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User:Vawaiyaki

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CACAO Spring 2016

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableMOUSE:FOXA22016-04-11 10:50:23 CDTGO:0060303 regulation of nucleosome density (P)PMID:27058788ECO:0000315 mutant phenotype evidence used in manual assertion

In figure 5 b, there is decreased low Mnase-seq signal when FoxA2 is deleted. This effect is significant for the FoxA2 strong promoters only whereas it is marginal for the FoxA2 weak promoters.

challenge
unacceptableECOLI:PTGCB2016-04-19 01:49:41 CDTGO:0019664 mixed acid fermentation (P)PMID:11133439ECO:0000314 direct assay evidence used in manual assertion

Table 5 displays that in all cases the inactivation of ptsG gene resulted in a shift in fermentation toward succinate.

challenge
unacceptableHUMAN:COX5A2016-04-19 05:39:43 CDTGO:2000378 negative regulation of reactive oxygen species metabolic process (P)PMID:20660724ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3a displays how the knock down of Cox5a led to accumulation of reactive oxygen species in H4 cells.

challenge
unacceptableHUMAN:COX5A2016-04-19 05:57:13 CDTGO:0010507 negative regulation of autophagy (P)PMID:20660724ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3b displays how the knock down of Cox5a resulted in the induction of autophagy in cells transfected with siRNAs against Cox5a or controls. The autophagy levels were then tested with antibodies against p62m Atg5 (Atg12-Atg5 complex) and LC3.

challenge

acceptable:0
unacceptable:4
requires_changes:0
flagged:0

Annotations challenged by Vawaiyaki

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