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RefGenome Electronic Jamboree 2009-02 CAD
See the talk page for tips on editing the tables and for misc. discussion.
Orthoset
EcoliWiki has included the carA gene product annotations. The CarA gene product is a subunit of the E. coli carbamoyl phosphate synthetase, but was not included in the ortholog set.
Participants
| Name | Group | Organism(s)/Genome(s) | Notes |
|---|---|---|---|
|
Ruth Lovering |
BHF-UCL |
Human |
very few papers describe human protein, have annotated hamster protein and used this for ISS |
|
Susan Tweedie |
flyBase |
D. melanogaster |
|
|
Varsha Khodiyar |
BHF-UCL |
Human |
|
|
Harold Drabkin |
MGI |
Mouse |
Doing ISO to golden hamster protein. |
|
Brenley McIntosh |
ecoliwiki |
E. coli |
P00968 (carB) Carbamoyl-phosphate synthase large chain |
|
Stan Laulederkind |
RGD |
Rat |
|
|
Debby Siegele |
ecoliwiki |
E. coli |
P00968 (carB) Carbamoyl-phosphate synthase large chain |
|
Rachael Huntley |
GOA |
Human |
CAD (P27708) |
|
Lakshmi Pillai |
AgBase |
G. gallus |
No ortholog |
|
Kimberly Van Auken |
WormBase |
C. elegans |
pyr-1 (WBGene00004259) |
|
Seval Ozkan |
AgBase |
other |
|
|
Petra Fey |
dictyBase |
D. discoideum |
Noticed now that dicty enzyme is rather CAD than CPS |
| edit table |
CAD
<ejamb>573c5f77b3a094817c4e1c4a6f9b2c99.274990.C499c10bd9e5f0
CAD</ejamb>
| Group | Organism | Gene | Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
FlyBase |
Drosophila |
r |
GO:0004088 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
|
FlyBase |
Drosophila |
r |
GO:0004070 |
aspartate carbamoyltransferase activity |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
|
FlyBase |
Drosophila |
r |
GO:0006207 |
'de novo' pyrimidine base biosynthetic process |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
|
GOA |
Human |
CAD |
GO:0019899 |
enzyme binding |
IPI |
Q99638 |
F |
complete | |||
|
BHF-UCL |
Human |
CAD |
GO:0005829 |
cytosol |
IDA |
C |
complete | ||||
|
BHF-UCL |
Human |
CAD |
GO:0005634 |
nucleus |
IDA |
C |
complete | ||||
|
BHF-UCL |
Human |
CAD |
GO:0016363 |
nuclear matrix |
IDA |
C |
complete | ||||
|
BHF-UCL |
Human |
CAD |
GO:0018107 |
peptidyl-threonine phosphorylation |
ISS: Inferred from Sequence or Structural Similarity |
P08955 |
P |
ISS from hamster protein |
complete | ||
|
BHF-UCL |
Human |
CAD |
GO:0046777 |
protein amino acid autophosphorylation |
ISS: Inferred from Sequence or Structural Similarity |
P08955 |
P |
ISS from hamster protein |
complete | ||
|
BHF-UCL |
Human |
CAD |
GO:0006207 |
'de novo' pyrimidine base biosynthetic process |
ISS: Inferred from Sequence or Structural Similarity |
P08955 |
P |
ISS from hamster protein |
complete | ||
|
BHF-UCL |
Human |
CAD |
GO:0004070 |
aspartate carbamoyltransferase activity |
ISS: Inferred from Sequence or Structural Similarity |
P08955 |
F |
ISS from hamster protein |
complete | ||
|
BHF-UCL |
Human |
CAD |
GO:0005524 |
ATP binding |
ISS: Inferred from Sequence or Structural Similarity |
P08955 |
F |
ISS from hamster protein |
complete | ||
|
BHF-UCL |
Human |
CAD |
GO:0016597 |
amino acid binding |
ISS: Inferred from Sequence or Structural Similarity |
P08955 |
F |
ISS from hamster protein |
complete | ||
|
BHF-UCL |
Human |
CAD |
GO:0004088 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
ISS: Inferred from Sequence or Structural Similarity |
P08955 |
F |
ISS from hamster protein |
complete | ||
|
BHF-UCL |
Human |
CAD |
GO:0004151 |
dihydroorotase activity |
ISS: Inferred from Sequence or Structural Similarity |
P08955 |
F |
ISS from hamster protein |
complete | ||
|
FlyBase |
Drosophila |
r |
GO:0004151 |
dihydroorotase activity |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
|
FlyBase |
Drosophila |
r |
GO:0004070 |
aspartate carbamoyltransferase activity |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
|
FlyBase |
Drosophila |
r |
GO:0004088 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
BIOSIS:11600041556 |
IDA: Inferred from Direct Assay |
F |
complete | |||
|
FlyBase |
Drosophila |
r |
GO:0016597 |
amino acid binding |
BIOSIS:11600041556 |
IC: Inferred by Curator |
GO:0004088 |
F |
Or IDA? NTR: glutamine binding? |
complete | |
|
FlyBase |
Drosophila |
r |
GO:0005524 |
ATP binding |
BIOSIS:11600041556 |
IC: Inferred by Curator |
GO:0004088 |
F |
Or IDA? |
complete | |
|
FlyBase |
Drosophila |
r |
GO:0006541 |
