HUMAN:KCNH2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KCNH2 (synonyms: ERG, ERG1, HERG)
Protein Name(s)	Potassium voltage-gated channel subfamily H member 2 Eag homolog Ether-a-go-go-related gene potassium channel 1 ERG-1 Eag-related protein 1 Ether-a-go-go-related protein 1 H-ERG hERG-1 hERG1 Voltage-gated potassium channel subunit Kv11.1
External Links
UniProt	Q12809
EMBL	U04270 AB009071 AB044806 AF363636 AJ512214 AJ609614 FJ938021 DQ784808 AC006343 AC011234 CH471173 AJ010538 AJ010539 AJ010540 AJ010541 AJ010542 AJ010543 AJ010544 AJ010545 AJ010546 AJ010547 AJ010548 AJ010549 AJ010550 AJ010551 CH471173 BC001914 BC004311 AF052728
CCDS	CCDS5910.1 CCDS5911.1
PIR	I38465
RefSeq	NP_000229.1 NP_001191727.1 NP_742053.1 NP_742054.1
UniGene	Hs.647099
PDB	1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 4HP9 4HQA
PDBsum	1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 4HP9 4HQA
ProteinModelPortal	Q12809
SMR	Q12809
BioGrid	109959
DIP	DIP-48929N
IntAct	Q12809
MINT	MINT-1427435
STRING	9606.ENSP00000262186
BindingDB	Q12809
ChEMBL	CHEMBL2362996
DrugBank	DB00346 DB01118 DB00276 DB00637 DB01136 DB00477 DB00604 DB00204 DB00590 DB01142 DB04855 DB01218 DB00308 DB00458 DB01110 DB01100 DB00457 DB01182 DB00908 DB06144 DB00489 DB01162 DB00679 DB00661
GuidetoPHARMACOLOGY	572
TCDB	1.A.1.20.1
PhosphoSite	Q12809
DMDM	7531135
PaxDb	Q12809
PRIDE	Q12809
DNASU	3757
Ensembl	ENST00000262186 ENST00000330883
GeneID	3757
KEGG	hsa:3757
UCSC	uc003wib.3 uc003wic.3
CTD	3757
GeneCards	GC07M150642
GeneReviews	KCNH2
HGNC	HGNC:6251
HPA	CAB006838
MIM	152427 609620 613688
neXtProt	NX_Q12809
Orphanet	51083 101016
PharmGKB	PA212
eggNOG	COG2202
GeneTree	ENSGT00760000118772
HOVERGEN	HBG052232
InParanoid	Q12809
KO	K04905
OMA	DEVPAMD
OrthoDB	EOG75B879
PhylomeDB	Q12809
TreeFam	TF313130
Reactome	REACT_75770
SignaLink	Q12809
ChiTaRS	KCNH2
EvolutionaryTrace	Q12809
GeneWiki	HERG
GenomeRNAi	3757
NextBio	14717
PRO	PR:Q12809
Proteomes	UP000005640
Bgee	Q12809
CleanEx	HS_ERG HS_KCNH2
ExpressionAtlas	Q12809
Genevestigator	Q12809
GO	GO:0009986 GO:0005737 GO:0005635 GO:0005886 GO:0008076 GO:0005251 GO:0042802 GO:0005242 GO:0000155 GO:0042803 GO:0031625 GO:0005249 GO:1902282 GO:0060048 GO:0035690 GO:0086010 GO:0086011 GO:0086013 GO:1902303 GO:1901380 GO:1901381 GO:0071435 GO:0055075 GO:0071805 GO:0086091 GO:0003064 GO:0042391 GO:0060306 GO:1901379 GO:0060307 GO:0007268 GO:0086005
Gene3D	2.60.120.10
InterPro	IPR018490 IPR000595 IPR005821 IPR003938 IPR003967 IPR030172 IPR001610 IPR000014 IPR000700 IPR014710
PANTHER	PTHR10217:SF468
Pfam	PF00027 PF00520 PF13426
PRINTS	PR01463 PR01470
SMART	SM00100 SM00086 SM00091
SUPFAM	SSF51206 SSF55785
TIGRFAMs	TIGR00229
PROSITE	PS50042 PS50113 PS50112

