CHICK:CER1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CER1
Protein Name(s)	Cerberus
External Links
UniProt	Q9PWB0
EMBL	AF139721
UniGene	Gga.355
STRING	9031.ENSGALP00000008711
Ensembl	ENSGALT00000008725
eggNOG	NOG40714
GeneTree	ENSGT00530000063926
HOGENOM	HOG000231309
HOVERGEN	HBG050902
InParanoid	Q9PWB0
OMA	PYRKDAK
OrthoDB	EOG7VX8X6
PhylomeDB	Q9PWB0
TreeFam	TF106445
Reactome	REACT_310846 REACT_314342 REACT_326856
PRO	PR:Q9PWB0
Proteomes	UP000000539
GO	GO:0005615 GO:0016015 GO:0009948 GO:0030282 GO:0042074 GO:0048263 GO:0003140 GO:0003419 GO:0001947 GO:0048382 GO:1902813 GO:0008285 GO:0010629 GO:1900176 GO:0007399 GO:0010628 GO:1901207 GO:0023019 GO:0001657
InterPro	IPR016860 IPR006207 IPR004133
Pfam	PF03045
PIRSF	PIRSF027807
SMART	SM00041
PROSITE	PS01225

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1900176	negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	PMID:17507406^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048382	mesendoderm development	PMID:17507406^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	PMID:17507406^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:17507406^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902813	negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry	PMID:10499580^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901207	regulation of heart looping	PMID:10499580^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:10499580^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:10499580^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10499580^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1900176	negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000392278 UniProtKB:Q9PWB0	P	Seeded From UniProt	complete
involved_in	GO:0061371	determination of heart left/right asymmetry	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1344365 PANTHER:PTN000392278	P	Seeded From UniProt	complete
involved_in	GO:0035582	sequestering of BMP in extracellular matrix	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1201414 PANTHER:PTN000392278 UniProtKB:O95813	P	Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1201414 PANTHER:PTN000392278	P	Seeded From UniProt	complete
enables	GO:0016015	morphogen activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1344365 PANTHER:PTN000392278 UniProtKB:O95813	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1201414 PANTHER:PTN000392278 UniProtKB:Q9PWB0	C	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016015	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016015	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:2000381	negative regulation of mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	F	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0035582	sequestering of BMP in extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0032926	negative regulation of activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	C	Seeded From UniProt	complete
involved_in	GO:0003419	growth plate cartilage chondrocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:2000381	negative regulation of mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95813 ensembl:ENSP00000370297	P	Seeded From UniProt	complete
involved_in	GO:0048263	determination of dorsal identity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95813 ensembl:ENSP00000370297	P	Seeded From UniProt	complete
enables	GO:0036122	BMP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95813 ensembl:ENSP00000370297	F	Seeded From UniProt	complete
involved_in	GO:0035582	sequestering of BMP in extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95813 ensembl:ENSP00000370297	P	Seeded From UniProt	complete
involved_in	GO:0032926	negative regulation of activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95813 ensembl:ENSP00000370297	P	Seeded From UniProt	complete
involved_in	GO:0030282	bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95813 ensembl:ENSP00000370297	P	Seeded From UniProt	complete
enables	GO:0016015	morphogen activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95813 ensembl:ENSP00000370297	F	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95813 ensembl:ENSP00000370297	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Tavares, AT et al. (2007) Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development 134 2051-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Rodríguez Esteban, C et al. (1999) The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature 401 243-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17507406-1] 1.0 ^1.1 ^1.2 ^1.3 Tavares, AT et al. (2007) Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development 134 2051-60 PubMed GONUTS page

[PMID:10499580-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Rodríguez Esteban, C et al. (1999) The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature 401 243-51 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:CER1

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