glutamine metabolic process |
BIOSIS:11600041556 |
IC: Inferred by Curator |
GO:0004088 |
P |
Or IDA? What happens to glutamine in reaction is not measured. |
complete | |
|
EcoliWiki |
E. coli |
CarB |
GO:0005524 |
ATP binding |
IMP: Inferred from Mutant Phenotype |
F |
Compared carbamoyl phosphate synthetase activity for wild-type and mutants in ATP-binding domain. |
complete | |||
|
EcoliWiki |
E. coli |
CarB |
Contributes to |
GO:0004086 |
carbamoyl-phosphate synthase activity |
IDA: Inferred from Direct Assay |
F |
CarAB was assayed for glutamine-dependent carbamoyl phosphate synthetase activity in a coupled assay. |
complete | ||
|
EcoliWiki |
E. coli |
CarB |
GO:0005515 |
protein binding |
IDA: Inferred from Direct Assay |
F |
CarA (light subunit) and CarB (heavy subunit) were reversibly separated using gel filtration. |
complete | |||
|
EcoliWiki |
E. coli |
CarB |
GO:0004086 |
carbamoyl-phosphate synthase activity |
IDA: Inferred from Direct Assay |
F |
Purified CarB was assayed for carbamoyl phosphate synthetase activity and compared to the holoenzyme (consisting of CarA and CarB). |
complete | |||
|
EcoliWiki |
E. coli |
CarB |
GO:0046872 |
metal ion binding |
IDA: Inferred from Direct Assay |
F |
Carbamoyl phosphate synthetase activity was assayed in the absence (resulting in no activity) or presence of varying concentrations of divalent cations (Mg2+, Ca2+, Mg2+, Co2+, or Zn2+). |
complete | |||
|
EcoliWiki |
E. coli |
CarB |
GO:0000166 |
nucleotide binding |
IMP: Inferred from Mutant Phenotype |
F |
Carbamoyl phosphate synthetase activity of wild-type and mutant proteins was monitored in the presence of varying concentrations of ornithine, IMP and UMP. |
complete | |||
|
EcoliWiki |
E. coli |
CarB |
GO:0019856 |
pyrimidine base biosynthetic process |
IMP: Inferred from Mutant Phenotype |
P |
E. coli mutants were isolated that were auxotrophic for arginine and uracil and the mutations were shown to be located in the carB gene. |
complete | |||
|
EcoliWiki |
E. coli |
CarB |
GO:0008652 |
amino acid biosynthetic process |
IMP: Inferred from Mutant Phenotype |
P |
E. coli mutants were isolated that were auxotrophic for arginine and uracil and the mutations were shown to be located in the carB gene. |
complete | |||
|
EcoliWiki |
E. coli |
CarB |
GO:0004088 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
IGI: Inferred from Genetic Interaction |
EcoliWiki:carA |
F |
CarB mutants are unable to use ammonia or glutamine as the nitrogen donor for carbamoyl phosphate synthesis. |
complete | ||
|
MGI |
Mouse |
Cad |
GO:0005737 |
cytoplasm |
ISS: Inferred from Sequence or Structural Similarity |
C |
ISO mouse orthology to hamster Based more on the immunohistochem than the fractionation. |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0005634 |
nucleus |
ISS: Inferred from Sequence or Structural Similarity |
C |
ISO modification:MOD:00047; O-phospho-L-threonine|thr456 Phosphorylated form is nuclear |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0005524 |
ATP binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
ISO orthology to hamster |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0004070 |
aspartate carbamoyltransferase activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
ISO to hamster |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0004151 |
dihydroorotase activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
ISO hamster |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0004088 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
ISO hamster |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0004672 |
protein kinase activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
ISO hamster target:P08955|thr1037 |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0006207 |
'de novo' pyrimidine base biosynthetic process |
ISS: Inferred from Sequence or Structural Similarity |
P |
ISO to hamster |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0046777 |
protein amino acid autophosphorylation |
ISS: Inferred from Sequence or Structural Similarity |
P |
ISO hamster target:P08955|thr1037 |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0018107 |
peptidyl-threonine phosphorylation |
ISS: Inferred from Sequence or Structural Similarity |
P |
ISO hamster target:P08955|thr1037 |
complete | |||
|
RGD |
Rat |
Cad |
GO:0004070 |
