CHICK:O42391

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	PIK3CA (ECO:0000313 with Ensembl:ENSGALP00000014504)
Protein Name(s)	Phosphoinositide 3-kinase catalytic subunit (ECO:0000313 with EMBL:AAB62534.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000014504)
External Links
UniProt	O42391
EMBL	AADN03005820 AF001076
RefSeq	NP_001004410.1
STRING	9031.ENSGALP00000038717
Ensembl	ENSGALT00000014520
GeneID	424971
KEGG	gga:424971
CTD	5290
eggNOG	COG5032
GeneTree	ENSGT00760000119110
HOGENOM	HOG000252911
HOVERGEN	HBG052721
KO	K00922
OMA	AFAVRCL
OrthoDB	EOG70CR65
PhylomeDB	O42391
Reactome	REACT_189761 REACT_194391 REACT_194994 REACT_196847 REACT_196849 REACT_196855 REACT_197116 REACT_197520 REACT_198076 REACT_198138 REACT_198205 REACT_198215 REACT_207556 REACT_217737 REACT_230602 REACT_239808 REACT_240004 REACT_241446 REACT_242801 REACT_243112 REACT_244511 REACT_244793 REACT_244921 REACT_249636 REACT_250039 REACT_250045 REACT_251572 REACT_251680 REACT_254784 REACT_254874
NextBio	20827229
Proteomes	UP000000539
GO	GO:0030027 GO:0005943 GO:0016303 GO:0005524 GO:0030295 GO:0006006 GO:0044029 GO:2000811 GO:2000270 GO:0043524 GO:0048015 GO:0033138 GO:0043491 GO:0006468 GO:2000653 GO:0040014
Gene3D	1.10.1070.11 1.25.40.70 2.60.40.150
InterPro	IPR016024 IPR000008 IPR011009 IPR000403 IPR018936 IPR003113 IPR002420 IPR000341 IPR015433 IPR001263 IPR029071
PANTHER	PTHR10048
Pfam	PF00454 PF00792 PF02192 PF00794 PF00613
SMART	SM00239 SM00142 SM00143 SM00144 SM00145 SM00146
SUPFAM	SSF48371 SSF49562 SSF54236 SSF56112
PROSITE	PS00915 PS00916 PS50290 PS51544 PS51547 PS51546 PS51545

