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MOUSE:KCNE2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Kcne2 | |
| Protein Name(s) | Potassium voltage-gated channel subfamily E member 2
MinK-related peptide 1 Minimum potassium ion channel-related peptide 1 Potassium channel subunit beta MiRP1 | |
| External Links | ||
| UniProt | Q9D808 | |
| EMBL | AK008619 BC022699 | |
| CCDS | CCDS28333.1 | |
| RefSeq | NP_598871.1 XP_006523096.1 | |
| UniGene | Mm.156736 | |
| ProteinModelPortal | Q9D808 | |
| SMR | Q9D808 | |
| TCDB | 8.A.10.2.1 | |
| PhosphoSite | Q9D808 | |
| PRIDE | Q9D808 | |
| Ensembl | ENSMUST00000047383 ENSMUST00000113971 | |
| GeneID | 246133 | |
| KEGG | mmu:246133 | |
| UCSC | uc007zyw.2 | |
| CTD | 9992 | |
| MGI | MGI:1891123 | |
| eggNOG | NOG43841 | |
| GeneTree | ENSGT00510000048894 | |
| HOGENOM | HOG000113208 | |
| HOVERGEN | HBG052227 | |
| InParanoid | Q9D808 | |
| KO | K04896 | |
| OrthoDB | EOG7WDN4J | |
| PhylomeDB | Q9D808 | |
| TreeFam | TF336058 | |
| NextBio | 387099 | |
| PRO | PR:Q9D808 | |
| Proteomes | UP000000589 | |
| Bgee | Q9D808 | |
| Genevestigator | Q9D808 | |
| GO | GO:0009986 GO:0005764 GO:0016020 GO:0005886 GO:0008076 GO:0005251 GO:0005242 GO:0044325 GO:0015459 GO:1902282 GO:0007568 GO:0086002 GO:0034613 GO:0035690 GO:0086009 GO:0086011 GO:1901800 GO:0071435 GO:0010107 GO:0071805 GO:1902159 GO:1902259 GO:0086091 GO:1901979 GO:0060306 GO:1901379 GO:0060307 GO:0043586 GO:0086005 | |
| InterPro | IPR000369 IPR005424 IPR005425 | |
| PANTHER | PTHR17028 | |
| Pfam | PF02060 | |
| PRINTS | PR01605 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
colocalizes_with |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902260 |
negative regulation of delayed rectifier potassium channel activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:1902282 |
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902260 |
negative regulation of delayed rectifier potassium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097623 |
potassium ion export across plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0086091 |
regulation of heart rate by cardiac conduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96673 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0086011 |
membrane repolarization during action potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0086005 |
ventricular cardiac muscle cell action potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1891123 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060307 |
regulation of ventricular cardiac muscle cell membrane repolarization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1891123 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96673 |
F |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001445835 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1990573 |
potassium ion import across plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1990573 |
potassium ion import across plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1903817 |
negative regulation of voltage-gated potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:1902282 |
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902260 |
negative regulation of delayed rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902260 |
negative regulation of delayed rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1902259 |
regulation of delayed rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902259 |
regulation of delayed rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1902159 |
regulation of cyclic nucleotide-gated ion channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1901979 |
regulation of inward rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1901979 |
regulation of inward rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1901800 |
positive regulation of proteasomal protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1901387 |
positive regulation of voltage-gated calcium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1901379 |
regulation of potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1901379 |
regulation of potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0098915 |
membrane repolarization during ventricular cardiac muscle cell action potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0097623 |
potassium ion export across plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0097623 |
potassium ion export across plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0086091 |
regulation of heart rate by cardiac conduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0086011 |
membrane repolarization during action potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0086011 |
membrane repolarization during action potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0086009 |
membrane repolarization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0086009 |
membrane repolarization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0086005 |
ventricular cardiac muscle cell action potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3699589 |
P |
regulates_o_occurs_in:(CL:0002131) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0086005 |
ventricular cardiac muscle cell action potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0086002 |
cardiac muscle cell action potential involved in contraction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3699589 |
P |
occurs_in:(CL:0002131) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0060307 |
regulation of ventricular cardiac muscle cell membrane repolarization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3699589 |
P |
regulates_o_occurs_in:(CL:0002131) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0060307 |
regulation of ventricular cardiac muscle cell membrane repolarization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060306 |
regulation of membrane repolarization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060306 |
regulation of membrane repolarization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0035690 |
cellular response to drug |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035690 |
cellular response to drug |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0034613 |
cellular protein localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3699589 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
C |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0005251 |
delayed rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
F |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0005242 |
inward rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0005242 |
inward rectifier potassium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621383 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005249 |
voltage-gated potassium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034765 |
regulation of ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005267 |
potassium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Roepke, TK et al. (2008) Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f). FASEB J. 22 3648-60 PubMed GONUTS page
c
i
m
- Mammalia
- GO:0016020 ! membrane
- GO:0086011 ! membrane repolarization during action potential
- GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential
- GO:0086009 ! membrane repolarization
- Metazoa
- GO:0006811 ! monoatomic ion transport
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
n
p
- GO:0005886 ! plasma membrane
- GO:1901387 ! positive regulation of voltage-gated calcium channel activity
- GO:1901800 ! positive regulation of proteasomal protein catabolic process
- GO:0015459 ! potassium channel regulator activity
- GO:0005267 ! potassium channel activity
- GO:0071805 ! potassium ion transmembrane transport
- GO:0097623 ! potassium ion export across plasma membrane
- GO:0006813 ! potassium ion transport
- GO:1990573 ! potassium ion import across plasma membrane
- GO:0042803 ! protein homodimerization activity
r
- GO:0086091 ! regulation of heart rate by cardiac conduction
- GO:0060307 ! regulation of ventricular cardiac muscle cell membrane repolarization
- GO:1902259 ! regulation of delayed rectifier potassium channel activity
- GO:1902159 ! regulation of cyclic nucleotide-gated ion channel activity
- GO:0034765 ! regulation of monoatomic ion transmembrane transport
- GO:1901379 ! regulation of potassium ion transmembrane transport
- GO:0060306 ! regulation of membrane repolarization
- Rodentia
v
- GO:0086005 ! ventricular cardiac muscle cell action potential
- Vertebrata
- GO:0005244 ! voltage-gated monoatomic ion channel activity
- GO:0005249 ! voltage-gated potassium channel activity
- GO:1902282 ! voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
- GO:0008076 ! voltage-gated potassium channel complex
