RAT:SNX5

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Snx5
Protein Name(s)	Sorting nexin-5
External Links
UniProt	B1H267
EMBL	BC160883
RefSeq	XP_006235181.1
UniGene	Rn.86151
PDB	3HPB 3HPC
PDBsum	3HPB 3HPC
ProteinModelPortal	B1H267
SMR	B1H267
STRING	10116.ENSRNOP00000008934
PaxDb	B1H267
PeptideAtlas	B1H267
PRIDE	B1H267
Ensembl	ENSRNOT00000008934 ENSRNOT00000074606
GeneID	296199
UCSC	RGD:1310190
CTD	27131
RGD	1310190
eggNOG	KOG1660 ENOG410XPZY
GeneTree	ENSGT00870000136451
HOGENOM	HOG000231691
HOVERGEN	HBG000716
InParanoid	B1H267
OMA	HEDFIWL
OrthoDB	EOG090B0791
PhylomeDB	B1H267
TreeFam	TF313698
Reactome	[www.reactome.org/content/detail/R-RNO-432722 R-RNO-432722]
EvolutionaryTrace	B1H267
PRO	PR:B1H267
Proteomes	UP000002494
Bgee	ENSRNOG00000006077
ExpressionAtlas	B1H267
Genevisible	B1H267
GO	GO:0005913 GO:0030659 GO:0005829 GO:0031901 GO:0005768 GO:0031234 GO:0031313 GO:0019898 GO:0070685 GO:0001891 GO:0030904 GO:0001726 GO:0097422 GO:0034452 GO:0035091 GO:0098609 GO:0006897 GO:0006886 GO:0006907 GO:0042147 GO:0016050
Gene3D	3.30.1520.10
InterPro	IPR001683 IPR028654 IPR014637 IPR015404
PANTHER	PTHR10555:SF165
Pfam	PF00787 PF09325
PIRSF	PIRSF036924
SUPFAM	SSF64268
PROSITE	PS50195

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
Colocalizes with	GO:0005903	brush border	PMID:25825816^[1]	ECO:0000314			C	Figure 1B: SNX5 colocalizes at the brush border of renal proximal tubule cells in rat kidney.	complete CACAO 12281
part_of	GO:0097422	tubular endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y5X3	C	Seeded From UniProt	complete
part_of	GO:0030904	retromer complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y5X3	C	Seeded From UniProt	complete
enables	GO:0034452	dynactin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y5X3	F	Seeded From UniProt	complete
part_of	GO:0070685	macropinocytic cup	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y5X3	C	Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	PMID:19553671^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
colocalizes_with	GO:0031901	early endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y5X3	C	Seeded From UniProt	complete
part_of	GO:0031313	extrinsic component of endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y5X3	C	Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y5X3	C	Seeded From UniProt	complete
involved_in	GO:0006907	pinocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y5X3	P	Seeded From UniProt	complete
enables	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	PMID:16487940^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070273	phosphatidylinositol-4-phosphate binding	PMID:16487940^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:23195037^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035815	positive regulation of renal sodium excretion	PMID:23195037^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	PMID:23195037^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0010314	phosphatidylinositol-5-phosphate binding	PMID:16487940^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007174	epidermal growth factor catabolic process	PMID:16487940^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005903	brush border	PMID:23195037^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16487940^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16487940^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:16487940^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23195037^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0097422	tubular endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	C	Seeded From UniProt	complete
part_of	GO:0070685	macropinocytic cup	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	C	Seeded From UniProt	complete
involved_in	GO:0042147	retrograde transport, endosome to Golgi	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	P	Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	F	Seeded From UniProt	complete
enables	GO:0034452	dynactin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	F	Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	C	Seeded From UniProt	complete
part_of	GO:0031313	extrinsic component of endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	C	Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	C	Seeded From UniProt	complete
part_of	GO:0030904	retromer complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	C	Seeded From UniProt	complete
involved_in	GO:0006907	pinocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y5X3 ensembl:ENSP00000366998	P	Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028654	P	Seeded From UniProt	complete
involved_in	GO:0006907	pinocytosis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028654	P	Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001683 InterPro:IPR028654 InterPro:IPR036871	F	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0001726	ruffle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0300	C	Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C	Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0473	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Li, F et al. (2015) Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells. Endocrinology 156 2211-21 PubMed GONUTS page
↑ Koharudin, LM et al. (2009) The phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). J. Biol. Chem. 284 23697-707 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Liu, H et al. (2006) Inhibitory regulation of EGF receptor degradation by sorting nexin 5. Biochem. Biophys. Res. Commun. 342 537-46 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Villar, VA et al. (2013) Novel role of sorting nexin 5 in renal D(1) dopamine receptor trafficking and function: implications for hypertension. FASEB J. 27 1808-19 PubMed GONUTS page

[PMID:25825816-1] Li, F et al. (2015) Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells. Endocrinology 156 2211-21 PubMed GONUTS page

[PMID:19553671-2] Koharudin, LM et al. (2009) The phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). J. Biol. Chem. 284 23697-707 PubMed GONUTS page

[PMID:16487940-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Liu, H et al. (2006) Inhibitory regulation of EGF receptor degradation by sorting nexin 5. Biochem. Biophys. Res. Commun. 342 537-46 PubMed GONUTS page

[PMID:23195037-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Villar, VA et al. (2013) Novel role of sorting nexin 5 in renal D(1) dopamine receptor trafficking and function: implications for hypertension. FASEB J. 27 1808-19 PubMed GONUTS page

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RAT:SNX5

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