aspartate carbamoyltransferase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
MGI |
Mouse |
Cad |
GO:0004070 |
aspartate carbamoyltransferase activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
ISO hamster |
complete | |||
|
RGD |
Rat |
Cad |
GO:0004088 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0004151 |
dihydroorotase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0042802 |
identical protein binding |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0043234 |
protein complex |
IDA: Inferred from Direct Assay |
C |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0005625 |
soluble fraction |
IDA: Inferred from Direct Assay |
C |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0017144 |
drug metabolic process |
IDA: Inferred from Direct Assay |
P |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0009790 |
embryonic development |
IDA: Inferred from Direct Assay |
P |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0007565 |
female pregnancy |
IDA: Inferred from Direct Assay |
P |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0031100 |
organ regeneration |
IDA: Inferred from Direct Assay |
P |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0014075 |
response to amine stimulus |
IEP: Inferred from Expression Pattern |
P |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0031000 |
response to caffeine |
IEP: Inferred from Expression Pattern |
P |
complete | ||||
|
RGD |
Rat |
Cad |
GO:0033574 |
response to testosterone stimulus |
IEP: Inferred from Expression Pattern |
P |
complete | ||||
|
MGI |
Mouse |
Cad |
GO:0002134 |
UTP binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
New term: UTP binding ISO to hamster Based on assays of UTP allosteric inhibition of phosphorylated and non-phosphorylated species. |
complete | |||
|
MGI |
Mouse |
Cad |
GO:0005829 |
cytosol |
ISS: Inferred from Sequence or Structural Similarity |
C |
orthology to hamster. included for completeness. Term as used by them is more of a "fraction" |
complete | |||
|
FlyBase |
Drosophila |
r |
GO:0004088 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
FlyBase |
Drosophila |
r |
GO:0043234 |
protein complex |
IDA: Inferred from Direct Assay |
C |
complete | ||||
|
FlyBase |
Drosophila |
r |
GO:0004151 |
dihydroorotase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
FlyBase |
Drosophila |
r |
GO:0004070 |
aspartate carbamoyltransferase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0019856 |
pyrimidine base biosynthetic process |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
FlyBase |
Drosophila |
r |
GO:0006207 |
'de novo' pyrimidine base biosynthetic process |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0046132 |
pyrimidine ribonucleoside biosynthetic process |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0009792 |
embryonic development ending in birth or egg hatching |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0009792 |
embryonic development ending in birth or egg hatching |
IGI: Inferred from Genetic Interaction |
WB:WBGene00004360 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0048562 |
embryonic organ morphogenesis |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0048562 |
embryonic organ morphogenesis |
IGI: Inferred from Genetic Interaction |
WB:WBGene00004360 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0035121 |
tail morphogenesis |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0040010 |
positive regulation of growth rate |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0018991 |
oviposition |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0050891 |
multicellular organismal water homeostasis |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0002119 |
nematode larval development |
IMP: Inferred from Mutant Phenotype |
P |
Based on an RNAi experiment not yet annotated in WB. |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0002119 |
nematode larval development |
IGI: Inferred from Genetic Interaction |
WB:WBGene00004360 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0060323 |
head morphogenesis |
IMP: Inferred from Mutant Phenotype |
P |
Based on an RNAi experiment not yet curated in WB. |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0030036 |
actin cytoskeleton organization |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0045104 |
intermediate filament cytoskeleton organization |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0015012 |
