MOUSE:FOXA2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Foxa2 (synonyms: Hnf3b, Tcf-3b, Tcf3b)
Protein Name(s)	Hepatocyte nuclear factor 3-beta HNF-3-beta HNF-3B Forkhead box protein A2
External Links
UniProt	P35583
EMBL	X74937 L10409 AL845297 U04197
CCDS	CCDS16836.1
PIR	B54258
RefSeq	NP_001277994.1 NP_034576.2
UniGene	Mm.938
ProteinModelPortal	P35583
SMR	P35583
IntAct	P35583
PhosphoSite	P35583
MaxQB	P35583
PRIDE	P35583
DNASU	15376
Ensembl	ENSMUST00000047315
GeneID	15376
KEGG	mmu:15376
UCSC	uc008mta.1
CTD	3170
MGI	MGI:1347476
eggNOG	COG5025
GeneTree	ENSGT00760000118904
HOGENOM	HOG000231817
HOVERGEN	HBG006621
InParanoid	P35583
KO	K08035
TreeFam	TF316127
Reactome	REACT_214529
NextBio	288030
PRO	PR:P35583
Proteomes	UP000000589
Bgee	P35583
CleanEx	MM_FOXA2
ExpressionAtlas	P35583
Genevestigator	P35583
GO	GO:0005737 GO:0005634 GO:0003677 GO:0000978 GO:0003705 GO:0001205 GO:0001228 GO:0043565 GO:0003700 GO:0008344 GO:0048646 GO:0009653 GO:0009952 GO:0048468 GO:0021533 GO:0001708 GO:0016568 GO:0061448 GO:0071542 GO:0021904 GO:0009953 GO:0001705 GO:0031018 GO:0060441 GO:0001701 GO:0030324 GO:0060487 GO:2000971 GO:0010719 GO:0033132 GO:0045665 GO:0043433 GO:0000433 GO:0048665 GO:0007389 GO:0040019 GO:2000543 GO:0045666 GO:0045880 GO:0045944 GO:0000432 GO:0045945 GO:0045893 GO:0090009 GO:0030193 GO:0010468 GO:0061178 GO:0019216 GO:0019218 GO:2000976 GO:0006355 GO:0070741 GO:0023019 GO:0032525 GO:0006366
Gene3D	1.10.10.10
InterPro	IPR013638 IPR018533 IPR001766 IPR018122 IPR011991
Pfam	PF00250 PF08430 PF09354
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060303	regulation of nucleosome density	PMID:27058788^[1]	ECO:0000315			P		In figure 5 b, there is decreased low Mnase-seq signal when FoxA2 is deleted. This effect is significant for the FoxA2 strong promoters only whereas it is marginal for the FoxA2 weak promoters.	complete CACAO 11603
involved_in	GO:2000971	negative regulation of detection of glucose	PMID:11875061^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:11875061^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033132	negative regulation of glucokinase activity	PMID:11875061^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061987	negative regulation of transcription from RNA polymerase II promoter by glucose	PMID:11875061^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P14246)\|has_regulation_target:(UniProtKB:P52792)	Seeded From UniProt	complete
involved_in	GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	PMID:11875061^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:B2RUS7)\|has_regulation_target:(UniProtKB:Q61743)	Seeded From UniProt	complete
involved_in	GO:2000543	positive regulation of gastrulation	PMID:11291865^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090009	primitive streak formation	PMID:11291865^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045945	positive regulation of transcription by RNA polymerase III	PMID:15737987^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11291865^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040019	positive regulation of embryonic development	PMID:11291865^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000930906 WB:WBGene00004013	P		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347476 PANTHER:PTN000930906	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 MGI:MGI:1347472 MGI:MGI:1347477 PANTHER:PTN000930906 UniProtKB:O00358 UniProtKB:Q9Y261 ZFIN:ZDB-GENE-000616-15	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 FB:FBgn0003430 FB:FBgn0004895 FB:FBgn0014143 MGI:MGI:1347466 MGI:MGI:1347472 MGI:MGI:1347476 MGI:MGI:1347477 MGI:MGI:1349428 MGI:MGI:1353569 MGI:MGI:1927549 MGI:MGI:95546 PANTHER:PTN000930906 PomBase:SPBC32H8.11 PomBase:SPBC4C3.12 RGD:2807 RGD:2808 RGD:2809 SGD:S000000661 SGD:S000001393 UniProtKB:O00358 UniProtKB:P55317 UniProtKB:P58012 UniProtKB:Q12948 UniProtKB:Q13461 UniProtKB:Q5AS72 UniProtKB:Q99958 UniProtKB:Q9Y261 WB:WBGene00001434 WB:WBGene00001441 WB:WBGene00002601 WB:WBGene00003017 WB:WBGene00004013 WB:WBGene00006853	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 PANTHER:PTN000930906 RGD:621723 UniProtKB:O00358 WB:WBGene00004013 ZFIN:ZDB-GENE-000616-15	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090009	primitive streak formation	PMID:11291865^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857725	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071542	dopaminergic neuron differentiation	PMID:18076286^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857725	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071542	dopaminergic neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061448	connective tissue development	PMID:23383217^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P	results_in_development_of:(EMAPA:18008)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060487	lung epithelial cell differentiation	PMID:15668254^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P	