DANRE:Q90XD1

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	No Information Provided.
Protein Name(s)	HMG-box transcription factor Sox10 (ECO:0000313 with EMBL:AAK84872.1) Sox10 protein (ECO:0000313 with EMBL:AAI63868.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000100237)
External Links
UniProt	Q90XD1
EMBL	CU695115 BC163868 BC163883 AF402677
RefSeq	NP_571950.1
UniGene	Dr.83682
SMR	Q90XD1
Ensembl	ENSDART00000112979
GeneID	140616
KEGG	dre:140616
CTD	6663
ZFIN	ZDB-GENE-011207-1
GeneTree	ENSGT00760000118988
HOGENOM	HOG000108876
HOVERGEN	HBG002061
KO	K09270
OMA	MANMEPF
OrthoDB	EOG7Q2N5K
PhylomeDB	Q90XD1
NextBio	20797027
PRO	PR:Q90XD1
Proteomes	UP000000437
GO	GO:0048484 GO:0010001 GO:0048839 GO:0030318 GO:0050768 GO:0014032 GO:0001755 GO:0048709 GO:0071600 GO:0048840 GO:0010628 GO:0014044 GO:0014037 GO:0048752
Gene3D	1.10.30.10
InterPro	IPR009071 IPR022151
Pfam	PF00505 PF12444
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0021772	olfactory bulb development	PMID:23539289^[1]	ECO:0000315			P	Fig 5 for Sox10	complete CACAO 7308
involved_in	GO:0021772	olfactory bulb development	PMID:23539289^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904888	cranial skeletal system development	PMID:27418670^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-170208-2 ZFIN:ZDB-MRPHLNO-170208-3	P	Seeded From UniProt	complete
involved_in	GO:1904888	cranial skeletal system development	PMID:27418670^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051220-4 ZFIN:ZDB-MRPHLNO-170208-2	P	Seeded From UniProt	complete
involved_in	GO:0071600	otic vesicle morphogenesis	PMID:9007247^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050931	pigment cell differentiation	PMID:9007256^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1190	P	Seeded From UniProt	complete
involved_in	GO:0050931	pigment cell differentiation	PMID:9007256^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1189	P	Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	PMID:15677337^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-291	P	Seeded From UniProt	complete
involved_in	GO:0048840	otolith development	PMID:19132125^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1565	P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:19132125^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090422-9	P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:19132125^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1565 ZFIN:ZDB-MRPHLNO-090422-7 ZFIN:ZDB-MRPHLNO-090422-8	P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:19132125^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1565 ZFIN:ZDB-MRPHLNO-070130-7 ZFIN:ZDB-MRPHLNO-090422-9	P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:19132125^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1565 ZFIN:ZDB-MRPHLNO-070130-7 ZFIN:ZDB-MRPHLNO-090422-7 ZFIN:ZDB-MRPHLNO-090422-8	P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:19132125^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1565	P	Seeded From UniProt	complete
involved_in	GO:0048752	semicircular canal morphogenesis	PMID:19132125^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1565	P	Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	PMID:17065232^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070131-8	P	Seeded From UniProt	complete
involved_in	GO:0048484	enteric nervous system development	PMID:15817223^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-136	P	Seeded From UniProt	complete
involved_in	GO:0048484	enteric nervous system development	PMID:15817223^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1190	P	Seeded From UniProt	complete
involved_in	GO:0048066	developmental pigmentation	PMID:9007256^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1190	P	Seeded From UniProt	complete
involved_in	GO:0048066	developmental pigmentation	PMID:9007256^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1189	P	Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	PMID:27418670^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-170208-3	P	Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	PMID:27418670^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051220-4	P	Seeded From UniProt	complete
involved_in	GO:0030318	melanocyte differentiation	PMID:22562198^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-011207-1 ZFIN:ZDB-GENO-121004-5	P	Seeded From UniProt	complete
involved_in	GO:0022011	myelination in peripheral nervous system	PMID:27418670^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-170208-2 ZFIN:ZDB-MRPHLNO-170208-3	P	Seeded From UniProt	complete
involved_in	GO:0022011	myelination in peripheral nervous system	PMID:27418670^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051220-4 ZFIN:ZDB-MRPHLNO-170208-2 ZFIN:ZDB-MRPHLNO-170208-3	P	Seeded From UniProt	complete
involved_in	GO:0014044	Schwann cell development	PMID:19955371^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-110803-1	P	Seeded From UniProt	complete
involved_in	GO:0014044	Schwann cell development	PMID:18176560^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080430-1	P	Seeded From UniProt	complete
involved_in	GO:0014044	Schwann cell development	PMID:18176560^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080402-2	P	Seeded From UniProt	complete
involved_in	GO:0014037	Schwann cell differentiation	PMID:17065232^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070131-8	P	Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	PMID:11684650^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-136	P	Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	PMID:10631172^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1565	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:19527705^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-990910-11	P	Seeded From UniProt	complete
involved_in	GO:0010001	glial cell differentiation	PMID:19570850^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090825-1 ZFIN:ZDB-MRPHLNO-090825-3	P	Seeded From UniProt	complete
involved_in	GO:0010001	glial cell differentiation	PMID:19570850^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-090826-2 ZFIN:ZDB-MRPHLNO-090825-1	P	Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	PMID:15817223^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-136	P	Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	PMID:15817223^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1190	P	Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98358 MGI:MGI:98370 MGI:MGI:98371 PANTHER:PTN001615967 UniProtKB:P57074	P	Seeded From UniProt	complete
involved_in	GO:0048484	enteric nervous system development	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000741647 ZFIN:ZDB-GENE-011207-1	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98358 MGI:MGI:98370 MGI:MGI:98371 PANTHER:PTN000741645 RGD:620474 UniProtKB:O18896 UniProtKB:P48436 UniProtKB:P57073	P	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98371 PANTHER:PTN001615967	P	Seeded From UniProt	complete
involved_in	GO:0002009	morphogenesis of an epithelium	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000741645 UniProtKB:P48434	P	Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000741647 ZFIN:ZDB-GENE-011207-1	P	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98371 PANTHER:PTN000741645	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000400811	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000400811	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Saxena, A et al. (2013) Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish. Elife 2 e00336 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Asad, Z et al. (2016) Rescue of neural crest-derived phenotypes in a zebrafish CHARGE model by Sox10 downregulation. Hum. Mol. Genet. 25 3539-3554 PubMed GONUTS page
↑ Malicki, J et al. (1996) Mutations affecting development of the zebrafish ear. Development 123 275-83 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Kelsh, RN et al. (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development 123 369-89 PubMed GONUTS page
↑ López-Schier, H & Hudspeth, AJ (2005) Supernumerary neuromasts in the posterior lateral line of zebrafish lacking peripheral glia. Proc. Natl. Acad. Sci. U.S.A. 102 1496-501 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Dutton, K et al. () A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle. Dis Model Mech 2 68-83 PubMed GONUTS page
↑ ^7.0 ^7.1 Carney, TJ et al. (2006) A direct role for Sox10 in specification of neural crest-derived sensory neurons. Development 133 4619-30 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Elworthy, S et al. (2005) Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Mech. Dev. 122 659-69 PubMed GONUTS page
↑ An, M & Henion, PD (2012) The zebrafish sf3b1b460 mutant reveals differential requirements for the sf3b1 pre-mRNA processing gene during neural crest development. Int. J. Dev. Biol. 56 223-37 PubMed GONUTS page
↑ Kucenas, S et al. (2009) A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord. J. Neurosci. 29 15187-94 PubMed GONUTS page
↑ ^11.0 ^11.1 Kucenas, S et al. (2008) CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nat. Neurosci. 11 143-51 PubMed GONUTS page
↑ Dutton, KA et al. (2001) Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates. Development 128 4113-25 PubMed GONUTS page
↑ Kelsh, RN & Eisen, JS (2000) The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives. Development 127 515-25 PubMed GONUTS page
↑ Curran, K et al. (2009) Foxd3 controls melanophore specification in the zebrafish neural crest by regulation of Mitf. Dev. Biol. 332 408-17 PubMed GONUTS page
↑ ^15.0 ^15.1 Drerup, CM et al. (2009) Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development 136 2623-32 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23539289-1] 1.0 ^1.1 Saxena, A et al. (2013) Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish. Elife 2 e00336 PubMed GONUTS page