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0097485	neuron projection guidance	PMID:16912080^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0006215)	Seeded From UniProt	complete
involved_in	GO:0030031	cell projection assembly	PMID:16912080^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0006215)	Seeded From UniProt	complete
part_of	GO:0032584	growth cone membrane	PMID:21041312^[2]	ECO:0000305	curator inference used in manual assertion	GO:0046934	C		Seeded From UniProt	complete
enables	GO:1902379	chemoattractant activity involved in axon guidance	PMID:21041312^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:1001451) has_participant:(CHEBI:29108) has_participant:(CHEBI:16618)	Seeded From UniProt	complete
involved_in	GO:0072383	plus-end-directed vesicle transport along microtubule	PMID:21041312^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001451)	Seeded From UniProt	complete
enables	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PMID:21041312^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:1001451)	Seeded From UniProt	complete
involved_in	GO:0098586	cellular response to virus	PMID:21723579^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007163	establishment or maintenance of cell polarity	PMID:17240336^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:12967912^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090527	actin filament reorganization	PMID:12967912^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:12967912^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:620899 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P		Seeded From UniProt	complete
enables	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005743 UniProtKB:O42391	F		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015277 FB:FBgn0015278 FB:FBgn0015279 FB:FBgn0267350 MGI:MGI:2448506 PANTHER:PTN000005673 RGD:620916 RGD:620917 SGD:S000004230 SGD:S000004296 SGD:S000005211 UniProtKB:A0A1D8PDV7 UniProtKB:P32871	P		Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1203729 MGI:MGI:2685045 PANTHER:PTN000005674 WB:WBGene00009552	P		Seeded From UniProt	complete
enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 PANTHER:PTN000005674 RGD:620231	F		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922019 PANTHER:PTN000799655	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 UniProtKB:O42391	P		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 MGI:MGI:1203729 MGI:MGI:1206581 MGI:MGI:1922019 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P42336	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 PomBase:SPAC458.05 TAIR:locus:2164401 UniProtKB:P48736	C		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015279 PANTHER:PTN000005674 UniProtKB:O00329 UniProtKB:P42338 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1206581 MGI:MGI:1353576 PANTHER:PTN000799655	P		Seeded From UniProt	complete
part_of	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002225407 UniProtKB:P42336	C		Seeded From UniProt	complete
part_of	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005748 UniProtKB:P42336	C		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1206581 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P32871 WB:WBGene00000090	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 RGD:620231 UniProtKB:O00443 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:621214 UniProtKB:O00443 UniProtKB:P42356 UniProtKB:P48736 WB:WBGene00000090 WB:WBGene00006932 WB:WBGene00009552 dictyBase:DDB_G0291093	C		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1902379	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0030295	P		Seeded From UniProt	complete
involved_in	GO:0061642	chemoattraction of axon	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1902379	P		Seeded From UniProt	complete
involved_in	GO:2000653	regulation of genetic imprinting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:2000270	negative regulation of fibroblast apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0060612	adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0044029	hypomethylation of CpG island	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0043457	regulation of cellular respiration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
enables	GO:0030295	protein kinase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	F		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	C		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	F		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	C		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42337 ensembl:ENSMUSP00000029201	P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42336 ensembl:ENSP00000263967	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42336 ensembl:ENSP00000263967	P		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42336 ensembl:ENSP00000263967	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42336 ensembl:ENSP00000263967	F		Seeded From UniProt	complete
part_of	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42336 ensembl:ENSP00000263967	C		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037704	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290	F		Seeded From UniProt	complete
enables	GO:0035004	phosphatidylinositol 3-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037704	F		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P		Seeded From UniProt	complete
enables	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.153	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000114506	F		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000399976	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000415644	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000415644	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Sakakibara, A & Horwitz, AF (2006) Mechanism of polarized protrusion formation on neuronal precursors migrating in the developing chicken cerebellum. J. Cell. Sci. 119 3583-92 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Akiyama, H & Kamiguchi, H (2010) Phosphatidylinositol 3-kinase facilitates microtubule-dependent membrane transport for neuronal growth cone guidance. J. Biol. Chem. 285 41740-8 PubMed GONUTS page
↑ Wei, L et al. (2011) Infectious bursal disease virus activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by interaction of VP5 protein with the p85α subunit of PI3K. Virology 417 211-20 PubMed GONUTS page
↑ Leslie, NR et al. (2007) PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr. Biol. 17 115-25 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Qian, Y et al. (2004) PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. Am. J. Physiol., Cell Physiol. 286 C153-63 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16912080-1] 1.0 ^1.1 Sakakibara, A & Horwitz, AF (2006) Mechanism of polarized protrusion formation on neuronal precursors migrating in the developing chicken cerebellum. J. Cell. Sci. 119 3583-92 PubMed GONUTS page

[PMID:21041312-2] 2.0 ^2.1 ^2.2 ^2.3 Akiyama, H & Kamiguchi, H (2010) Phosphatidylinositol 3-kinase facilitates microtubule-dependent membrane transport for neuronal growth cone guidance. J. Biol. Chem. 285 41740-8 PubMed GONUTS page

[PMID:21723579-3] Wei, L et al. (2011) Infectious bursal disease virus activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by interaction of VP5 protein with the p85α subunit of PI3K. Virology 417 211-20 PubMed GONUTS page

[PMID:17240336-4] Leslie, NR et al. (2007) PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr. Biol. 17 115-25 PubMed GONUTS page

[PMID:12967912-5] 5.0 ^5.1 ^5.2 Qian, Y et al. (2004) PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. Am. J. Physiol., Cell Physiol. 286 C153-63 PubMed GONUTS page

[PMID:21873635-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:O42391

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