RAT:IRK2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Kcnj2 (synonyms: Irk1)
Protein Name(s)	Inward rectifier potassium channel 2 Inward rectifier K(+) channel Kir2.1 IRK-1 RBL-IRK1 Potassium channel, inwardly rectifying subfamily J member 2
External Links
UniProt	Q64273
EMBL	L48490 AF021137
RefSeq	NP_058992.1 XP_006247629.1
UniGene	Rn.44415
ProteinModelPortal	Q64273
SMR	Q64273
DIP	DIP-33299N
IntAct	Q64273
STRING	10116.ENSRNOP00000006254
PaxDb	Q64273
Ensembl	ENSRNOT00000006254
GeneID	29712
KEGG	rno:29712
CTD	3759
RGD	61968
eggNOG	NOG72812
GeneTree	ENSGT00650000093228
HOGENOM	HOG000237325
HOVERGEN	HBG006178
InParanoid	Q64273
KO	K04996
OMA	HNATVAM
OrthoDB	EOG7XPZ5K
PhylomeDB	Q64273
TreeFam	TF313676
NextBio	610149
PRO	PR:Q64273
Genevestigator	Q64273
GO	GO:0030425 GO:0043197 GO:0005794 GO:0014704 GO:0031224 GO:0043025 GO:0005886 GO:0005791 GO:0005790 GO:0030315 GO:0008076 GO:0005242 GO:0005546 GO:0086008 GO:0086002 GO:0071260 GO:0015693 GO:1901381 GO:0010107 GO:0006813 GO:0051289 GO:0086004 GO:0086091 GO:0060306 GO:0014861 GO:0055119 GO:0090076
Gene3D	2.60.40.1400
InterPro	IPR014756 IPR016449 IPR003271 IPR013518 IPR013673
PANTHER	PTHR11767 PTHR11767:SF15
Pfam	PF01007 PF08466
PIRSF	PIRSF005465
PRINTS	PR01324 PR01320
SUPFAM	SSF81296

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63252	P	Seeded From UniProt	complete
part_of	GO:0031224	intrinsic component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63252	C	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63252	P	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63252	F	Seeded From UniProt	complete
involved_in	GO:1901381	positive regulation of potassium ion transmembrane transport	PMID:22426100^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086004	regulation of cardiac muscle cell contraction	PMID:22426100^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:17293496^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:18076085^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:12591157^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:12591157^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	PMID:23640888^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:23640888^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18076085^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:18076085^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	PMID:18076085^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	PMID:18076085^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1990573	potassium ion import across plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107501 PANTHER:PTN000205946 RGD:2960 RGD:61822 UniProtKB:P63252	P	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1194504 PANTHER:PTN000205946 RGD:2957 RGD:621662 RGD:628872 UniProtKB:A0A0B4KH86 UniProtKB:A0A0B4LHI9 UniProtKB:B7U540 UniProtKB:E7FD27 UniProtKB:F1NHE9 UniProtKB:P48544 UniProtKB:P48549 UniProtKB:P63252 UniProtKB:Q14500 WB:WBGene00002149 ZFIN:ZDB-GENE-031118-55 ZFIN:ZDB-GENE-131126-14	F	Seeded From UniProt	complete
involved_in	GO:0086001	cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35561 ensembl:ENSMUSP00000037192	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35561 ensembl:ENSMUSP00000037192	F	Seeded From UniProt	complete
involved_in	GO:0015693	magnesium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35561 ensembl:ENSMUSP00000037192	P	Seeded From UniProt	complete
involved_in	GO:1990573	potassium ion import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0090076	relaxation of skeletal muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0086013	membrane repolarization during cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0086011	membrane repolarization during action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
enables	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	F	Seeded From UniProt	complete
involved_in	GO:0086002	cardiac muscle cell action potential involved in contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0060306	regulation of membrane repolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0055119	relaxation of cardiac muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
part_of	GO:0031224	intrinsic component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	C	Seeded From UniProt	complete
involved_in	GO:0014861	regulation of skeletal muscle contraction via regulation of action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	C	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	P	Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	F	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63252 ensembl:ENSP00000243457	F	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003271 InterPro:IPR016449	F	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003271 InterPro:IPR016449	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003271	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016449	C	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0633	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hu, B et al. (2012) Experimental study on inhibition of rat ventricular Ik1 by RNA interference targeting the KCNJ2 gene. Biosci Trends 6 26-32 PubMed GONUTS page
↑ Saygili, E et al. (2007) Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes. Am. J. Physiol. Heart Circ. Physiol. 292 H2898-905 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Howe, MW et al. (2008) Cellular and subcellular localization of Kir2.1 subunits in neurons and glia in piriform cortex with implications for K+ spatial buffering. J. Comp. Neurol. 506 877-93 PubMed GONUTS page
↑ ^4.0 ^4.1 Prüss, H et al. (2003) Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Brain Res. Mol. Brain Res. 110 203-19 PubMed GONUTS page
↑ ^5.0 ^5.1 Vaidyanathan, R et al. (2013) The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9). J. Biol. Chem. 288 17472-80 PubMed GONUTS page
↑ ^6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22426100-1] 1.0 ^1.1 Hu, B et al. (2012) Experimental study on inhibition of rat ventricular Ik1 by RNA interference targeting the KCNJ2 gene. Biosci Trends 6 26-32 PubMed GONUTS page

[PMID:17293496-2] Saygili, E et al. (2007) Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes. Am. J. Physiol. Heart Circ. Physiol. 292 H2898-905 PubMed GONUTS page

[PMID:18076085-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Howe, MW et al. (2008) Cellular and subcellular localization of Kir2.1 subunits in neurons and glia in piriform cortex with implications for K+ spatial buffering. J. Comp. Neurol. 506 877-93 PubMed GONUTS page

[PMID:12591157-4] 4.0 ^4.1 Prüss, H et al. (2003) Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Brain Res. Mol. Brain Res. 110 203-19 PubMed GONUTS page

[PMID:23640888-5] 5.0 ^5.1 Vaidyanathan, R et al. (2013) The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9). J. Biol. Chem. 288 17472-80 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:IRK2

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