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MOUSE:DAND5
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Dand5 (synonyms: Cerl2, Sp1) | |
| Protein Name(s) | DAN domain family member 5
Cerberus-like protein 2 Cerl-2 | |
| External Links | ||
| UniProt | Q76LW6 | |
| EMBL | AY387409 AB070694 BC115659 | |
| CCDS | CCDS22477.1 | |
| RefSeq | NP_957679.1 | |
| UniGene | Mm.304252 | |
| ProteinModelPortal | Q76LW6 | |
| SMR | Q76LW6 | |
| BioGrid | 204764 | |
| PRIDE | Q76LW6 | |
| Ensembl | ENSMUST00000065539 | |
| GeneID | 23863 | |
| KEGG | mmu:23863 | |
| UCSC | uc009mnh.1 | |
| CTD | 199699 | |
| MGI | MGI:1344365 | |
| eggNOG | NOG38827 | |
| GeneTree | ENSGT00530000063926 | |
| HOGENOM | HOG000112140 | |
| HOVERGEN | HBG094958 | |
| InParanoid | Q76LW6 | |
| OMA | RNHLCFG | |
| OrthoDB | EOG7VX8X6 | |
| PhylomeDB | Q76LW6 | |
| TreeFam | TF106445 | |
| NextBio | 303573 | |
| PRO | PR:Q76LW6 | |
| Proteomes | UP000000589 | |
| Bgee | Q76LW6 | |
| CleanEx | MM_DAND5 MM_SP1 | |
| Genevestigator | Q76LW6 | |
| GO | GO:0005576 GO:0016015 GO:0003283 GO:0061371 GO:0003140 GO:0007368 GO:0030514 GO:1900108 GO:1900146 GO:0030512 GO:1900164 GO:0017015 GO:0038101 GO:0003281 | |
| InterPro | IPR016860 IPR006207 IPR004133 | |
| Pfam | PF03045 | |
| PIRSF | PIRSF027807 | |
| SMART | SM00041 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1900164 |
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900146 |
negative regulation of nodal signaling pathway involved in determination of left/right asymmetry |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900108 |
negative regulation of nodal signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061371 |
determination of heart left/right asymmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038101 |
sequestering of nodal from receptor via nodal binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030514 |
negative regulation of BMP signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016015 |
morphogen activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003283 |
atrial septum development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003281 |
ventricular septum development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003140 |
determination of left/right asymmetry in lateral mesoderm |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900176 |
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000392278 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061371 |
determination of heart left/right asymmetry |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1344365 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035582 |
sequestering of BMP in extracellular matrix |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1201414 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0023019 |
signal transduction involved in regulation of gene expression |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1201414 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016015 |
morphogen activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1344365 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1201414 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97359 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007368 |
determination of left/right symmetry |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97359 |
P |
has_participant:(EMAPA:16039) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0007368 |
determination of left/right symmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3056132 |
P |
has_participant:(EMAPA:16039) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0016015 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0016015 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Tavares, AT et al. (2007) Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development 134 2051-60 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Marques, S et al. (2004) The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev. 18 2342-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Mastrangeli, R et al. () ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda. Eur J Dermatol 13 560-70 PubMed GONUTS page
- ↑ Pearce, JJ et al. (1999) A mouse cerberus/Dan-related gene family. Dev. Biol. 209 98-110 PubMed GONUTS page
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- GO:1900146 ! obsolete negative regulation of nodal signaling pathway involved in determination of left/right asymmetry
- GO:1900176 ! obsolete negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
- GO:1900164 ! obsolete nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
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