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HUMAN:KCNE2
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | KCNE2 | |
Protein Name(s) | Potassium voltage-gated channel subfamily E member 2
MinK-related peptide 1 Minimum potassium ion channel-related peptide 1 Potassium channel subunit beta MiRP1 | |
External Links | ||
UniProt | Q9Y6J6 | |
EMBL | AF071002 AF302095 DQ784804 CH471079 BC093892 BC112087 | |
CCDS | CCDS13635.1 | |
RefSeq | NP_751951.1 | |
UniGene | Hs.551521 Hs.736062 | |
PDB | 2M0Q | |
PDBsum | 2M0Q | |
ProteinModelPortal | Q9Y6J6 | |
SMR | Q9Y6J6 | |
BioGrid | 115313 | |
STRING | 9606.ENSP00000290310 | |
PhosphoSite | Q9Y6J6 | |
DMDM | 6685661 | |
PRIDE | Q9Y6J6 | |
DNASU | 9992 | |
Ensembl | ENST00000290310 | |
GeneID | 9992 | |
KEGG | hsa:9992 | |
UCSC | uc002ytt.1 | |
CTD | 9992 | |
GeneCards | GC21P035736 | |
GeneReviews | KCNE2 | |
HGNC | HGNC:6242 | |
HPA | CAB022640 | |
MIM | 603796 611493 613693 | |
neXtProt | NX_Q9Y6J6 | |
Orphanet | 334 101016 | |
PharmGKB | PA392 | |
eggNOG | NOG43841 | |
GeneTree | ENSGT00510000048894 | |
HOGENOM | HOG000113208 | |
HOVERGEN | HBG052227 | |
InParanoid | Q9Y6J6 | |
KO | K04896 | |
OMA | WRRNTTA | |
OrthoDB | EOG7WDN4J | |
PhylomeDB | Q9Y6J6 | |
TreeFam | TF336058 | |
GeneWiki | KCNE2 | |
GenomeRNAi | 9992 | |
NextBio | 37747 | |
PRO | PR:Q9Y6J6 | |
Proteomes | UP000005640 | |
Bgee | Q9Y6J6 | |
CleanEx | HS_KCNE2 | |
ExpressionAtlas | Q9Y6J6 | |
Genevestigator | Q9Y6J6 | |
GO | GO:0009986 GO:0005764 GO:0005886 GO:0008076 GO:0005251 GO:0005242 GO:0044325 GO:0015459 GO:1902282 GO:0007568 GO:0086002 GO:0034613 GO:0035690 GO:0086009 GO:0086011 GO:1901800 GO:0071435 GO:0010107 GO:0071805 GO:1902159 GO:1902259 GO:0086091 GO:1901979 GO:0060306 GO:1901379 GO:0060307 GO:0043586 GO:0086005 | |
InterPro | IPR000369 IPR005424 IPR005425 | |
PANTHER | PTHR17028 | |
Pfam | PF02060 | |
PRINTS | PR01605 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0006811 |
ion transport |
ECO:0000247 |
UniProtKB: |
P |
Figure 4: Activation time constants for Ih in pyramidal cells were fast in both genotypes compared to those in VB neurons, Kcne2 deletion again increased time constants in pyramidal neurons Figure 6: he frequency of spontaneous EPSPs in layer 6 pyramidal neurons in the absence of 4-AP was increased by Kcne2 deletion, suggesting a possible alteration in glutamate release machinery. |
complete | ||||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902260 |
negative regulation of delayed rectifier potassium channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0098915 |
membrane repolarization during ventricular cardiac muscle cell action potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:1902282 |
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902259 |
regulation of delayed rectifier potassium channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901979 |
regulation of inward rectifier potassium channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901800 |
positive regulation of proteasomal protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:Q12809) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901379 |
regulation of potassium ion transmembrane transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0086091 |
regulation of heart rate by cardiac conduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0086011 |
membrane repolarization during action potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0086009 |
membrane repolarization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0086005 |
ventricular cardiac muscle cell action potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0086002 |
cardiac muscle cell action potential involved in contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097623 |
potassium ion export across plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060307 |
regulation of ventricular cardiac muscle cell membrane repolarization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060306 |
regulation of membrane repolarization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044325 |
ion channel binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035690 |
cellular response to drug |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1990573 |
potassium ion import across plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000746) |
Seeded From UniProt |
complete | ||
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0005242 |
inward rectifier potassium channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005764 |
lysosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
contributes_to |
GO:1902282 |
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902260 |
negative regulation of delayed rectifier potassium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097623 |
potassium ion export across plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0086091 |
regulation of heart rate by cardiac conduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96673 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0086011 |
