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HUMAN:UGDH

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UGDH
Protein Name(s) UDP-glucose 6-dehydrogenase

UDP-Glc dehydrogenase UDP-GlcDH UDPGDH

External Links
UniProt O60701
EMBL AF061016
AJ007702
AJ272274
AJ272275
AJ272276
AJ272277
AJ272278
AJ272279
AJ272280
AJ272281
AK097930
AK297737
AC021148
CH471069
BC022781
AF049126
CCDS CCDS3455.1
CCDS54757.1
CCDS54758.1
PIR JE0353
RefSeq NP_001171629.1
NP_001171630.1
NP_003350.1
XP_006714092.1
UniGene Hs.572518
PDB 2Q3E
2QG4
3ITK
3KHU
3PRJ
3PTZ
3TDK
3TF5
4EDF
4QEJ
PDBsum 2Q3E
2QG4
3ITK
3KHU
3PRJ
3PTZ
3TDK
3TF5
4EDF
4QEJ
ProteinModelPortal O60701
SMR O60701
BioGrid 113205
IntAct O60701
MINT MINT-5000810
STRING 9606.ENSP00000319501
PhosphoSite O60701
REPRODUCTION-2DPAGE O60701
MaxQB O60701
PaxDb O60701
PeptideAtlas O60701
PRIDE O60701
DNASU 7358
Ensembl ENST00000316423
ENST00000501493
ENST00000506179
ENST00000507089
GeneID 7358
KEGG hsa:7358
UCSC uc003guk.2
uc003gul.2
CTD 7358
GeneCards GC04M039502
HGNC HGNC:12525
HPA CAB034444
HPA036656
HPA036657
MIM 603370
neXtProt NX_O60701
PharmGKB PA37170
eggNOG COG1004
GeneTree ENSGT00390000015355
HOGENOM HOG000153773
HOVERGEN HBG003512
InParanoid O60701
KO K00012
OMA VIIMNDY
OrthoDB EOG7034GP
PhylomeDB O60701
TreeFam TF105671
Reactome REACT_6737
SABIO-RK O60701
UniPathway UPA00038
ChiTaRS UGDH
EvolutionaryTrace O60701
GeneWiki UGDH
GenomeRNAi 7358
NextBio 28812
PRO PR:O60701
Proteomes UP000005640
Bgee O60701
CleanEx HS_UGDH
ExpressionAtlas O60701
Genevestigator O60701
GO GO:0005829
GO:0070062
GO:0005634
GO:0009055
GO:0051287
GO:0003979
GO:0052695
GO:0001702
GO:0006024
GO:0044281
GO:0006011
GO:0006065
GO:0006805
Gene3D 3.40.50.720
InterPro IPR008927
IPR016040
IPR017476
IPR014027
IPR014026
IPR001732
IPR028356
PANTHER PTHR11374
PTHR11374:SF3
Pfam PF00984
PF03720
PF03721
PIRSF PIRSF500133
PIRSF000124
SMART SM00984
SUPFAM SSF48179
SSF52413
TIGRFAMs TIGR03026

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0030206

chondroitin sulfate biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O70475

P

Seeded From UniProt

complete

involved_in

GO:0015012

heparan sulfate proteoglycan biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O70475

P

Seeded From UniProt

complete

involved_in

GO:0001702

gastrulation with mouth forming second

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O70475

P

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

PMID:27966912[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006065

UDP-glucuronate biosynthetic process

PMID:27966912[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034214

protein hexamerization

PMID:27966912[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006024

glycosaminoglycan biosynthetic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261445
PANTHER:PTN000146693
WB:WBGene00005022

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000146693
RGD:621879
TAIR:locus:2093827
TAIR:locus:2157275
TAIR:locus:2180872

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000146693
TAIR:locus:2093827
TAIR:locus:2157275
TAIR:locus:2180872

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030206

chondroitin sulfate biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70475
ensembl:ENSMUSP00000031103

P

Seeded From UniProt

complete

involved_in

GO:0015012

heparan sulfate proteoglycan biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70475
ensembl:ENSMUSP00000031103

P

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70475
ensembl:ENSMUSP00000031103

F

Seeded From UniProt

complete

involved_in

GO:0001702

gastrulation with mouth forming second

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70475
ensembl:ENSMUSP00000031103

P

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028356

F

Seeded From UniProt

complete

enables

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001732
InterPro:IPR014026
InterPro:IPR014027
InterPro:IPR017476

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001732
InterPro:IPR014026
InterPro:IPR014027

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001732
InterPro:IPR008927
InterPro:IPR014026
InterPro:IPR014027
InterPro:IPR017476

P

Seeded From UniProt

complete

enables

GO:0003979

UDP-glucose 6-dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.22

F

Seeded From UniProt

complete

involved_in

GO:0006065

UDP-glucuronate biosynthetic process

Reactome:R-HSA-173599

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-173597

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

P

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

involved_in

GO:0006065

UDP-glucuronate biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00038

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Beattie, NR et al. (2017) Allostery and Hysteresis Are Coupled in Human UDP-Glucose Dehydrogenase. Biochemistry 56 202-211 PubMed GONUTS page
  2. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page