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1990573	potassium ion import across plasma membrane	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:28280240^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:1902937	inward rectifier potassium channel complex	PMID:14525949^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	PMID:14525949^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0086009	membrane repolarization	PMID:14525949^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	PMID:21536673^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:25281747^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:25281747^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	PMID:25281747^[5]	ECO:0000305	curator inference used in manual assertion	GO:0005251	F	Seeded From UniProt	complete
involved_in	GO:0097623	potassium ion export across plasma membrane	PMID:25281747^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q6ZRF8	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25281747^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0055131	C3HC4-type RING finger domain binding	PMID:25281747^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6ZRF8	F	Seeded From UniProt	complete
enables	GO:0005251	delayed rectifier potassium channel activity	PMID:25281747^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q6ZRF8	F	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:18923542^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q03135	F	Seeded From UniProt	complete
involved_in	GO:1903765	negative regulation of potassium ion export across plasma membrane	PMID:8587608^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903765	negative regulation of potassium ion export across plasma membrane	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	PMID:21536673^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1901381	positive regulation of potassium ion transmembrane transport	PMID:7736582^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901380	negative regulation of potassium ion transmembrane transport	PMID:8587608^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901380	negative regulation of potassium ion transmembrane transport	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901379	regulation of potassium ion transmembrane transport	PMID:11953308^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:21536673^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086013	membrane repolarization during cardiac muscle cell action potential	PMID:21536673^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086011	membrane repolarization during action potential	PMID:7736582^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086011	membrane repolarization during action potential	PMID:21463633^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086011	membrane repolarization during action potential	PMID:11953308^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086010	membrane depolarization during action potential	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086005	ventricular cardiac muscle cell action potential	PMID:21536673^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:21063088^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:7736582^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:8587608^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:11953308^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097623	potassium ion export across plasma membrane	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	PMID:21536673^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060306	regulation of membrane repolarization	PMID:7736582^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060306	regulation of membrane repolarization	PMID:21463633^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:21536673^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055075	potassium ion homeostasis	PMID:8587608^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055075	potassium ion homeostasis	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8995352^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12809	F	Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:8587608^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21463633^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21463633^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96PU5	F	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21536673^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:7736582^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:8587608^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21463633^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005251	delayed rectifier potassium channel activity	PMID:7736582^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:21063088^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:11953308^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	PMID:8587608^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005242	inward rectifier potassium channel activity	PMID:7604285^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341721 MGI:MGI:1341722 PANTHER:PTN000025350 RGD:68398 UniProtKB:O18965 UniProtKB:O95259 UniProtKB:Q12809	P	Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341722 PANTHER:PTN000025350 RGD:621414 UniProtKB:Q12809	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341721 PANTHER:PTN000025350 RGD:620304 RGD:621414 RGD:68398 UniProtKB:O18965 UniProtKB:O95259 ZFIN:ZDB-GENE-070912-23	C	Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000535 MGI:MGI:1341722 PANTHER:PTN000025350 RGD:2549 RGD:620304 RGD:621112 RGD:621414 UniProtKB:O18965 UniProtKB:Q12809 ZFIN:ZDB-GENE-040702-5 ZFIN:ZDB-GENE-061226-1 ZFIN:ZDB-GENE-070912-23 ZFIN:ZDB-GENE-121128-4	F	Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:7889573^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:8995352^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12809	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24931372^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12809	F	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F	Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003938 InterPro:IPR003967	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003938 InterPro:IPR003967	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003938 InterPro:IPR003967 InterPro:IPR005821	C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
involved_in	GO:0003064	regulation of heart rate by hormone	PMID:11953308^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061337	cardiac conduction	Reactome:R-HSA-5576890	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5577237 Reactome:R-HSA-1296127	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0633	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	P	Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Trudeau, MC et al. (1995) HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269 92-5 PubMed GONUTS page
↑ Phan, K et al. (2017) The S1 helix critically regulates the finely tuned gating of Kv11.1 channels. J. Biol. Chem. 292 7688-7705 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Kupershmidt, S et al. (2003) The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. FASEB J. 17 2263-5 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gianulis, EC & Trudeau, MC (2011) Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels. J. Biol. Chem. 286 22160-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Roder, K et al. (2014) RING finger protein RNF207, a novel regulator of cardiac excitation. J. Biol. Chem. 289 33730-40 PubMed GONUTS page
↑ Lin, J et al. (2008) The regulation of the cardiac potassium channel (HERG) by caveolin-1. Biochem. Cell Biol. 86 405-15 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Smith, PL et al. (1996) The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379 833-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Sanguinetti, MC et al. (1995) A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81 299-307 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Kagan, A et al. (2002) 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity. EMBO J. 21 1889-98 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Albesa, M et al. (2011) Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1. J. Mol. Cell. Cardiol. 51 90-8 PubMed GONUTS page
↑ ^11.0 ^11.1 Eckey, K et al. (2010) Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT). Cell. Physiol. Biochem. 26 503-12 PubMed GONUTS page
↑ ^12.0 ^12.1 Li, X et al. (1997) The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression. J. Biol. Chem. 272 705-8 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Curran, ME et al. (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80 795-803 PubMed GONUTS page
↑ Li, Q et al. (2014) Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel. FEBS Lett. 588 2782-8 PubMed GONUTS page

