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HUMAN:SNX5
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SNX5 | |
| Protein Name(s) | Sorting nexin-5 | |
| External Links | ||
| UniProt | Q9Y5X3 | |
| EMBL | AF121855 BT007191 AK001793 AK123903 AL121585 BC000100 CH471133 CH471133 CH471133 CH471133 BC093623 BC093980 BC143274 | |
| CCDS | CCDS13130.1 | |
| RefSeq | NP_055241.1 NP_689413.1 | |
| UniGene | Hs.316890 | |
| PDB | 1SYS | |
| PDBsum | 1SYS | |
| ProteinModelPortal | Q9Y5X3 | |
| SMR | Q9Y5X3 | |
| BioGrid | 118022 | |
| IntAct | Q9Y5X3 | |
| MINT | MINT-2823978 | |
| STRING | 9606.ENSP00000366988 | |
| iPTMnet | Q9Y5X3 | |
| PhosphoSitePlus | Q9Y5X3 | |
| DMDM | 10720289 | |
| EPD | Q9Y5X3 | |
| PaxDb | Q9Y5X3 | |
| PeptideAtlas | Q9Y5X3 | |
| PRIDE | Q9Y5X3 | |
| DNASU | 27131 | |
| Ensembl | ENST00000377759 ENST00000377768 ENST00000606557 | |
| GeneID | 27131 | |
| KEGG | hsa:27131 | |
| UCSC | uc002wqc.5 | |
| CTD | 27131 | |
| DisGeNET | 27131 | |
| GeneCards | SNX5 | |
| HGNC | HGNC:14969 | |
| HPA | CAB020679 HPA051187 | |
| MIM | 605937 | |
| neXtProt | NX_Q9Y5X3 | |
| OpenTargets | ENSG00000089006 | |
| PharmGKB | PA37945 | |
| eggNOG | KOG1660 ENOG410XPZY | |
| GeneTree | ENSGT00870000136451 | |
| HOVERGEN | HBG000716 | |
| InParanoid | Q9Y5X3 | |
| KO | K17920 | |
| OMA | HEDFIWL | |
| OrthoDB | EOG090B0791 | |
| PhylomeDB | Q9Y5X3 | |
| TreeFam | TF313698 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-432722 R-HSA-432722] | |
| ChiTaRS | SNX5 | |
| EvolutionaryTrace | Q9Y5X3 | |
| GeneWiki | SNX5 | |
| GenomeRNAi | 27131 | |
| PRO | PR:Q9Y5X3 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000089006 | |
| CleanEx | HS_SNX5 | |
| ExpressionAtlas | Q9Y5X3 | |
| Genevisible | Q9Y5X3 | |
| GO | GO:0005913 GO:0030659 GO:0005829 GO:0031901 GO:0031234 GO:0031313 GO:0070685 GO:0001891 GO:0030904 GO:0030905 GO:0001726 GO:0097422 GO:0098641 GO:0034452 GO:0035091 GO:0046982 GO:0006886 GO:0006907 GO:0016241 GO:0042147 GO:0016050 | |
| Gene3D | 3.30.1520.10 | |
| InterPro | IPR001683 IPR028654 IPR014637 IPR015404 | |
| PANTHER | PTHR10555:SF165 | |
| Pfam | PF00787 PF09325 | |
| PIRSF | PIRSF036924 | |
| SUPFAM | SSF64268 | |
| PROSITE | PS50195 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
Colocalizes with |
GO:0005899 |
insulin receptor complex |
ECO:0000314 |
C |
Figure 1C: In human renal proximal tubule cells, SNX5 colocalized with the IR at the basal state and increasingly after administration of insulin. |
complete | ||||
| GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
C |
Figure 1C: In human renal proximal tubule cells, SNX5 colocalized with the insulin receptor in the perinuclear area |
complete | |||||
| GO:0046628 |
positive regulation of insulin receptor signaling pathway |
ECO:0000315 |
P |
Figure 3A: Ratio of phosphorylated to dephosphorylated IRS1, an adaptor protein which initiates downstream insulin signaling activity, was decreased in basal-state human renal proximal tubule cells with SNX5 expression knocked down. Figure 3D: After addition of insulin, phosphorylated PKB, a downstream effector of insulin signaling, was increased to a lesser extent in human renal proximal tubule cells with SNX5 expression knocked down as compared to mock control. |
complete | |||||
| GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
P |
Figure 2D, 2E: insulin receptor mRNA expression is decreased in human renal proximal tubule cells with SNX5 expression knocked down. |
complete | |||||
|
involved_in |
GO:0016241 |
regulation of macroautophagy |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045296 |
cadherin binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042147 |
retrograde transport, endosome to Golgi |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030905 |
retromer, tubulation complex |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034452 |
dynactin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097422 |
tubular endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042147 |
retrograde transport, endosome to Golgi |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030904 |
retromer complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070685 |
macropinocytic cup |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0031901 |
early endosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031313 |
extrinsic component of endosome membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031234 |
extrinsic component of cytoplasmic side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031234 |
extrinsic component of cytoplasmic side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006907 |
pinocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0080025 |
phosphatidylinositol-3,5-bisphosphate binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045776 |
negative regulation of blood pressure |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035815 |
positive regulation of renal sodium excretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031748 |
D1 dopamine receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0010314 |
phosphatidylinositol-5-phosphate binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007174 |
epidermal growth factor catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005903 |
brush border |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005768 |
endosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:B1H267 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006886 |
intracellular protein transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006907 |
pinocytosis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031901 |
early endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005769 |
early endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001891 |
phagocytic cup |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001726 |
ruffle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030659 |
cytoplasmic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Li, F et al. (2015) Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells. Endocrinology 156 2211-21 PubMed GONUTS page
- ↑ Maruzs, T et al. (2015) Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila. Traffic 16 1088-107 PubMed GONUTS page
- ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Trousdale, C & Kim, K (2015) Retromer: Structure, function, and roles in mammalian disease. Eur. J. Cell Biol. 94 513-21 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Wassmer, T et al. (2009) The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev. Cell 17 110-22 PubMed GONUTS page
- ↑ Wassmer, T et al. (2007) A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. J. Cell. Sci. 120 45-54 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Lim, JP et al. (2008) A role for SNX5 in the regulation of macropinocytosis. BMC Cell Biol. 9 58 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Merino-Trigo, A et al. (2004) Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation. J. Cell. Sci. 117 6413-24 PubMed GONUTS page
c
e
- GO:0005769 ! early endosome
- GO:0031901 ! early endosome membrane
- GO:0006897 ! endocytosis
- GO:0005768 ! endosome
- GO:0007174 ! epidermal growth factor catabolic process
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane
- GO:0031313 ! extrinsic component of endosome membrane
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0001891 ! phagocytic cup
- GO:0035091 ! phosphatidylinositol binding
- GO:0080025 ! phosphatidylinositol-3,5-bisphosphate binding
- GO:0070273 ! phosphatidylinositol-4-phosphate binding
- GO:0010314 ! phosphatidylinositol-5-phosphate binding
- GO:0006907 ! pinocytosis
- GO:0005886 ! plasma membrane
- GO:0035815 ! positive regulation of renal sodium excretion
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0046628 ! positive regulation of insulin receptor signaling pathway
- Primates
- GO:0046982 ! protein heterodimerization activity
- GO:0015031 ! protein transport
r