occurs_in:(EMAPA:16728) results_in_acquisition_of_features_of:(CL:0000082)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:15668254^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048665	neuron fate specification	PMID:17596284^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P	occurs_in:(EMAPA:16974) results_in_specification_of:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048665	neuron fate specification	PMID:17922007^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176222,MGI:MGI:2177337	P	occurs_in:(EMAPA:16478) results_in_specification_of:(CL:0000850)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:23383217^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P	results_in_formation_of:(EMAPA:18008)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:10498685^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99783	P	results_in_formation_of:(EMAPA:16072)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048468	cell development	PMID:15680365^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177337,MGI:MGI:2664968	P	occurs_in:(EMAPA:32927) occurs_in:(CL:0000171)	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15539431^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95664	P	has_regulation_target:(MGI:MGI:95674)\|has_regulation_target:(MGI:MGI:95674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9152011^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:87951)\|has_regulation_target:(MGI:MGI:98865)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22696295^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1888519)\|has_regulation_target:(MGI:MGI:1100513)\|has_regulation_target:(MGI:MGI:1349451)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11914369^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:98962)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10859308^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:32874) has_regulation_target:(MGI:MGI:88052)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045880	positive regulation of smoothened signaling pathway	PMID:23383217^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P	regulates_o_occurs_in:(EMAPA:16191)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:17922007^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347476	P	regulates_o_occurs_in:(EMAPA:16478) regulates_o_results_in_acquisition_of_features_of:(CL:0000850)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:17596284^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P	regulates_o_occurs_in:(EMAPA:16974) regulates_o_results_in_acquisition_of_features_of:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:17596284^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177337	P	regulates_o_occurs_in:(EMAPA:16974) regulates_o_results_in_acquisition_of_features_of:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:17922007^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347476	P	occurs_in:(EMAPA:16478) regulates_o_results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:22737085^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:14701942^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:102851)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:11914369^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:98962)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032525	somite rostral/caudal axis specification	PMID:11291865^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857725	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031018	endocrine pancreas development	PMID:15680365^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177337,MGI:MGI:2664968	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031018	endocrine pancreas development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:15668254^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030193	regulation of blood coagulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0023019	signal transduction involved in regulation of gene expression	PMID:18462699^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:9226455^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:23383217^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:18590716^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021533	cell differentiation in hindbrain	PMID:17922007^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347476	P	occurs_in:(EMAPA:16478) results_in_acquisition_of_features_of:(CL:0000850)\|occurs_in(EMAPA:16478) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021533	cell differentiation in hindbrain	PMID:17922007^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176222,MGI:MGI:2177337	P	occurs_in:(EMAPA:16478) results_in_acquisition_of_features_of:(CL:0000850)\|occurs_in(EMAPA:16478) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019218	regulation of steroid metabolic process	PMID:22737085^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019218	regulation of steroid metabolic process	PMID:22737085^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019216	