CHICK:O42229

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	IRK1 (ECO:0000313 with EMBL:AAB88799.1) (synonyms: KCNJ2 (ECO:0000313 with Ensembl:ENSGALP00000006967))
Protein Name(s)	Inward rectifier potassium channel (ECO:0000313 with EMBL:AAB88799.1) Inward rectifier potassium channel 2 (ECO:0000313 with Ensembl:ENSGALP00000006967)
External Links
UniProt	O42229
EMBL	AADN03007462 AF021141
UniGene	Gga.254
SMR	O42229
STRING	9031.ENSGALP00000006967
Ensembl	ENSGALT00000006978
GeneTree	ENSGT00760000118842
HOVERGEN	HBG006178
OMA	HNATVAM
OrthoDB	EOG7XPZ5K
TreeFam	TF313676
Reactome	REACT_103079 REACT_108526 REACT_197136
PRO	PR:O42229
Proteomes	UP000000539
GO	GO:0008076 GO:0005242 GO:0005546 GO:0086008 GO:0086002 GO:0015693 GO:0010107 GO:0051289 GO:0086091 GO:0060306 GO:0014861 GO:0055119 GO:0090076
Gene3D	2.60.40.1400
InterPro	IPR014756 IPR016449 IPR003271 IPR013518 IPR013673
PANTHER	PTHR11767
Pfam	PF01007 PF08466
PIRSF	PIRSF005465
PRINTS	PR01324 PR01320
SUPFAM	SSF81296

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1990573	potassium ion import across plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107501 PANTHER:PTN000205946 RGD:2960 RGD:61822 UniProtKB:P63252	P	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1194504 PANTHER:PTN000205946 RGD:2957 RGD:621662 RGD:628872 UniProtKB:A0A0B4KH86 UniProtKB:A0A0B4LHI9 UniProtKB:B7U540 UniProtKB:E7FD27 UniProtKB:F1NHE9 UniProtKB:P48544 UniProtKB:P48549 UniProtKB:P63252 UniProtKB:Q14500 WB:WBGene00002149 ZFIN:ZDB-GENE-031118-55 ZFIN:ZDB-GENE-131126-14	F	Seeded From UniProt	complete
involved_in	GO:0086001	cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35561 ensembl:ENSMUSP00000037192	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35561 ensembl:ENSMUSP00000037192	F	Seeded From UniProt	complete
involved_in	GO:0015693	magnesium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35561 ensembl:ENSMUSP00000037192	P	Seeded From UniProt	complete
involved_in	GO:1990573	potassium ion import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0090076	relaxation of skeletal muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0086013	membrane repolarization during cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0086011	membrane repolarization during action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
enables	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	F	Seeded From UniProt	complete
involved_in	GO:0086002	cardiac muscle cell action potential involved in contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0060306	regulation of membrane repolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0055119	relaxation of cardiac muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
part_of	GO:0031224	intrinsic component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	C	Seeded From UniProt	complete
involved_in	GO:0014861	regulation of skeletal muscle contraction via regulation of action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	C	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	F	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	F	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003271 InterPro:IPR016449	F	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003271 InterPro:IPR016449	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003271	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016449	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0633	P	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:O42229

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