[PMID:27418670-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Asad, Z et al. (2016) Rescue of neural crest-derived phenotypes in a zebrafish CHARGE model by Sox10 downregulation. Hum. Mol. Genet. 25 3539-3554 PubMed GONUTS page

[PMID:9007247-3] Malicki, J et al. (1996) Mutations affecting development of the zebrafish ear. Development 123 275-83 PubMed GONUTS page

[PMID:9007256-4] 4.0 ^4.1 ^4.2 ^4.3 Kelsh, RN et al. (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development 123 369-89 PubMed GONUTS page

[PMID:15677337-5] López-Schier, H & Hudspeth, AJ (2005) Supernumerary neuromasts in the posterior lateral line of zebrafish lacking peripheral glia. Proc. Natl. Acad. Sci. U.S.A. 102 1496-501 PubMed GONUTS page

[PMID:19132125-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Dutton, K et al. () A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle. Dis Model Mech 2 68-83 PubMed GONUTS page

[PMID:17065232-7] 7.0 ^7.1 Carney, TJ et al. (2006) A direct role for Sox10 in specification of neural crest-derived sensory neurons. Development 133 4619-30 PubMed GONUTS page

[PMID:15817223-8] 8.0 ^8.1 ^8.2 ^8.3 Elworthy, S et al. (2005) Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Mech. Dev. 122 659-69 PubMed GONUTS page

[PMID:22562198-9] An, M & Henion, PD (2012) The zebrafish sf3b1b460 mutant reveals differential requirements for the sf3b1 pre-mRNA processing gene during neural crest development. Int. J. Dev. Biol. 56 223-37 PubMed GONUTS page

[PMID:19955371-10] Kucenas, S et al. (2009) A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord. J. Neurosci. 29 15187-94 PubMed GONUTS page

[PMID:18176560-11] 11.0 ^11.1 Kucenas, S et al. (2008) CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nat. Neurosci. 11 143-51 PubMed GONUTS page

[PMID:11684650-12] Dutton, KA et al. (2001) Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates. Development 128 4113-25 PubMed GONUTS page

[PMID:10631172-13] Kelsh, RN & Eisen, JS (2000) The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives. Development 127 515-25 PubMed GONUTS page

[PMID:19527705-14] Curran, K et al. (2009) Foxd3 controls melanophore specification in the zebrafish neural crest by regulation of Mitf. Dev. Biol. 332 408-17 PubMed GONUTS page

[PMID:19570850-15] 15.0 ^15.1 Drerup, CM et al. (2009) Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development 136 2623-32 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:Q90XD1

Contents

Annotations

Notes

References

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