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HUMAN:DAND5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DAND5 (synonyms: CER2, CKTSF1B3, GREM3, SP1)
Protein Name(s) DAN domain family member 5

Cerberus-like protein 2 Cerl-2 Cysteine knot superfamily 1, BMP antagonist 3 Gremlin-3

External Links
UniProt Q8N907
EMBL AB070695
AK095926
BC101800
BC113476
CCDS CCDS12291.1
RefSeq NP_689867.1
UniGene Hs.331981
ProteinModelPortal Q8N907
SMR Q8N907
STRING 9606.ENSP00000323155
DMDM 74729571
MaxQB Q8N907
PaxDb Q8N907
PRIDE Q8N907
Ensembl ENST00000317060
GeneID 199699
KEGG hsa:199699
UCSC uc002mwc.1
CTD 199699
GeneCards GC19P013081
HGNC HGNC:26780
HPA HPA049472
MIM 609068
neXtProt NX_Q8N907
PharmGKB PA134875268
eggNOG NOG38827
GeneTree ENSGT00530000063926
HOGENOM HOG000112140
HOVERGEN HBG094958
InParanoid Q8N907
OMA RNHLCFG
PhylomeDB Q8N907
TreeFam TF106445
SignaLink Q8N907
GenomeRNAi 199699
NextBio 89693
PRO PR:Q8N907
Proteomes UP000005640
Bgee Q8N907
CleanEx HS_DAND5
HS_SP1
ExpressionAtlas Q8N907
Genevestigator Q8N907
GO GO:0005576
GO:0016015
GO:0003283
GO:0061371
GO:0003140
GO:0030514
GO:1900108
GO:0030512
GO:0038101
GO:0003281
InterPro IPR016860
IPR004133
Pfam PF03045
PIRSF PIRSF027807

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1900108

negative regulation of nodal signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76LW6

P

Seeded From UniProt

complete

involved_in

GO:0061371

determination of heart left/right asymmetry

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76LW6

P

Seeded From UniProt

complete

involved_in

GO:0038101

sequestering of nodal from receptor via nodal binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76LW6

P

Seeded From UniProt

complete

involved_in

GO:0030514

negative regulation of BMP signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76LW6

P

Seeded From UniProt

complete

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76LW6

P

Seeded From UniProt

complete

enables

GO:0016015

morphogen activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76LW6

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:15466485[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0003283

atrial septum development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76LW6

P

Seeded From UniProt

complete

involved_in

GO:0003281

ventricular septum development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76LW6

P

Seeded From UniProt

complete

involved_in

GO:0003140

determination of left/right asymmetry in lateral mesoderm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q76LW6

P

Seeded From UniProt

complete

involved_in

GO:1900176

negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000392278
UniProtKB:Q9PWB0

P

Seeded From UniProt

complete

involved_in

GO:0061371

determination of heart left/right asymmetry

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1344365
PANTHER:PTN000392278

P

Seeded From UniProt

complete

involved_in

GO:0035582

sequestering of BMP in extracellular matrix

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1201414
PANTHER:PTN000392278
UniProtKB:O95813

P

Seeded From UniProt

complete

involved_in

GO:0023019

signal transduction involved in regulation of gene expression

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1201414
PANTHER:PTN000392278

P

Seeded From UniProt

complete

enables

GO:0016015

morphogen activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1344365
PANTHER:PTN000392278
UniProtKB:O95813

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1201414
PANTHER:PTN000392278
UniProtKB:Q9PWB0

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016015

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016015

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016015

P

Seeded From UniProt

complete

involved_in

GO:1900108

negative regulation of nodal signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

involved_in

GO:0061371

determination of heart left/right asymmetry

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

involved_in

GO:0038101

sequestering of nodal from receptor via nodal binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

involved_in

GO:0030514

negative regulation of BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

involved_in

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

enables

GO:0016015

morphogen activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

F

Seeded From UniProt

complete

involved_in

GO:0007368

determination of left/right symmetry

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

involved_in

GO:0003283

atrial septum development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

involved_in

GO:0003281

ventricular septum development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

involved_in

GO:0003140

determination of left/right asymmetry in lateral mesoderm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q76LW6
ensembl:ENSMUSP00000070057

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Marques, S et al. (2004) The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev. 18 2342-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page