CHICK:Q9W610

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ATF4 (ECO:0000313 with EMBL:BAA76466.1)
Protein Name(s)	ATF4 (ECO:0000313 with EMBL:BAA76466.1)
External Links
UniProt	Q9W610
EMBL	AB013138
RefSeq	NP_990211.1
UniGene	Gga.3457
ProteinModelPortal	Q9W610
SMR	Q9W610
STRING	9031.ENSGALP00000019797
GeneID	395693
KEGG	gga:395693
CTD	468
eggNOG	NOG325856
HOGENOM	HOG000004844
HOVERGEN	HBG004301
InParanoid	Q9W610
KO	K04374
OrthoDB	EOG72JWGW
PhylomeDB	Q9W610
TreeFam	TF316136
NextBio	20815765
PRO	PR:Q9W610
GO	GO:0043565 GO:0003700
InterPro	IPR029811 IPR004827
PANTHER	PTHR13044:SF2
Pfam	PF00170
SMART	SM00338
PROSITE	PS50217 PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88096 PANTHER:PTN000315889 UniProtKB:P18848	P	Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000315889 RGD:621863 UniProtKB:P18848	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2141857 MGI:MGI:88096 PANTHER:PTN000315883 WB:WBGene00013878	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2141857 MGI:MGI:88096 PANTHER:PTN000315883 RGD:621863 RGD:628902 UniProtKB:P18848 UniProtKB:Q9Y2D1 WB:WBGene00000221 WB:WBGene00013878	C	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88096 PANTHER:PTN000315883 UniProtKB:P18848 WB:WBGene00013878	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000315883 UniProtKB:Q9Y2D1	F	Seeded From UniProt	complete
part_of	GO:1990617	CHOP-ATF4 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
part_of	GO:1990590	ATF1-ATF4 transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
part_of	GO:1990589	ATF4-CREB1 transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
part_of	GO:1990037	Lewy body core	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
involved_in	GO:1903204	negative regulation of oxidative stress-induced neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
involved_in	GO:0045943	positive regulation of transcription by RNA polymerase I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	F	Seeded From UniProt	complete
enables	GO:0043522	leucine zipper domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	F	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
part_of	GO:0034399	nuclear periphery	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	F	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	F	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18848 ensembl:ENSP00000336790	F	Seeded From UniProt	complete
involved_in	GO:2000120	positive regulation of sodium-dependent phosphate transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
part_of	GO:1990590	ATF1-ATF4 transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C	Seeded From UniProt	complete
part_of	GO:1990589	ATF4-CREB1 transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C	Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C	Seeded From UniProt	complete
involved_in	GO:0070169	positive regulation of biomineral tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0036499	PERK-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827 InterPro:IPR029811	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029811	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029811	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029811	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:Q9W610

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