[PMID:7604285-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Trudeau, MC et al. (1995) HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269 92-5 PubMed GONUTS page

[PMID:28280240-2] Phan, K et al. (2017) The S1 helix critically regulates the finely tuned gating of Kv11.1 channels. J. Biol. Chem. 292 7688-7705 PubMed GONUTS page

[PMID:14525949-3] 3.0 ^3.1 ^3.2 Kupershmidt, S et al. (2003) The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. FASEB J. 17 2263-5 PubMed GONUTS page

[PMID:21536673-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gianulis, EC & Trudeau, MC (2011) Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels. J. Biol. Chem. 286 22160-9 PubMed GONUTS page

[PMID:25281747-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Roder, K et al. (2014) RING finger protein RNF207, a novel regulator of cardiac excitation. J. Biol. Chem. 289 33730-40 PubMed GONUTS page

[PMID:18923542-6] Lin, J et al. (2008) The regulation of the cardiac potassium channel (HERG) by caveolin-1. Biochem. Cell Biol. 86 405-15 PubMed GONUTS page

[PMID:8587608-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Smith, PL et al. (1996) The inward rectification mechanism of the HERG cardiac potassium channel. Nature 379 833-6 PubMed GONUTS page

[PMID:7736582-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Sanguinetti, MC et al. (1995) A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81 299-307 PubMed GONUTS page

[PMID:11953308-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Kagan, A et al. (2002) 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity. EMBO J. 21 1889-98 PubMed GONUTS page

[PMID:21463633-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Albesa, M et al. (2011) Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1. J. Mol. Cell. Cardiol. 51 90-8 PubMed GONUTS page

[PMID:21063088-11] 11.0 ^11.1 Eckey, K et al. (2010) Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT). Cell. Physiol. Biochem. 26 503-12 PubMed GONUTS page

[PMID:8995352-12] 12.0 ^12.1 Li, X et al. (1997) The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression. J. Biol. Chem. 272 705-8 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7889573-14] Curran, ME et al. (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80 795-803 PubMed GONUTS page

[PMID:24931372-15] Li, Q et al. (2014) Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel. FEBS Lett. 588 2782-8 PubMed GONUTS page

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HUMAN:KCNH2

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