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DROME:CHDM
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | Mi-2 | |
| Protein Name(s) | Chromodomain-helicase-DNA-binding protein Mi-2 homolog
ATP-dependent helicase Mi-2 dMi-2 | |
| External Links | ||
| UniProt | O97159 | |
| EMBL | AF119716 AE014296 AY113368 | |
| RefSeq | NP_001163476.1 NP_649154.2 | |
| UniGene | Dm.28317 | |
| ProteinModelPortal | O97159 | |
| SMR | O97159 | |
| BioGrid | 65438 | |
| DIP | DIP-22862N | |
| IntAct | O97159 | |
| MINT | MINT-864813 | |
| PaxDb | O97159 | |
| PRIDE | O97159 | |
| EnsemblMetazoa | FBtr0074919 FBtr0302046 | |
| GeneID | 40170 | |
| KEGG | dme:Dmel_CG8103 | |
| CTD | 40170 | |
| FlyBase | FBgn0262519 | |
| eggNOG | COG0553 | |
| GeneTree | ENSGT00760000119067 | |
| InParanoid | O97159 | |
| KO | K11643 | |
| OrthoDB | EOG7C8GG7 | |
| PhylomeDB | O97159 | |
| ChiTaRS | Mi-2 | |
| GenomeRNAi | 40170 | |
| NextBio | 817384 | |
| PRO | PR:O97159 | |
| Proteomes | UP000000803 | |
| Bgee | O97159 | |
| ExpressionAtlas | O97159 | |
| GO | GO:0005634 GO:0016581 GO:0005700 GO:0005524 GO:0004003 GO:0016887 GO:0003682 GO:0003677 GO:0004386 GO:0031491 GO:0008270 GO:0006200 GO:0048813 GO:0032508 GO:0007517 GO:0071923 GO:0000122 GO:0045892 GO:0042766 GO:0006357 GO:0007283 GO:0006351 | |
| Gene3D | 3.30.40.10 3.40.50.300 | |
| InterPro | IPR012957 IPR012958 IPR023780 IPR000953 IPR016197 IPR002464 IPR009462 IPR009463 IPR014001 IPR001650 IPR027417 IPR000330 IPR019786 IPR011011 IPR001965 IPR019787 IPR001841 IPR013083 | |
| Pfam | PF08074 PF08073 PF00385 PF06461 PF06465 PF00271 PF00628 PF00176 | |
| SMART | SM00298 SM00487 SM00490 SM00249 SM00184 | |
| SUPFAM | SSF52540 SSF54160 SSF57903 | |
| PROSITE | PS50013 PS00690 PS51192 PS51194 PS01359 PS50016 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0140658 |
ATP-dependent chromatin remodeler activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Figure 2 shows MI-2's involvement with chromatin structure GO term changed per Ticket-3833 Dsiegele (talk) 10:46, 29 June 2021 (CDT) |
complete | ||||
| GO:0051312 |
chromosome decondensation |
ECO:0000315 |
P |
Fig.5 shows that dMi-2 is required for full decondensation of heat-shock loci. |
complete | |||||
| GO:0051276 |
chromosome organization |
ECO:0000315 |
P |
Figure 2 shows loss of MI-2 function alters chromosome structure. |
complete | |||||
|
involved_in |
GO:0051312 |
chromosome decondensation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0140658 |
ATP-dependent chromatin remodeler activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt GO term changed per Ticket-3833 Dsiegele (talk) 10:46, 29 June 2021 (CDT) |
complete | |||
|
involved_in |
GO:0051276 |
chromosome organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030261 |
chromosome condensation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071923 |
negative regulation of cohesin loading |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005700 |
polytene chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0070615 |
nucleosome-dependent ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070615 |
nucleosome-dependent ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042766 |
nucleosome mobilization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035327 |
transcriptionally active chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031491 |
nucleosome binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031491 |
nucleosome binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042766 |
nucleosome mobilization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016887 |
ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016887 |
ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042766 |
nucleosome mobilization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005700 |
polytene chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016581 |
NuRD complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
Missing: with/from | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016581 |
NuRD complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Fasulo, B et al. (2012) The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. PLoS Genet. 8 e1002878 PubMed GONUTS page
- ↑ Kehle, J et al. (1998) dMi-2, a hunchback-interacting protein that functions in polycomb repression. Science 282 1897-900 PubMed GONUTS page
- ↑ Nikalayevich, E & Ohkura, H (2015) The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes. J. Cell. Sci. 128 566-75 PubMed GONUTS page
- ↑ 4.0 4.1 Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
- ↑ Ying, M et al. (2011) Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. PLoS ONE 6 e23863 PubMed GONUTS page
- ↑ Lindsley, DL et al. (2013) Anent the genomics of spermatogenesis in Drosophila melanogaster. PLoS ONE 8 e55915 PubMed GONUTS page
- ↑ Reddy, BA et al. (2010) Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol. Cell. Biol. 30 5234-44 PubMed GONUTS page
- ↑ Li, M et al. (2010) Modulation of chromatin boundary activities by nucleosome-remodeling activities in Drosophila melanogaster. Mol. Cell. Biol. 30 1067-76 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Kunert, N et al. (2009) dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression. EMBO J. 28 533-44 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Murawska, M et al. (2008) dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. Mol. Cell. Biol. 28 2745-57 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Bouazoune, K & Brehm, A (2005) dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation. J. Biol. Chem. 280 41912-20 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Bouazoune, K et al. (2002) The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J. 21 2430-40 PubMed GONUTS page
- ↑ 13.0 13.1 Murawsky, CM et al. (2001) Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. EMBO Rep. 2 1089-94 PubMed GONUTS page
- ↑ Ahringer, J (2000) NuRD and SIN3 histone deacetylase complexes in development. Trends Genet. 16 351-6 PubMed GONUTS page
- ↑ Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
- ↑ Kim, J et al. (2017) Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Science 356 717-721 PubMed GONUTS page
a
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- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- Neoptera
- GO:0070615 ! nucleosome-dependent ATPase activity
- GO:0031491 ! nucleosome binding
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
- GO:0016581 ! NuRD complex
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