HUMAN:CER1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CER1 (synonyms: DAND4)
Protein Name(s)	Cerberus Cerberus-related protein DAN domain family member 4
External Links
UniProt	O95813
EMBL	AF090189 AF400435 AL390732 BC069371 BC069405 BC069491 BC069503
CCDS	CCDS6476.1
RefSeq	NP_005445.1
UniGene	Hs.248204
ProteinModelPortal	O95813
SMR	O95813
BioGrid	114753
STRING	9606.ENSP00000370297
PhosphoSite	O95813
PaxDb	O95813
PRIDE	O95813
DNASU	9350
Ensembl	ENST00000380911
GeneID	9350
KEGG	hsa:9350
UCSC	uc003zlj.3
CTD	9350
GeneCards	GC09M014710
H-InvDB	HIX0034784
HGNC	HGNC:1862
HPA	HPA019917
MIM	603777
neXtProt	NX_O95813
PharmGKB	PA26417
eggNOG	NOG40714
GeneTree	ENSGT00530000063926
HOGENOM	HOG000231309
HOVERGEN	HBG050902
InParanoid	O95813
KO	K01645
OMA	CFGKCGS
OrthoDB	EOG7VX8X6
PhylomeDB	O95813
TreeFam	TF106445
Reactome	REACT_111057 REACT_111059 REACT_12034
GeneWiki	Cerberus_(protein)
GenomeRNAi	9350
NextBio	35013
PRO	PR:O95813
Proteomes	UP000005640
Bgee	O95813
CleanEx	HS_CER1
Genevestigator	O95813
GO	GO:0005576 GO:0005615 GO:0036122 GO:0016015 GO:0042803 GO:0009948 GO:0009952 GO:0030509 GO:0030282 GO:0042074 GO:0071773 GO:0048263 GO:0007369 GO:0003419 GO:0032926 GO:0030514 GO:0008285 GO:2000381 GO:0007399 GO:0035582 GO:0023019 GO:0001657
InterPro	IPR016860 IPR006207 IPR004133
Pfam	PF03045
PIRSF	PIRSF027807
SMART	SM00041
PROSITE	PS01225

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2000381	negative regulation of mesoderm development	PMID:9660951^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000381	negative regulation of mesoderm development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:16798745^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B0BN87	P	Seeded From UniProt	complete
involved_in	GO:0048263	determination of dorsal identity	PMID:9660951^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	F	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:10049596^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
enables	GO:0036122	BMP binding	PMID:9660951^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035582	sequestering of BMP in extracellular matrix	PMID:9660951^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035582	sequestering of BMP in extracellular matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:0032926	negative regulation of activin receptor signaling pathway	PMID:9660951^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032926	negative regulation of activin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	PMID:10049596^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:0030282	bone mineralization	PMID:19113921^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	PMID:10049596^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
enables	GO:0016015	morphogen activity	PMID:9660951^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:10049596^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	PMID:10049596^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:10049596^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:9660951^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	PMID:10049596^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:10049596^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	C	Seeded From UniProt	complete
involved_in	GO:0003419	growth plate cartilage chondrocyte proliferation	PMID:19113921^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55233	P	Seeded From UniProt	complete
involved_in	GO:1900176	negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000392278 UniProtKB:Q9PWB0	P	Seeded From UniProt	complete
involved_in	GO:0061371	determination of heart left/right asymmetry	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1344365 PANTHER:PTN000392278	P	Seeded From UniProt	complete
involved_in	GO:0035582	sequestering of BMP in extracellular matrix	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1201414 PANTHER:PTN000392278 UniProtKB:O95813	P	Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1201414 PANTHER:PTN000392278	P	Seeded From UniProt	complete
enables	GO:0016015	morphogen activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1344365 PANTHER:PTN000392278 UniProtKB:O95813	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1201414 PANTHER:PTN000392278 UniProtKB:Q9PWB0	C	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016015	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016015	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BN87 ensembl:ENSRNOP00000014008	P	Seeded From UniProt	complete
involved_in	GO:2000381	negative regulation of mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	F	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0035582	sequestering of BMP in extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0032926	negative regulation of activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0023019	signal transduction involved in regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	C	Seeded From UniProt	complete
involved_in	GO:0003419	growth plate cartilage chondrocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O55233 ensembl:ENSMUSP00000048607	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	Reactome:R-HSA-201451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-201810	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hsu, DR et al. (1998) The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol. Cell 1 673-83 PubMed GONUTS page
↑ Simic, P et al. (2006) Systemically administered bone morphogenetic protein-6 restores bone in aged ovariectomized rats by increasing bone formation and suppressing bone resorption. J. Biol. Chem. 281 25509-21 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Lah, M et al. (1999) Human cerberus related gene CER1 maps to chromosome 9. Genomics 55 364-6 PubMed GONUTS page
↑ ^4.0 ^4.1 Tang, PL et al. (2009) Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women. J. Bone Miner. Res. 24 1013-21 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9660951-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hsu, DR et al. (1998) The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol. Cell 1 673-83 PubMed GONUTS page

[PMID:16798745-2] Simic, P et al. (2006) Systemically administered bone morphogenetic protein-6 restores bone in aged ovariectomized rats by increasing bone formation and suppressing bone resorption. J. Biol. Chem. 281 25509-21 PubMed GONUTS page

[PMID:10049596-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Lah, M et al. (1999) Human cerberus related gene CER1 maps to chromosome 9. Genomics 55 364-6 PubMed GONUTS page

[PMID:19113921-4] 4.0 ^4.1 Tang, PL et al. (2009) Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women. J. Bone Miner. Res. 24 1013-21 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:CER1

Contents

Annotations

Notes

References

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