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Category:GO:0005242 ! inward rectifier potassium channel activity
name: inward rectifier potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]
synonym: "Kir channel activity" EXACT [GOC:cb]
is_a: GO:0005249 ! voltage-gated potassium channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity
AmiGO
<GOterm>GO:0005242</GOterm>
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