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PMID:9007247

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Citation

Malicki, J, Schier, AF, Solnica-Krezel, L, Stemple, DL, Neuhauss, SC, Stainier, DY, Abdelilah, S, Rangini, Z, Zwartkruis, F and Driever, W (1996) Mutations affecting development of the zebrafish ear. Development 123:275-83

Abstract

In a large scale screen for genetic defects in zebrafish embryogenesis we identified mutations affecting several aspects of ear development, including: specification of the otic placode, growth of the otic vesicle (otocyst), otolith formation, morphogenesis of the semicircular canals and differentiation of the otic capsule. Here we report initial phenotypic and genetic characterization of 20 of these mutations defining 13 independent loci. Embryos mutant at the quadro locus display abnormal specification of the otic placode. As revealed by dlx-3 expression, the otic field in the mutant embryos is smaller or split into two fields. At later stages of development the ear of quadro mutants is frequently divided into two smaller, incomplete units. Four loci affect ear shape shortly after formation of the otic vesicle. All of them also display abnormal brain morphology. Mutations in five loci result in the absence of otolith formation; two of these also produce changes of ear morphology. Two loci, little richard and golas, affect morphology of the otic vesicle shortly before formation of the semicircular canals. In both cases the morphogenesis of the semicircular canals is disrupted. Finally, the antytalent locus is involved in late expansion of the ear structure. Analysis of mutations presented here will strengthen our understanding of vertebrate ear morphogenesis and provide novel entry points to its genetic analysis.

Links

PubMed

Keywords

Animals; Ear/embryology; Embryonic Development; Gene Expression Regulation, Developmental; Male; Mutagenesis; Otolithic Membrane/embryology; Phenotype; Zebrafish/anatomy & histology; Zebrafish/embryology; Zebrafish/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0PJQ1

involved_in

GO:0071600: otic vesicle morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q6DBW6

involved_in

GO:0071600: otic vesicle morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q6DG75

involved_in

GO:0043049: otic placode formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q7T2N8

involved_in

GO:0043049: otic placode formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q7ZU25

involved_in

GO:0071599: otic vesicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q7ZZK6

involved_in

GO:0071599: otic vesicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q804B2

involved_in

GO:0043049: otic placode formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:SPT6H

involved_in

GO:0071599: otic vesicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q9DGL6

involved_in

GO:0071599: otic vesicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:MIB1

involved_in

GO:0071599: otic vesicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:Q90XD1

involved_in

GO:0071600: otic vesicle morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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