18250149^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18250149^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042766	nucleosome mobilization	PMID:18250149^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0035327	transcriptionally active chromatin	PMID:18250149^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0031491	nucleosome binding	PMID:18250149^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0031491	nucleosome binding	PMID:16223721^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042766	nucleosome mobilization	PMID:16223721^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:16223721^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12006495^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:12006495^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042766	nucleosome mobilization	PMID:12006495^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005700	polytene chromosome	PMID:11743021^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:10904264^[14]	ECO:0000250	sequence similarity evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
enables	GO:0004386	helicase activity	PMID:10908586^[15]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
part_of	GO:0005634	nucleus	PMID:28522526^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000330	F	Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:11743021^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Fasulo, B et al. (2012) The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. PLoS Genet. 8 e1002878 PubMed GONUTS page
↑ Kehle, J et al. (1998) dMi-2, a hunchback-interacting protein that functions in polycomb repression. Science 282 1897-900 PubMed GONUTS page
↑ Nikalayevich, E & Ohkura, H (2015) The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes. J. Cell. Sci. 128 566-75 PubMed GONUTS page
↑ ^4.0 ^4.1 Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
↑ Ying, M et al. (2011) Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. PLoS ONE 6 e23863 PubMed GONUTS page
↑ Lindsley, DL et al. (2013) Anent the genomics of spermatogenesis in Drosophila melanogaster. PLoS ONE 8 e55915 PubMed GONUTS page
↑ Reddy, BA et al. (2010) Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. 30 5234-44 PubMed GONUTS page
↑ Li, M et al. (2010) Modulation of chromatin boundary activities by nucleosome-remodeling activities in Drosophila melanogaster. Mol. Cell. Biol. 30 1067-76 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Kunert, N et al. (2009) dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression. EMBO J. 28 533-44 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Murawska, M et al. (2008) dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. Mol. Cell. Biol. 28 2745-57 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Bouazoune, K & Brehm, A (2005) dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation. J. Biol. Chem. 280 41912-20 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Bouazoune, K et al. (2002) The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J. 21 2430-40 PubMed GONUTS page
↑ ^13.0 ^13.1 Murawsky, CM et al. (2001) Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. EMBO Rep. 2 1089-94 PubMed GONUTS page
↑ Ahringer, J (2000) NuRD and SIN3 histone deacetylase complexes in development. Trends Genet. 16 351-6 PubMed GONUTS page
↑ Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
↑ Kim, J et al. (2017) Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Science 356 717-721 PubMed GONUTS page

[PMID:22912596-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Fasulo, B et al. (2012) The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. PLoS Genet. 8 e1002878 PubMed GONUTS page

[PMID:9836641-2] Kehle, J et al. (1998) dMi-2, a hunchback-interacting protein that functions in polycomb repression. Science 282 1897-900 PubMed GONUTS page

[PMID:25501812-3] Nikalayevich, E & Ohkura, H (2015) The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes. J. Cell. Sci. 128 566-75 PubMed GONUTS page

[PMID:25294944-4] 4.0 ^4.1 Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page

[PMID:21912646-5] Ying, M et al. (2011) Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. PLoS ONE 6 e23863 PubMed GONUTS page

[PMID:23409089-6] Lindsley, DL et al. (2013) Anent the genomics of spermatogenesis in Drosophila melanogaster. PLoS ONE 8 e55915 PubMed GONUTS page

[PMID:20733004-7] Reddy, BA et al. (2010) Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. 30 5234-44 PubMed GONUTS page

[PMID:19995906-8] Li, M et al. (2010) Modulation of chromatin boundary activities by nucleosome-remodeling activities in Drosophila melanogaster. Mol. Cell. Biol. 30 1067-76 PubMed GONUTS page

[PMID:19165147-9] 9.0 ^9.1 ^9.2 ^9.3 Kunert, N et al. (2009) dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression. EMBO J. 28 533-44 PubMed GONUTS page

[PMID:18250149-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Murawska, M et al. (2008) dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. Mol. Cell. Biol. 28 2745-57 PubMed GONUTS page

[PMID:16223721-11] 11.0 ^11.1 ^11.2 Bouazoune, K & Brehm, A (2005) dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation. J. Biol. Chem. 280 41912-20 PubMed GONUTS page

[PMID:12006495-12] 12.0 ^12.1 ^12.2 Bouazoune, K et al. (2002) The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J. 21 2430-40 PubMed GONUTS page

[PMID:11743021-13] 13.0 ^13.1 Murawsky, CM et al. (2001) Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. EMBO Rep. 2 1089-94 PubMed GONUTS page

[PMID:10904264-14] Ahringer, J (2000) NuRD and SIN3 histone deacetylase complexes in development. Trends Genet. 16 351-6 PubMed GONUTS page

[PMID:10908586-15] Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page

[PMID:28522526-16] Kim, J et al. (2017) Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Science 356 717-721 PubMed GONUTS page

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DROME:CHDM

Contents

Annotations

Notes

References

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