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Category:GO:0007174 ! epidermal growth factor catabolic process
name: epidermal growth factor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor." [GOC:bf, GOC:signaling, PMID:2985587]
comment: This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'.
synonym: "EGF breakdown" EXACT [GOC:bf]
synonym: "EGF catabolism" EXACT [GOC:bf]
synonym: "EGF receptor ligand processing" RELATED [GOC:bf]
synonym: "epidermal growth factor breakdown" EXACT [GOC:bf]
synonym: "epidermal growth factor catabolism" EXACT [GOC:bf]
synonym: "epidermal growth factor ligand processing" RELATED [GOC:bf]
synonym: "intracellular EGF processing" RELATED [PMID:2985587]
synonym: "receptor-mediated EGF processing" RELATED [PMID:1683723]
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway
AmiGO
<GOterm>GO:0007174</GOterm>
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