regulation of lipid metabolic process	PMID:22737085^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)\|regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019216	regulation of lipid metabolic process	PMID:22737085^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010719	negative regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:17596284^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347472	P	occurs_in:(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:109619)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:97347)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:1352456)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:95389)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:94876)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:98735)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:109619)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:97347)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:1352456)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:95389)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:94876)\|occurs_in(EMAPA:16974) occurs_in:(CL:0000700) has_regulation_target:(MGI:MGI:98735)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:10498685^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99783	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:10498685^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99783	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009653	anatomical structure morphogenesis	PMID:9226455^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95841	P	has_participant:(EMAPA:16118)\|has_participant:(EMAPA:16272)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:18076286^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857725	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:10498685^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95664	P	occurs_in:(EMAPA:16058)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:25446530^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12488434^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8813084^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16247)\|part_of:(EMAPA:16976)\|part_of:(EMAPA:16903)\|part_of:(EMAPA:16731) part_of:(CL:0000066)\|part_of:(EMAPA:16735) part_of:(CL:0000066)\|part_of:(EMAPA:16851) part_of:(CL:0000066)\|part_of:(EMAPA:16855) part_of:(CL:0000066)\|part_of:(EMAPA:16855) part_of:(CL:0000066)\|part_of:(EMAPA:17655) part_of:(CL:0000066)\|part_of:(EMAPA:17663) part_of:(CL:0000066)\|part_of:(EMAPA:17655) part_of:(CL:0000066)\|part_of:(EMAPA:17663) part_of:(CL:0000066)\|part_of:(EMAPA:17655) part_of:(CL:0000066)\|part_of:(EMAPA:17663) part_of:(CL:0000066)\|part_of:(EMAPA:17655) part_of:(CL:0000066)\|part_of:(EMAPA:17663) part_of:(CL:0000066)\|part_of:(EMAPA:17655) part_of:(CL:0000066)\|part_of:(EMAPA:17663) part_of:(CL:0000066)\|part_of:(EMAPA:17655) part_of:(CL:0000066)\|part_of:(EMAPA:17663) part_of:(CL:0000066)\|part_of:(EMAPA:17655) part_of:(CL:0000066)\|part_of:(EMAPA:17663) part_of:(CL:0000066)\|part_of:(EMAPA:35121) part_of:(CL:0000066)\|part_of:(EMAPA:32693) part_of:(CL:0000066)\|part_of:(EMAPA:16855) part_of:(CL:0000066)\|part_of:(EMAPA:16855) part_of:(CL:0000066)\|part_of:(EMAPA:16855) part_of:(CL:0000066)\|part_of:(EMAPA:16855) part_of:(CL:0000066)\|part_of:(EMAPA:16855) part_of:(CL:0000066)\|part_of:(EMAPA:16855) part_of:(CL:0000066)\|part_of:(EMAPA:16855) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23383217^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16531)\|part_of:(EMAPA:16191)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16364283^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15567715^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16706)\|part_of:(EMAPA:16728)\|part_of:(EMAPA:16715)\|part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12488434^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:22921202^[28]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:98493)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12488434^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11914369^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:98962)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:23117660^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890508	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16912278^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15987774^[31]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:95664)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15485926^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12488434^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001708	cell fate specification	PMID:18076286^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001705	ectoderm formation	PMID:10498685^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99783	P	