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HUMAN:COX5A
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | COX5A | |
| Protein Name(s) | Cytochrome c oxidase subunit 5A, mitochondrial
Cytochrome c oxidase polypeptide Va | |
| External Links | ||
| UniProt | P20674 | |
| EMBL | M22760 DQ987236 DQ987237 CR407649 AC125435 CH471136 BC024240 | |
| CCDS | CCDS10273.1 | |
| PIR | JT0342 | |
| RefSeq | NP_004246.2 | |
| UniGene | Hs.401903 | |
| ProteinModelPortal | P20674 | |
| SMR | P20674 | |
| BioGrid | 114778 | |
| IntAct | P20674 | |
| MINT | MINT-1386385 | |
| STRING | 9606.ENSP00000317780 | |
| DrugBank | DB02659 | |
| TCDB | 3.D.4.11.1 | |
| iPTMnet | P20674 | |
| PhosphoSite | P20674 | |
| SwissPalm | P20674 | |
| BioMuta | COX5A | |
| DMDM | 218511986 | |
| DOSAC-COBS-2DPAGE | P20674 | |
| OGP | P20674 | |
| SWISS-2DPAGE | P20674 | |
| UCD-2DPAGE | P20674 | |
| EPD | P20674 | |
| MaxQB | P20674 | |
| PaxDb | P20674 | |
| PRIDE | P20674 | |
| TopDownProteomics | P20674 | |
| DNASU | 9377 | |
| Ensembl | ENST00000322347 ENST00000564811 | |
| GeneID | 9377 | |
| KEGG | hsa:9377 | |
| UCSC | uc002azi.5 | |
| CTD | 9377 | |
| GeneCards | COX5A | |
| HGNC | HGNC:2267 | |
| HPA | HPA027526 | |
| MIM | 603773 | |
| neXtProt | NX_P20674 | |
| PharmGKB | PA26784 | |
| eggNOG | KOG4077 ENOG4111MPD | |
| GeneTree | ENSGT00390000001424 | |
| HOGENOM | HOG000160656 | |
| HOVERGEN | HBG051088 | |
| InParanoid | P20674 | |
| KO | K02264 | |
| OMA | SARCYSH | |
| OrthoDB | EOG74J99R | |
| PhylomeDB | P20674 | |
| TreeFam | TF105062 | |
| Reactome | R-HSA-5628897 R-HSA-611105 | |
| ChiTaRS | COX5A | |
| GenomeRNAi | 9377 | |
| NextBio | 35130 | |
| PRO | PR:P20674 | |
| Proteomes | UP000005640 | |
| Bgee | P20674 | |
| CleanEx | HS_COX5A | |
| ExpressionAtlas | P20674 | |
| Genevisible | P20674 | |
| GO | GO:0070062 GO:0005743 GO:0005751 GO:0043209 GO:0004129 GO:0009055 GO:0046872 GO:0044237 GO:0010467 GO:1902600 GO:0006123 GO:0022904 GO:0044281 GO:0006367 | |
| Gene3D | 1.25.40.40 | |
| InterPro | IPR003204 | |
| PANTHER | PTHR14200 | |
| Pfam | PF02284 | |
| SUPFAM | SSF48479 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:2000378 |
negative regulation of reactive oxygen species metabolic process |
ECO:0000315 |
P |
Figure 3a displays how the knock down of Cox5a led to accumulation of reactive oxygen species in H4 cells. |
complete | |||||
| GO:0010507 |
negative regulation of autophagy |
ECO:0000315 |
P |
Figure 3b displays how the knock down of Cox5a resulted in the induction of autophagy in cells transfected with siRNAs against Cox5a or controls. The autophagy levels were then tested with antibodies against p62m Atg5 (Atg12-Atg5 complex) and LC3. |
complete | |||||
|
part_of |
GO:0005751 |
mitochondrial respiratory chain complex IV |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000367750 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005751 |
mitochondrial respiratory chain complex IV |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000367750 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004129 |
cytochrome-c oxidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000367750 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902600 |
proton transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004129 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902600 |
proton transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004129 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902600 |
proton transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004129 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902600 |
proton transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004129 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004129 |
cytochrome-c oxidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P11240 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P12787 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004129 |
cytochrome-c oxidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004129 |
cytochrome-c oxidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009055 |
electron transfer activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
Reactome:R-HSA-163214 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
Reactome:R-HSA-163214 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Lipinski, MM et al. (2010) Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 107 14164-9 PubMed GONUTS page
- ↑ 2.0 2.1 Oswald, C et al. (2009) Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase. J. Mol. Biol. 389 470-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 Rizzuto, R et al. (1988) Subunit Va of human and bovine cytochrome c oxidase is highly conserved. Gene 69 245-56 PubMed GONUTS page
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