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MOUSE:B3GN5

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) B3gnt5
Protein Name(s) Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

Lactotriaosylceramide synthase Lc(3)Cer synthase Lc3 synthase UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5 BGnT-5 Beta-1,3-Gn-T5 Beta-1,3-N-acetylglucosaminyltransferase 5 Beta3Gn-T5

External Links
UniProt Q8BGY6
EMBL AB059620
AY029203
AK032911
AK048010
AK083839
BC063076
CCDS CCDS28040.1
RefSeq NP_001152879.1
NP_001152880.1
NP_473393.2
XP_006521769.1
XP_006521770.1
UniGene Mm.33935
ProteinModelPortal Q8BGY6
STRING 10090.ENSMUSP00000112624
CAZy GT31
MaxQB Q8BGY6
PRIDE Q8BGY6
Ensembl ENSMUST00000079780
ENSMUST00000119468
ENSMUST00000121344
ENSMUST00000164397
GeneID 108105
KEGG mmu:108105
UCSC uc007ypc.2
CTD 84002
MGI MGI:2137302
eggNOG NOG253164
GeneTree ENSGT00760000118879
HOGENOM HOG000064519
HOVERGEN HBG101684
InParanoid Q8BGY6
KO K03766
OMA TWGNEKY
OrthoDB EOG7C2R1D
PhylomeDB Q8BGY6
TreeFam TF318639
Reactome REACT_198517
UniPathway UPA00378
NextBio 360080
PRO PR:Q8BGY6
Proteomes UP000000589
Bgee Q8BGY6
Genevestigator Q8BGY6
GO GO:0000139
GO:0016021
GO:0005622
GO:0008457
GO:0008378
GO:0047256
GO:0008917
GO:0007417
GO:0009103
GO:0006486
GO:0030148
InterPro IPR002659
PANTHER PTHR11214
Pfam PF01762

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001574

ganglioside biosynthetic process

PMID:2998480[1]

ECO:0000314

P

Figure 4 a. Results from three different tissues in adult mice. In the wild-type (+/+) genotype, Lc3 synthase gene expression was detected mainly in spleen and was weakly positive in brain and liver. Lc3 synthase expression was decreased in the heterozygote (+/-) and completely knocked out in the homozygote (-/-). Lc3 synthase is a step in the ganglioside biosynthetic process.

complete
CACAO 9880

enables

GO:0008457

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9BYG0

F

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9BYG0

P

Seeded From UniProt

complete

involved_in

GO:0030311

poly-N-acetyllactosamine biosynthetic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000130272
UniProtKB:Q7Z7M8
UniProtKB:Q9C0J1
UniProtKB:Q9NY97
UniProtKB:Q9Y2A9

P

Seeded From UniProt

complete

enables

GO:0008532

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000130272
UniProtKB:Q9C0J1
UniProtKB:Q9NY97
UniProtKB:Q9Y2A9

F

Seeded From UniProt

complete

enables

GO:0008457

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000130313
UniProtKB:Q9BYG0

F

Seeded From UniProt

complete

enables

GO:0008376

acetylgalactosaminyltransferase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000130250
WB:WBGene00000270

F

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000130313
RGD:70955

P

Seeded From UniProt

complete

involved_in

GO:0006486

protein glycosylation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1889505
PANTHER:PTN000879966
UniProtKB:Q8NCR0
ZFIN:ZDB-GENE-050522-358

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000879966
PomBase:SPBC1921.06c
TAIR:locus:2009665
TAIR:locus:2029471
TAIR:locus:2057442
TAIR:locus:2081071
TAIR:locus:2086370
TAIR:locus:2154247
TAIR:locus:2200660
TAIR:locus:2207225
UniProtKB:A7XDQ9
UniProtKB:Q6UX72
WB:WBGene00005020

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000879966
UniProtKB:A7XDQ9
UniProtKB:Q8NCR0

C

Seeded From UniProt

complete

enables

GO:0008457

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BYG0

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007417

central nervous system development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BYG0

P

Seeded From UniProt

complete

enables

GO:0008457

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BYG0
ensembl:ENSP00000316173

F

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BYG0
ensembl:ENSP00000316173

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99NB2
ensembl:ENSRNOP00000067153

P

Seeded From UniProt

complete

involved_in

GO:0006486

protein glycosylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002659

P

Seeded From UniProt

complete

enables

GO:0008378

galactosyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002659

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002659

C

Seeded From UniProt

complete

enables

GO:0047256

lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.206

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030148

sphingolipid biosynthetic process

PMID:11384981[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0134

C

Seeded From UniProt

complete

involved_in

GO:0006486

protein glycosylation

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00378

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Redman, CM & Avellino, G (1985) Effects of canavanine on the secretion of plasma proteins by Hep G2 cells. Biochim. Biophys. Acta 847 198-206 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Henion, TR et al. (2001) Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. J. Biol. Chem. 276 30261-9 PubMed GONUTS page
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