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Category:GO:0015012 ! heparan sulfate proteoglycan biosynthetic process
name: heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate)." [PMID:27241222]
synonym: "heparan sulfate proteoglycan anabolism" EXACT []
synonym: "heparan sulfate proteoglycan biosynthesis" EXACT []
synonym: "heparan sulfate proteoglycan formation" EXACT []
synonym: "heparan sulfate proteoglycan synthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process" EXACT []
synonym: "heparin proteoglycan biosynthetic process" RELATED []
xref: MetaCyc:PWY-6558
is_a: GO:0030166 ! proteoglycan biosynthetic process
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
is_a: GO:0180064 ! protein O-linked xylosylation
AmiGO
<GOterm>GO:0015012</GOterm>
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