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MOUSE:UGDH

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ugdh
Protein Name(s) UDP-glucose 6-dehydrogenase

UDP-Glc dehydrogenase UDP-GlcDH UDPGDH

External Links
UniProt O70475
EMBL AF061017
BC006749
CCDS CCDS19308.1
RefSeq NP_033492.1
XP_006503925.1
UniGene Mm.344831
ProteinModelPortal O70475
SMR O70475
IntAct O70475
MINT MINT-1854432
PhosphoSite O70475
MaxQB O70475
PaxDb O70475
PRIDE O70475
Ensembl ENSMUST00000031103
GeneID 22235
KEGG mmu:22235
UCSC uc008xns.1
CTD 7358
MGI MGI:1306785
eggNOG COG1004
HOGENOM HOG000153773
HOVERGEN HBG003512
InParanoid O70475
KO K00012
OMA AEEGVNH
PhylomeDB O70475
TreeFam TF105671
Reactome REACT_230621
UniPathway UPA00038
ChiTaRS Ugdh
NextBio 302285
PRO PR:O70475
Proteomes UP000000589
Bgee O70475
CleanEx MM_UGDH
ExpressionAtlas O70475
Genevestigator O70475
GO GO:0005634
GO:0051287
GO:0003979
GO:0001702
GO:0006065
Gene3D 3.40.50.720
InterPro IPR008927
IPR016040
IPR017476
IPR014027
IPR014026
IPR001732
IPR028356
PANTHER PTHR11374
PTHR11374:SF3
Pfam PF00984
PF03720
PF03721
PIRSF PIRSF500133
PIRSF000124
SMART SM00984
SUPFAM SSF48179
SSF52413
TIGRFAMs TIGR03026

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0003979

UDP-glucose 6-dehydrogenase activity

PMID:9737970[1]

ECO:0000314

F

Fig. 4A shows expression of Ugdh in the developing mouse embryo which revealed a single Ugdh transcript of approximately 2.4 kb.

Based on Table II, spectrophotometric measurement indicated that Udpgdh activity of lysates prepared from transfection of a mouse Ugdh expression vector into COS-1 cells was elevated 5–12-fold in comparison to those prepared from vector only, mock-transfected, control cells

complete
CACAO 4498

involved_in

GO:0001702

gastrulation with mouth forming second

PMID:14505572[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030206

chondroitin sulfate biosynthetic process

PMID:14505572[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0015012

heparan sulfate proteoglycan biosynthetic process

PMID:14505572[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034214

protein hexamerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60701

P

Seeded From UniProt

complete

involved_in

GO:0006065

UDP-glucuronate biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60701

P

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

PMID:9737970[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006024

glycosaminoglycan biosynthetic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261445
PANTHER:PTN000146693
WB:WBGene00005022

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000146693
RGD:621879
TAIR:locus:2093827
TAIR:locus:2157275
TAIR:locus:2180872

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000146693
TAIR:locus:2093827
TAIR:locus:2157275
TAIR:locus:2180872

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034214

protein hexamerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60701

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006065

UDP-glucuronate biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60701

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621879

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60701

C

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60701

F

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621879

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001702

gastrulation with mouth forming second

PMID:15755804[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2678264

P

has_participant:(EMAPA:16039)

Seeded From UniProt

complete

involved_in

GO:0034214

protein hexamerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O60701
ensembl:ENSP00000319501

P

Seeded From UniProt

complete

involved_in

GO:0006065

UDP-glucuronate biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O60701
ensembl:ENSP00000319501

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O60701
ensembl:ENSP00000319501

C

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O60701
ensembl:ENSP00000319501

F

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028356

F

Seeded From UniProt

complete

enables

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001732
InterPro:IPR014026
InterPro:IPR014027
InterPro:IPR017476

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001732
InterPro:IPR014026
InterPro:IPR014027

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001732
InterPro:IPR008927
InterPro:IPR014026
InterPro:IPR014027
InterPro:IPR017476

P

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.22

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

involved_in

GO:0006065

UDP-glucuronate biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00038

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Spicer, AP et al. (1998) Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes. J. Biol. Chem. 273 25117-24 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 García-García, MJ & Anderson, KV (2003) Essential role of glycosaminoglycans in Fgf signaling during mouse gastrulation. Cell 114 727-37 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page
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