results_in_formation_of:(EMAPA:16069)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9152011^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22780989^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22696295^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:1888519)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:14701942^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:102851)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:10859308^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:32874) has_regulation_target:(MGI:MGI:88052)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y261	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2808	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013638	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013638	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0070741	response to interleukin-6	PMID:15737987^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Iwafuchi-Doi, M et al. (2016) The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation. Mol. Cell 62 79-91 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Wang, H et al. (2002) Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. J. Biol. Chem. 277 17564-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Kinder, SJ et al. (2001) Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int. J. Dev. Biol. 45 347-55 PubMed GONUTS page
↑ ^4.0 ^4.1 Verschuur, M et al. (2005) A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism. J. Biol. Chem. 280 16763-71 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Kittappa, R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 5 e325 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Maier, JA et al. (2013) Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS ONE 8 e55528 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Wan, H et al. (2005) Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J. Biol. Chem. 280 13809-16 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Ferri, AL et al. (2007) Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development 134 2761-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Jacob, J et al. (2007) Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat. Neurosci. 10 1433-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Perea-Gómez, A et al. (1999) HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development 126 4499-511 PubMed GONUTS page
↑ ^12.0 ^12.1 Lee, CS et al. (2005) Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev. Biol. 278 484-95 PubMed GONUTS page
↑ Ritz-Laser, B et al. (2005) The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol. Endocrinol. 19 759-70 PubMed GONUTS page
↑ ^14.0 ^14.1 Farrington, SM et al. (1997) Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Mech. Dev. 62 197-211 PubMed GONUTS page
↑ ^15.0 ^15.1 Metzakopian, E et al. (2012) Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development 139 2625-34 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Weidenfeld, J et al. (2002) The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J. Biol. Chem. 277 21061-70 PubMed GONUTS page
↑ ^17.0 ^17.1 Antes, TJ et al. (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine. J. Biol. Chem. 275 26637-48 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Bochkis, IM et al. (2012) Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 8 e1002770 PubMed GONUTS page
↑ ^19.0 ^19.1 Gerrish, K et al. (2004) Conserved transcriptional regulatory domains of the pdx-1 gene. Mol. Endocrinol. 18 533-48 PubMed GONUTS page
↑ Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page
↑ ^21.0 ^21.1 Filosa, S et al. (1997) Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development 124 2843-54 PubMed GONUTS page
↑ Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page
↑ Falix, FA et al. (2014) Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev. Biol. 396 201-13 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Kitamura, T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 110 1839-47 PubMed GONUTS page
↑ Zhou, L et al. (1996) Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J. Histochem. Cytochem. 44 1183-93 PubMed GONUTS page
↑ Bort, R et al. (2006) Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev. Biol. 290 44-56 PubMed GONUTS page
↑ Besnard, V et al. (2004) Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues. Gene Expr. Patterns 5 193-208 PubMed GONUTS page
↑ Voss, AK et al. (2012) MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Dev. Cell 23 652-63 PubMed GONUTS page
↑ Fouillade, C et al. (2013) Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler. Thromb. Vasc. Biol. 33 76-86 PubMed GONUTS page
↑ Kyrmizi, I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 20 2293-305 PubMed GONUTS page
↑ Rojas, A et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development 132 3405-17 PubMed GONUTS page
↑ Long, L & Spear, BT (2004) FoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivo. Mol. Cell. Biol. 24 9601-9 PubMed GONUTS page
↑ Faure, AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22 2163-75 PubMed GONUTS page

