GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:15466485
| Citation |
Marques, S, Borges, AC, Silva, AC, Freitas, S, Cordenonsi, M and Belo, JA (2004) The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev. 18:2342-7 |
|---|---|
| Abstract |
Correct establishment of the left/right (L/R) body asymmetry in the mouse embryo requires asymmetric activation of the evolutionarily conserved Nodal signaling cascade in the left lateral plate mesoderm (L-LPM). Furthermore, the presence of Nodal in the node is essential for its own expression in the L-LPM. Here, we have characterized the function of cerl-2, a novel Nodal antagonist, which displays a unique asymmetric expression on the right side of the mouse node. cerl-2 knockout mice display multiple laterality defects including randomization of the L/R axis. These defects can be partially rescued by removing one nodal allele. Our results demonstrate that Cerl-2 plays a key role in restricting the Nodal signaling pathway toward the left side of the mouse embryo by preventing its activity in the right side. |
| Links |
PubMed PMC522983 Online version:10.1101/gad.306504 |
| Keywords |
Animals; Base Sequence; Body Patterning/physiology; DNA Primers; Mice; Mice, Knockout; Nodal Protein; Transforming Growth Factor beta/antagonists & inhibitors |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
