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PMID:19955371

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Citation

Kucenas, S, Wang, WD, Knapik, EW and Appel, B (2009) A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord. J. Neurosci. 29:15187-94

Abstract

Nerve roots have specialized transition zones that permit axon extension but limit cell movement between the CNS and PNS. Boundary cap cells prevent motor neuron soma from following their axons into the periphery, thereby contributing to a selective barrier. Transition zones also restrict movement of glial cells. Consequently, axons that cross the CNS-PNS interface are insulated by central and peripheral myelin. The mechanisms that prevent the migratory progenitors of oligodendrocytes and Schwann cells, the myelinating cells of the CNS and PNS, respectively, from crossing transition zones are not known. Here, we show that interactions between myelinating glial cells prevent their movements across the interface. Using in vivo time-lapse imaging in zebrafish we found that, in the absence of Schwann cells, oligodendrocyte progenitors cross ventral root transition zones and myelinate motor axons. These studies reveal that distinct mechanisms regulate the movement of axons, neurons, and glial cells across the CNS-PNS interface.

Links

PubMed PMC2837368 Online version:10.1523/JNEUROSCI.4193-09.2009

Keywords

Age Factors; Animals; Animals, Genetically Modified; Axons/physiology; Axons/ultrastructure; Cell Movement/genetics; Cell Movement/physiology; Embryonic Stem Cells/physiology; Green Fluorescent Proteins/genetics; Larva; Microscopy, Confocal; Microscopy, Electron/methods; Motor Neurons/cytology; Myelin Basic Proteins/metabolism; Oligodendroglia/physiology; Oligodendroglia/ultrastructure; Spinal Cord/cytology; Spinal Nerves/physiology; Zebrafish; Zebrafish Proteins/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A2R8QRQ5

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:A0A2R8RSI4

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:A0PJQ1

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-110803-1

P

Seeded From UniProt

complete

DANRE:F1QUT4

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:F1QUT5

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:F1R5S7

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:O73782

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:Q502Q4

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:Q6DBW6

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-110803-1

P

Seeded From UniProt

complete

DANRE:Q6NYI3

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:Q6P975

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:Q6YA67

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:Q8UVE5

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:Q8UVE6

involved_in

GO:0014032: neural crest cell development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-110803-2

P

Seeded From UniProt

complete

DANRE:Q90XD1

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-110803-1

P

Seeded From UniProt

complete


See also

References

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