heparan sulfate proteoglycan biosynthetic process |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
complete | |||
|
WormBase |
C.elegans |
pyr-1 (WBGene00004259) |
GO:0050654 |
chondroitin sulfate proteoglycan metabolic process |
IMP: Inferred from Mutant Phenotype |
WB:cu8 |
P |
Chondroitin sulfate levels increase in pyr-1 mutant animals. |
complete | ||
|
DictyBase |
Dicty |
pyr1-3|DDB_G0276335 |
GO:0004088 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
DictyBase |
Dicty |
pyr1-3|DDB_G0276335 |
GO:0004070 |
aspartate carbamoyltransferase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
DictyBase |
Dicty |
pyr1-3|DDB_G0276335 |
GO:0004151 |
dihydroorotase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
|
DictyBase |
Dicty |
pyr1-3|DDB_G0276335 |
GO:0006541 |
glutamine metabolic process |
IDA: Inferred from Direct Assay |
P |
complete | ||||
|
EcoliWiki |
E. coli |
carA |
GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
complete | ||||
|
EcoliWiki |
E. coli |
carA |
GO:0005515 |
protein binding |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
|
EcoliWiki |
E. coli |
carA |
GO:0006541 |
glutamine metabolic process |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
|
EcoliWiki |
E. coli |
carA |
Contributes to |
GO:0004088 |
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
IMP: Inferred from Mutant Phenotype |
F |
complete | |||
|
EcoliWiki |
E. coli |
carA |
GO:0006207 |
'de novo' pyrimidine base biosynthetic process |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
|
EcoliWiki |
E. coli |
carA |
GO:0006526 |
arginine biosynthetic process |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
| edit table |
Notes
Minutes
E. coli: CPS2 function annotation two genes, carA and carB, and it's complex, both annotated
Yes, annotate all here and choose what's used for propagation.
London: a term describing allosteric regulation would be useful. Allosteric (mechanics) are outside of GO scope, only the regulation part is important
- Regulation discussion. What experiments needed to use regulation term?
- Poll:
Would you annotate to both 'regulation of process x' and also to 'process x' for a key protein in the pathway which has also been found to regulate the whole pathway by its allosteric binding site
- 67% yes, 11% NO, 22% Unsure
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Norby, S (1973) The biochemical genetics of rudimentary mutants of Drosophila melanogaster. I. Aspartate carbamoyltransferase levels in complementing and non-complementing strains. Hereditas 73 11-6 PubMed GONUTS page
- ↑ Lindsey-Boltz, LA et al. (2004) The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD. Nucleic Acids Res. 32 4524-30 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Sigoillot, FD et al. (2005) Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J. Biol. Chem. 280 25611-20 PubMed GONUTS page
- ↑ Angeletti, PC & Engler, JA (1998) Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix. J. Virol. 72 2896-904 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Sigoillot, FD et al. (2002) Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis. J. Biol. Chem. 277 24809-17 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 Coleman, PF et al. (1977) Purification from hamster cells of the multifunctional protein that initiates de novo synthesis of pyrimidine nucleotides. J. Biol. Chem. 252 6379-85 PubMed GONUTS page
- ↑ 7.0 7.1 Rawls, JM & Fristrom, JW (1975) A complex genetic locus that controls of the first three steps of pyrimidine biosynthesis in Drosophila. Nature 255 738-40 PubMed GONUTS page
- ↑ 8.0 8.1 Kothe, M & Powers-Lee, SG (2004) Nucleotide recognition in the ATP-grasp protein carbamoyl phosphate synthetase. Protein Sci. 13 466-75 PubMed GONUTS page
- ↑ Trotta, PP et al. (1974) Reversible dissociation of the monomer of glutamine-dependent carbamyl phosphate synthetase into catalytically active heavy and light subunits. J. Biol. Chem. 249 492-9 PubMed GONUTS page
- ↑ Rubino, SD et al. (1987) In vivo synthesis of carbamyl phosphate from NH3 by the large subunit of Escherichia coli carbamyl phosphate synthetase. J. Biol. Chem. 262 4382-6 PubMed GONUTS page
- ↑ Raushel, FM et al. (1979) Paramagnetic probes for carbamoyl-phosphate synthetase: metal ion binding studies and preparation of nitroxide spin-labeled derivatives. Biochemistry 18 5562-6 PubMed GONUTS page
