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ECOLI:PTGCB

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) ptsG (synonyms: glcA, umg)
Protein Name(s) PTS system glucose-specific EIICB component

EIICB-Glc EII-Glc Glucose permease IIC component PTS system glucose-specific EIIC component Glucose-specific phosphotransferase enzyme IIB component PTS system glucose-specific EIIB component

External Links
UniProt P69786
EMBL J02618
U00096
AP009048
PIR A25336
RefSeq NP_415619.1
YP_489369.1
PDB 1IBA
1O2F
3BP3
3BP8
PDBsum 1IBA
1O2F
3BP3
3BP8
ProteinModelPortal P69786
SMR P69786
DIP DIP-29833N
IntAct P69786
STRING 511145.b1101
MoonProt P69786
TCDB 4.A.1.1.1
PaxDb P69786
PRIDE P69786
EnsemblBacteria AAC74185
BAA35908
GeneID 12931946
945651
KEGG ecj:Y75_p1071
eco:b1101
PATRIC 32117443
EchoBASE EB0780
EcoGene EG10787
eggNOG COG1263
HOGENOM HOG000250993
KO K02778
K02779
OMA MQIGEFT
OrthoDB EOG6FFS9V
PhylomeDB P69786
BioCyc EcoCyc:PTSG-MONOMER
ECOL316407:JW1087-MONOMER
MetaCyc:PTSG-MONOMER
EvolutionaryTrace P69786
PRO PR:P69786
Proteomes UP000000318
UP000000625
Genevestigator P69786
GO GO:0005829
GO:0005887
GO:0005355
GO:0016301
GO:0008982
GO:0090564
GO:0034219
GO:0061490
GO:0015758
GO:0009401
Gene3D 3.30.1360.60
InterPro IPR018113
IPR003352
IPR013013
IPR001996
IPR011299
IPR004719
Pfam PF00367
PF02378
SUPFAM SSF55604
TIGRFAMs TIGR00826
TIGR00852
TIGR02002
PROSITE PS51098
PS01035
PS51103

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1904659

glucose transmembrane transport

PMID:22234496[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0090564

protein-phosphocysteine-glucose phosphotransferase system transporter activity

PMID:8505292[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0090564

protein-phosphocysteine-glucose phosphotransferase system transporter activity

PMID:3129430[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009401

phosphoenolpyruvate-dependent sugar phosphotransferase system

PMID:8505292[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0016021

integral to membrane

PMID:3129430[3]

ECO:0000255

C

Fig 1b - shows hydropathy profile of IIGLC

Missing: with/from
CACAO 2066

part_of

GO:0005887

integral component of plasma membrane

PMID:3047116[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0015758

glucose transport

PMID:22234496[1]

ECO:0000315

P

Figure 1 shows transporting glucose into the cell and out of the extracellular space

complete
CACAO 5780

part_of

GO:0005886

plasma membrane

PMID:17309111[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15919996[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15576795[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005355

glucose transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011299

F

Seeded From UniProt

complete

GO:0019664

mixed acid fermentation

PMID:11133439[8]

ECO:0000314

P

Table 5 displays that in all cases the inactivation of ptsG gene resulted in a shift in fermentation toward succinate.

complete
CACAO 11777

enables

GO:0008982

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001996
InterPro:IPR003352
InterPro:IPR004719
InterPro:IPR018113
InterPro:IPR036878

F

Seeded From UniProt

complete

involved_in

GO:0009401

phosphoenolpyruvate-dependent sugar phosphotransferase system

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001996
InterPro:IPR003352
InterPro:IPR004719
InterPro:IPR036878

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003352

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004719
InterPro:IPR011299

C

Seeded From UniProt

complete

involved_in

GO:1904659

glucose transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011299

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0009401

phosphoenolpyruvate-dependent sugar phosphotransferase system

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0598

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0997
UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0037

C

Seeded From UniProt

complete

involved_in

GO:0008643

carbohydrate transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0762

P

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Valdivia-González, M et al. (2012) Effect of tellurite-mediated oxidative stress on the Escherichia coli glycolytic pathway. Biometals 25 451-8 PubMed GONUTS page
  2. 2.0 2.1 Meins, M et al. (1993) Cysteine phosphorylation of the glucose transporter of Escherichia coli. J. Biol. Chem. 268 11604-9 PubMed GONUTS page
  3. 3.0 3.1 Nuoffer, C et al. (1988) Glucose permease of Escherichia coli. The effect of cysteine to serine mutations on the function, stability, and regulation of transport and phosphorylation. J. Biol. Chem. 263 6647-55 PubMed GONUTS page
  4. Meins, M et al. (1988) Glucose permease of Escherichia coli. Purification of the IIGlc subunit and functional characterization of its oligomeric forms. J. Biol. Chem. 263 12986-93 PubMed GONUTS page
  5. Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page
  6. Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page
  7. Aboulwafa, M & Saier, MH Jr (2004) Characterization of soluble enzyme II complexes of the Escherichia coli phosphotransferase system. J. Bacteriol. 186 8453-62 PubMed GONUTS page
  8. Chatterjee, R et al. (2001) Mutation of the ptsG gene results in increased production of succinate in fermentation of glucose by Escherichia coli. Appl. Environ. Microbiol. 67 148-54 PubMed GONUTS page