Category:GO:0035582 ! sequestering of BMP in extracellular matrix

name: sequestering of BMP in extracellular matrix
namespace: biological_process
def: "Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins." [GOC:BHF, PMID:20855508]
comment: Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
synonym: "BMP sequestration in the ECM" EXACT [PMID:20855508]
synonym: "negative regulation of BMP signaling pathway by extracellular sequestering of BMP" EXACT [GOC:bf]
synonym: "negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP" EXACT [GOC:mah]
synonym: "negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein" EXACT []
is_a: GO:0030514 ! negative regulation of BMP signaling pathway
is_a: GO:0035581 ! sequestering of extracellular ligand from receptor
is_a: GO:0071694 ! maintenance of protein location in extracellular region

AmiGO <GOterm>GO:0035582</GOterm>
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