[PMID:27058788-1] Iwafuchi-Doi, M et al. (2016) The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation. Mol. Cell 62 79-91 PubMed GONUTS page

[PMID:11875061-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Wang, H et al. (2002) Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. J. Biol. Chem. 277 17564-70 PubMed GONUTS page

[PMID:11291865-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Kinder, SJ et al. (2001) Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int. J. Dev. Biol. 45 347-55 PubMed GONUTS page

[PMID:15737987-4] 4.0 ^4.1 Verschuur, M et al. (2005) A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism. J. Biol. Chem. 280 16763-71 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18076286-6] 6.0 ^6.1 ^6.2 Kittappa, R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 5 e325 PubMed GONUTS page

[PMID:23383217-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Maier, JA et al. (2013) Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS ONE 8 e55528 PubMed GONUTS page

[PMID:15668254-8] 8.0 ^8.1 ^8.2 Wan, H et al. (2005) Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J. Biol. Chem. 280 13809-16 PubMed GONUTS page

[PMID:17596284-9] 9.0 ^9.1 ^9.2 ^9.3 Ferri, AL et al. (2007) Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development 134 2761-9 PubMed GONUTS page

[PMID:17922007-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Jacob, J et al. (2007) Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat. Neurosci. 10 1433-9 PubMed GONUTS page

[PMID:10498685-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Perea-Gómez, A et al. (1999) HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development 126 4499-511 PubMed GONUTS page

[PMID:15680365-12] 12.0 ^12.1 Lee, CS et al. (2005) Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev. Biol. 278 484-95 PubMed GONUTS page

[PMID:15539431-13] Ritz-Laser, B et al. (2005) The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol. Endocrinol. 19 759-70 PubMed GONUTS page

[PMID:9152011-14] 14.0 ^14.1 Farrington, SM et al. (1997) Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac. Mech. Dev. 62 197-211 PubMed GONUTS page

[PMID:22696295-15] 15.0 ^15.1 Metzakopian, E et al. (2012) Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development 139 2625-34 PubMed GONUTS page

[PMID:11914369-16] 16.0 ^16.1 ^16.2 Weidenfeld, J et al. (2002) The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J. Biol. Chem. 277 21061-70 PubMed GONUTS page

[PMID:10859308-17] 17.0 ^17.1 Antes, TJ et al. (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine. J. Biol. Chem. 275 26637-48 PubMed GONUTS page

[PMID:22737085-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Bochkis, IM et al. (2012) Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 8 e1002770 PubMed GONUTS page

[PMID:14701942-19] 19.0 ^19.1 Gerrish, K et al. (2004) Conserved transcriptional regulatory domains of the pdx-1 gene. Mol. Endocrinol. 18 533-48 PubMed GONUTS page

[PMID:18462699-20] Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page

[PMID:9226455-21] 21.0 ^21.1 Filosa, S et al. (1997) Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development 124 2843-54 PubMed GONUTS page

[PMID:18590716-22] Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page

[PMID:25446530-23] Falix, FA et al. (2014) Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev. Biol. 396 201-13 PubMed GONUTS page

[PMID:12488434-24] 24.0 ^24.1 ^24.2 ^24.3 Kitamura, T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 110 1839-47 PubMed GONUTS page

[PMID:8813084-25] Zhou, L et al. (1996) Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J. Histochem. Cytochem. 44 1183-93 PubMed GONUTS page

[PMID:16364283-26] Bort, R et al. (2006) Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev. Biol. 290 44-56 PubMed GONUTS page

[PMID:15567715-27] Besnard, V et al. (2004) Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues. Gene Expr. Patterns 5 193-208 PubMed GONUTS page

[PMID:22921202-28] Voss, AK et al. (2012) MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Dev. Cell 23 652-63 PubMed GONUTS page

[PMID:23117660-29] Fouillade, C et al. (2013) Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler. Thromb. Vasc. Biol. 33 76-86 PubMed GONUTS page

[PMID:16912278-30] Kyrmizi, I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 20 2293-305 PubMed GONUTS page

[PMID:15987774-31] Rojas, A et al. (2005) Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development 132 3405-17 PubMed GONUTS page

[PMID:15485926-32] Long, L & Spear, BT (2004) FoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivo. Mol. Cell. Biol. 24 9601-9 PubMed GONUTS page

[PMID:22780989-33] Faure, AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22 2163-75 PubMed GONUTS page

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MOUSE:FOXA2

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