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Category:Team Lost in translation

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableHUMAN:COX5AVawaiyaki, Team Lost in translation2016-04-19 05:57:13 CDTGO:0010507 negative regulation of autophagy (P)PMID:20660724ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3b displays how the knock down of Cox5a resulted in the induction of autophagy in cells transfected with siRNAs against Cox5a or controls. The autophagy levels were then tested with antibodies against p62m Atg5 (Atg12-Atg5 complex) and LC3.

challenge
unacceptableHUMAN:COX5AVawaiyaki, Team Lost in translation2016-04-19 05:39:43 CDTGO:2000378 negative regulation of reactive oxygen species metabolic process (P)PMID:20660724ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3a displays how the knock down of Cox5a led to accumulation of reactive oxygen species in H4 cells.

challenge
unacceptableSCHPO:LEM2Mkkayumbi, Team Lost in translation2016-04-19 02:06:53 CDTGO:0010629 negative regulation of gene expression (P)PMID:26744419ECO:0000315 mutant phenotype evidence used in manual assertion

Lem2 is deleted and there is more transcription

challenge
unacceptableSCHPO:LEM2Mkkayumbi, Team Lost in translation2016-04-19 02:02:06 CDTGO:0010629 negative regulation of gene expression (P)ECO:0000315 mutant phenotype evidence used in manual assertion

Lem2 negative regulation of gene expression

challenge
unacceptableECOLI:PTGCBVawaiyaki, Team Lost in translation2016-04-19 01:49:41 CDTGO:0019664 mixed acid fermentation (P)PMID:11133439ECO:0000314 direct assay evidence used in manual assertion

Table 5 displays that in all cases the inactivation of ptsG gene resulted in a shift in fermentation toward succinate.

challenge
unacceptableMOUSE:FOXA2Vawaiyaki, Team Lost in translation2016-04-11 10:50:23 CDTGO:0060303 regulation of nucleosome density (P)PMID:27058788ECO:0000315 mutant phenotype evidence used in manual assertion

In figure 5 b, there is decreased low Mnase-seq signal when FoxA2 is deleted. This effect is significant for the FoxA2 strong promoters only whereas it is marginal for the FoxA2 weak promoters.

challenge

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Pages in category "Team Lost in translation"

The following 2 pages are in this category, out of 2 total.


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