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PMID:9836641
| Citation |
Kehle, J, Beuchle, D, Treuheit, S, Christen, B, Kennison, JA, Bienz, M and Müller, J (1998) dMi-2, a hunchback-interacting protein that functions in polycomb repression. Science 282:1897-900 |
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| Abstract |
Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically required for the repression of HOX genes. Genetic analyses show that dMi-2 participates in both Hunchback and Polycomb repression in vivo. Hence, recruitment of dMi-2 may serve as a link between repression of HOX genes by Hunchback and Polycomb proteins. |
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| Keywords |
Adenosine Triphosphatases; Animals; Autoantigens/chemistry; Autoantigens/genetics; Autoantigens/metabolism; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Drosophila/embryology; Drosophila/genetics; Drosophila Proteins; Embryo, Nonmammalian/metabolism; Gene Dosage; Gene Expression Regulation, Developmental; Genes, Homeobox; Genes, Insect; Genetic Complementation Test; Germ Cells/metabolism; Heterozygote; Homeodomain Proteins/genetics; In Situ Hybridization; Insect Proteins/genetics; Insect Proteins/metabolism; Mutation; Recombinant Fusion Proteins; Transcription Factors/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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