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PMID:17065232
| Citation |
Carney, TJ, Dutton, KA, Greenhill, E, Delfino-Machín, M, Dufourcq, P, Blader, P and Kelsh, RN (2006) A direct role for Sox10 in specification of neural crest-derived sensory neurons. Development 133:4619-30 |
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| Abstract |
sox10 is necessary for development of neural and pigment cell derivatives of the neural crest (NC). However, whereas a direct role for Sox10 activity has been established in pigment and glial lineages, this is more controversial in NC-derived sensory neurons of the dorsal root ganglia (DRGs). We proposed that sox10 functioned in specification of sensory neurons, whereas others suggested that sensory neuronal defects were merely secondary to absence of glia. Here we provide evidence that in zebrafish, early DRG sensory neuron survival is independent of differentiated glia. Critically, we demonstrate that Sox10 is expressed transiently in the sensory neuron lineage, and specifies sensory neuron precursors by regulating the proneural gene neurogenin1. Consistent with this, we have isolated a novel sox10 mutant that lacks glia and yet displays a neurogenic DRG phenotype. In conjunction with previous findings, these data establish the generality of our model of Sox10 function in NC fate specification. |
| Links |
PubMed Online version:10.1242/dev.02668 |
| Keywords |
Alleles; Animals; Animals, Genetically Modified; Base Sequence; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/physiology; Carrier Proteins/genetics; Carrier Proteins/physiology; Cell Survival; DNA/genetics; Ganglia, Spinal/cytology; Ganglia, Spinal/embryology; Gene Expression Regulation, Developmental; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; High Mobility Group Proteins/genetics; High Mobility Group Proteins/physiology; Models, Neurological; Mutation; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Neural Crest/cytology; Neural Crest/embryology; Neurons, Afferent/cytology; Phenotype; Promoter Regions, Genetic; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; SOXE Transcription Factors; Stem Cells/cytology; Zebrafish/embryology; Zebrafish/genetics; Zebrafish Proteins/genetics; Zebrafish Proteins/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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