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MOUSE:ALDH2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Aldh2 (synonyms: Ahd-1, Ahd1) | |
| Protein Name(s) | Aldehyde dehydrogenase, mitochondrial
AHD-M1 ALDH class 2 ALDH-E2 ALDHI | |
| External Links | ||
| UniProt | P47738 | |
| EMBL | U07235 S71509 BC005476 Z32545 | |
| CCDS | CCDS19638.1 | |
| PIR | I48966 | |
| RefSeq | NP_033786.1 | |
| UniGene | Mm.284446 | |
| ProteinModelPortal | P47738 | |
| SMR | P47738 | |
| IntAct | P47738 | |
| MINT | MINT-1859437 | |
| PhosphoSite | P47738 | |
| REPRODUCTION-2DPAGE | P47738 | |
| SWISS-2DPAGE | P47738 | |
| UCD-2DPAGE | P47738 | |
| MaxQB | P47738 | |
| PaxDb | P47738 | |
| PRIDE | P47738 | |
| Ensembl | ENSMUST00000031411 | |
| GeneID | 11669 | |
| KEGG | mmu:11669 | |
| UCSC | uc008zjt.1 | |
| CTD | 217 | |
| MGI | MGI:99600 | |
| eggNOG | COG1012 | |
| HOGENOM | HOG000271505 | |
| HOVERGEN | HBG000097 | |
| InParanoid | P47738 | |
| KO | K00128 | |
| OMA | HLIMEAA | |
| OrthoDB | EOG7PS1F7 | |
| PhylomeDB | P47738 | |
| TreeFam | TF300455 | |
| Reactome | REACT_231054 REACT_260489 | |
| UniPathway | UPA00780 | |
| ChiTaRS | Aldh2 | |
| NextBio | 279291 | |
| PRO | PR:P47738 | |
| Proteomes | UP000000589 | |
| Bgee | P47738 | |
| CleanEx | MM_ALDH2 | |
| ExpressionAtlas | P47738 | |
| Genevestigator | P47738 | |
| GO | GO:0005759 GO:0005739 GO:0004029 GO:0006068 | |
| Gene3D | 3.40.309.10 3.40.605.10 | |
| InterPro | IPR016161 IPR016163 IPR016160 IPR029510 IPR016162 IPR015590 | |
| Pfam | PF00171 | |
| SUPFAM | SSF53720 | |
| PROSITE | PS00070 PS00687 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008106 |
alcohol dehydrogenase (NADP+) activity |
ECO:0000314 |
F |
Figure 3 shows that protein ALDH2 has decreased myocardial activity in mice given a high-fat diet/ low-dose streptozotocin. Figure 8 shows activity of ALDH2 correlates inversely with cardiomyocyte hypertrophy. |
complete | |||||
|
enables |
GO:0051287 |
NAD binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0012036 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070404 |
NADH binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69219 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69219 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69219 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373)|part_of:(EMAPA:16105) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69219 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69219 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR015590 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016620 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR015590 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043878 |
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006068 |
ethanol catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00780 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Mali, VR et al. (2014) Impairment of aldehyde dehydrogenase-2 by 4-hydroxy-2-nonenal adduct formation and cardiomyocyte hypertrophy in mice fed a high-fat diet and injected with low-dose streptozotocin. Exp. Biol. Med. (Maywood) 239 610-8 PubMed GONUTS page
- ↑ Bateman, OA et al. (2003) Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Biochemistry 42 4349-56 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
- ↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
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