membrane repolarization during action potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0086005 |
ventricular cardiac muscle cell action potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1891123 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060307 |
regulation of ventricular cardiac muscle cell membrane repolarization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1891123 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0044325 |
ion channel binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96673 |
F |
Seeded From UniProt |
complete | ||
colocalizes_with |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
C |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:1990573 |
potassium ion import across plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903817 |
negative regulation of voltage-gated potassium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902260 |
negative regulation of delayed rectifier potassium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902259 |
regulation of delayed rectifier potassium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902159 |
regulation of cyclic nucleotide-gated ion channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901979 |
regulation of inward rectifier potassium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901387 |
positive regulation of voltage-gated calcium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1901379 |
regulation of potassium ion transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097623 |
potassium ion export across plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0086011 |
membrane repolarization during action potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0086009 |
membrane repolarization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060306 |
regulation of membrane repolarization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0044325 |
ion channel binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043586 |
tongue development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035690 |
cellular response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0009986 |
cell surface |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007568 |
aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005242 |
inward rectifier potassium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P63161 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061337 |
cardiac conduction |
Reactome:R-HSA-5576893 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-5577237 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034765 |
regulation of ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005267 |
potassium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ying, SW et al. (2012) Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS ONE 7 e42756 PubMed GONUTS page
- ↑ Roura-Ferrer, M et al. (2010) Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting. J. Cell. Physiol. 225 692-700 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 McCrossan, ZA et al. (2009) Regulation of the Kv2.1 potassium channel by MinK and MiRP1. J. Membr. Biol. 228 1-14 PubMed GONUTS page
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 Abbott, GW et al. (1999) MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97 175-87 PubMed GONUTS page
- ↑ 5.0 5.1 Zhang, M et al. (2012) KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner. Am. J. Physiol. Heart Circ. Physiol. 302 H910-22 PubMed GONUTS page
- ↑ 6.0 6.1 Hu, YH et al. (2006) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics 7 155 PubMed GONUTS page
- ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
i
m
n
p
- GO:0005886 ! plasma membrane
- GO:1901387 ! positive regulation of voltage-gated calcium channel activity
- GO:1901800 ! positive regulation of proteasomal protein catabolic process
- GO:0005267 ! potassium channel activity
- GO:0015459 ! potassium channel regulator activity
- GO:0071805 ! potassium ion transmembrane transport
- GO:0097623 ! potassium ion export across plasma membrane
- GO:0006813 ! potassium ion transport
- GO:1990573 ! potassium ion import across plasma membrane
- Primates
- GO:0042803 ! protein homodimerization activity
r
- GO:0060306 ! regulation of membrane repolarization
- GO:0060307 ! regulation of ventricular cardiac muscle cell membrane repolarization
- GO:1902259 ! regulation of delayed rectifier potassium channel activity
- GO:1901979 ! regulation of inward rectifier potassium channel activity
- GO:1901379 ! regulation of potassium ion transmembrane transport
- GO:0086091 ! regulation of heart rate by cardiac conduction
- GO:0034765 ! regulation of monoatomic ion transmembrane transport
- GO:1902159 ! regulation of cyclic nucleotide-gated ion channel activity
v
- GO:0086005 ! ventricular cardiac muscle cell action potential
- Vertebrata
- GO:0005249 ! voltage-gated potassium channel activity
- GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
- GO:0005244 ! voltage-gated monoatomic ion channel activity
- GO:0008076 ! voltage-gated potassium channel complex