Category:MichSt14A 22

Figure 4 C shows that PON3 diminishes mitochondrial superoxide formation when compared to PON3 knockout cells.

Figure 4 a. Results from three different tissues in adult mice. In the wild-type (+/+) genotype, Lc3 synthase gene expression was detected mainly in spleen and was weakly positive in brain and liver. Lc3 synthase expression was decreased in the heterozygote (+/-) and completely knocked out in the homozygote (-/-). Lc3 synthase is a step in the ganglioside biosynthetic process.

Figure 3: B) Representative peripheral blood films from both genotypes showing the presence of anemia, thrombocytopenia, and poikilocytosis in the Jak2 cKO mice, but not the controls. (C) Histologic sections of spleen found an abnormal splenic architecture in the Jak2 cKO mice characterized by atrophied and disorganized white pulp.(D) Representative bone marrow sections from both genotypes indicating increased adipose deposits in the Jak2 cKO mice, but not the controls. (E) Representative liver sections showing diffuse centrolobular vacuolar degeneration in the Jak2 cKO tissue, but not in the control tissue.

Figure 8. Oxidative metabolism is impaired in the skeletal muscle of chow-fed MαKO mice. Skeletal muscle (quadriceps) was collected from 6-7 months old, chow-fed

mice after overnight fasting. The expression of genes related to FA oxidation, muscle types, and energy expenditure were measured by Q-PCR (n=5 per group) (a). Proteins related to FA oxidation in skeletal muscle were measured by Western blotting.

Figure 3 shows that protein ALDH2 has decreased myocardial activity in mice given a high-fat diet/ low-dose streptozotocin.

Figure 8 shows activity of ALDH2 correlates inversely with cardiomyocyte hypertrophy.