- ↑ Fresquet, V et al. (2000) Site-directed mutagenesis of the regulatory domain of Escherichia coli carbamoyl phosphate synthetase identifies crucial residues for allosteric regulation and for transduction of the regulatory signals. J. Mol. Biol. 299 979-91 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Guillou, F et al. (1992) Mutational analysis of carbamyl phosphate synthetase. Substitution of Glu841 leads to loss of functional coupling between the two catalytic domains of the synthetase subunit. Biochemistry 31 1656-64 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Mori, M et al. (1975) Aggregation states and catalytic properties of the multienzyme complex catalyzing the initial steps of pyrimidine biosynthesis in rat liver. Biochemistry 14 2622-30 PubMed GONUTS page
- ↑ 15.0 15.1 Mori, M & Tatibana, M (1978) Multi-enzyme complex of glutamine-dependent carbamoyl-phosphate synthetase with aspartate carbamoyltransferase and dihydroorotase from rat ascites-hepatoma cells. Purification, molecular properties and limited proteolysis. Eur. J. Biochem. 86 381-8 PubMed GONUTS page
- ↑ Bond, JS (1976) Acid inactivation of short-lived rat liver enzymes. Biochim. Biophys. Acta 451 238-49 PubMed GONUTS page
- ↑ Schroeder, PE et al. (2008) The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites. Drug Metab. Dispos. 36 1780-5 PubMed GONUTS page
- ↑ NORDMANN, Y et al. (1964) ACTIVITY OF ASPARTATE TRANSCARBAMYLASE IN HEART AND LIVER OF THE DEVELOPING RAT. Nature 201 616-7 PubMed GONUTS page
- ↑ Thibodeau, PS & Thayer, SA (1967) Effect of pregnancy and hormones on the activity of aspartate transcarbamylase and the level of nucleic acids in the mammary gland of the rat. Endocrinology 80 505-9 PubMed GONUTS page
- ↑ CALVA, E & COHEN, PP (1959) Carbamyl phosphate-aspartate transcarbamylase activity in regenerating rat liver. Cancer Res. 19 679-83 PubMed GONUTS page
- ↑ Karsai, T et al. () Effect of dimethylnitrosamine upon carbamoyl phosphate and ornithine utilization in rat liver. Anticancer Res. 5 441-4 PubMed GONUTS page
- ↑ Miñana, MD et al. (1984) Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain. J. Neurochem. 43 1556-60 PubMed GONUTS page
- ↑ Görlich, M & Heise, E (1967) Activity of aspartate transcarbamylase in mammary tumours induced by 7,12-dimethyl-benzanthracene in the rat. Nature 213 934-5 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 Brothers, VM et al. (1978) Rudimentary locus of Drosophila melanogaster: partial purification of a carbamylphosphate synthase--aspartate transcarbamylase--dihydroorotase complex. Biochem. Genet. 16 321-32 PubMed GONUTS page
- ↑ 25.00 25.01 25.02 25.03 25.04 25.05 25.06 25.07 25.08 25.09 25.10 25.11 25.12 25.13 25.14 25.15 25.16 Franks, DM et al. (2006) C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans. Dev. Biol. 296 409-20 PubMed GONUTS page
- ↑ Norby, S (1970) A specific nutritional requirement for pyrimidines in rudimentary mutants of Drosophila melanogaster. Hereditas 66 205-14 PubMed GONUTS page
- ↑ 27.0 27.1 27.2 27.3 Wales, ME et al. (1989) Characterization of pyrimidine metabolism in the cellular slime mold, Dictyostelium discoideum. Can. J. Microbiol. 35 432-8 PubMed GONUTS page
- ↑ 28.0 28.1 Guillou, F et al. (1989) Escherichia coli carbamoyl-phosphate synthetase: domains of glutaminase and synthetase subunit interaction. Proc. Natl. Acad. Sci. U.S.A. 86 8304-8 PubMed GONUTS page
- ↑ 29.0 29.1 Mullins, LS et al. (1991) Alterations in the energetics of the carbamoyl phosphate synthetase reaction by site-directed modification of the essential sulfhydryl group. J. Biol. Chem. 266 8236-40 PubMed GONUTS page
- ↑ 30.0 30.1 Piérard, A & Wiame, JM (1964) Regulation and mutation affecting a glutamine dependent formation of carbamyl phosphate in Escherichia coli. Biochem. Biophys. Res. Commun. 15 76-81 PubMed GONUTS page
a
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i
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p
- GO:0018107 ! peptidyl-threonine phosphorylation
- GO:0040010 ! positive regulation of growth rate
- GO:0046777 ! protein autophosphorylation
- GO:0005515 ! protein binding
- GO:0043234 ! protein complex
- GO:0004672 ! protein kinase activity
- GO:0019856 ! pyrimidine nucleobase biosynthetic process
- GO:0046132 ! pyrimidine ribonucleoside biosynthetic process
r
