CAEEL:DCR1

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	dcr-1
Protein Name(s)	Endoribonuclease dcr-1
External Links
UniProt	P34529
EMBL	FO081380
PIR	S44849
RefSeq	NP_498761.2
UniGene	Cel.38691
ProteinModelPortal	P34529
SMR	P34529
BioGrid	41344
DIP	DIP-25340N
IntAct	P34529
MINT	MINT-1040079
STRING	6239.K12H4.8
PaxDb	P34529
PRIDE	P34529
EnsemblMetazoa	K12H4.8
GeneID	176138
KEGG	cel:CELE_K12H4.8
UCSC	K12H4.8
CTD	42693
WormBase	K12H4.8
eggNOG	COG1111
GeneTree	ENSGT00510000046789
HOGENOM	HOG000022395
InParanoid	P34529
KO	K11592
OMA	KHFIAMC
OrthoDB	EOG78PV82
NextBio	891290
PRO	PR:P34529
Proteomes	UP000001940
GO	GO:0005829 GO:0005524 GO:0004530 GO:0004386 GO:0046872 GO:0004525 GO:0003723 GO:0006309 GO:0000737 GO:0031050 GO:0035262 GO:0002119 GO:0008355 GO:2000636 GO:0031054 GO:0030422 GO:0040034 GO:0000003 GO:0006401 GO:0090501 GO:0090502 GO:0016075
Gene3D	1.10.1520.10 3.40.50.300
HAMAP	MF_00104
InterPro	IPR011545 IPR005034 IPR014720 IPR014001 IPR001650 IPR027417 IPR003100 IPR011907 IPR000999
Pfam	PF00270 PF03368 PF00271 PF02170 PF00636
SMART	SM00487 SM00358 SM00490 SM00949 SM00535
SUPFAM	SSF101690 SSF52540 SSF69065
PROSITE	PS51327 PS50137 PS51192 PS51194 PS50821 PS00517 PS50142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005634	nucleus	PMID:25490268^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0030422	production of siRNA involved in RNA interference	PMID:20133583^[2]	ECO:0000315			P		Figure 4	complete CACAO 7438
part_of	GO:0005737	cytoplasm	PMID:25490268^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:20133583^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008355	olfactory learning	PMID:23993094^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(CHEBI:28398)	Seeded From UniProt	complete
involved_in	GO:2000636	positive regulation of primary miRNA processing	PMID:15531879^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040034	regulation of development, heterochronic	PMID:11641272^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00239410	P		Seeded From UniProt	complete
involved_in	GO:0035262	gonad morphogenesis	PMID:11486053^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:15531879^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:19734881^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031050	dsRNA processing	PMID:11461699^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:11641272^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00239410	P		Seeded From UniProt	complete
involved_in	GO:0006401	RNA catabolic process	PMID:20223951^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006309	apoptotic DNA fragmentation	PMID:20223951^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00003828	P		Seeded From UniProt	complete
involved_in	GO:0006309	apoptotic DNA fragmentation	PMID:20223951^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000795	P		Seeded From UniProt	complete
involved_in	GO:0006309	apoptotic DNA fragmentation	PMID:20223951^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000787	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11641272^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16439208^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004530	deoxyribonuclease I activity	PMID:20223951^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:19734881^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:20223951^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002119	nematode larval development	PMID:11461699^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00091550	P		Seeded From UniProt	complete
involved_in	GO:0000737	DNA catabolic process, endonucleolytic	PMID:20223951^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000003	reproduction	PMID:11641272^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00239410	P		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 MGI:MGI:2177178 PANTHER:PTN001029377 UniProtKB:Q9UPY3 WB:WBGene00000939	P		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 MGI:MGI:2177178 PANTHER:PTN000383724 PomBase:SPCC188.13c UniProtKB:Q9LXW7 UniProtKB:Q9UPY3 WB:WBGene00000939	P		Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 PANTHER:PTN000383724 UniProtKB:Q9UPY3	C		Seeded From UniProt	complete
involved_in	GO:0006309	apoptotic DNA fragmentation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001029377 WB:WBGene00000939	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 MGI:MGI:2177178 PANTHER:PTN000383724 PomBase:SPCC188.13c TAIR:locus:2092409 WB:WBGene00000939	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 PANTHER:PTN000383724 PomBase:SPCC188.13c TAIR:locus:2092409 UniProtKB:P84634 UniProtKB:Q9LXW7 UniProtKB:Q9SP32 WB:WBGene00000939	C		Seeded From UniProt	complete
enables	GO:0004530	deoxyribonuclease I activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001029377 WB:WBGene00000939	F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 MGI:MGI:2177178 PANTHER:PTN000383724 TAIR:locus:2092409 UniProtKB:Q9UPY3 WB:WBGene00000939	F		Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004525	P		Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004525	P		Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004525	P		Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004525	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004525	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016891	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004525	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004525	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004525	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011907	F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000999 InterPro:IPR011907 InterPro:IPR036389	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
involved_in	GO:0006396	RNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000999 InterPro:IPR036389	P		Seeded From UniProt	complete
involved_in	GO:0016075	rRNA catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011907	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
enables	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005034	F		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Drake, M et al. (2014) A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans. Dev. Cell 31 614-28 PubMed GONUTS page
↑ ^2.0 ^2.1 Vasale, JJ et al. (2010) Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. Proc. Natl. Acad. Sci. U.S.A. 107 3582-7 PubMed GONUTS page
↑ Juang, BT et al. (2013) Endogenous nuclear RNAi mediates behavioral adaptation to odor. Cell 154 1010-22 PubMed GONUTS page
↑ ^4.0 ^4.1 Denli, AM et al. (2004) Processing of primary microRNAs by the Microprocessor complex. Nature 432 231-5 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ketting, RF et al. (2001) Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15 2654-9 PubMed GONUTS page
↑ Knight, SW & Bass, BL (2001) A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 293 2269-71 PubMed GONUTS page
↑ ^7.0 ^7.1 Chatterjee, S & Grosshans, H (2009) Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature 461 546-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Grishok, A et al. (2001) Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106 23-34 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Nakagawa, A et al. (2010) Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science 328 327-34 PubMed GONUTS page
↑ Duchaine, TF et al. (2006) Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell 124 343-54 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25490268-1] 1.0 ^1.1 Drake, M et al. (2014) A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans. Dev. Cell 31 614-28 PubMed GONUTS page

[PMID:20133583-2] 2.0 ^2.1 Vasale, JJ et al. (2010) Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. Proc. Natl. Acad. Sci. U.S.A. 107 3582-7 PubMed GONUTS page

[PMID:23993094-3] Juang, BT et al. (2013) Endogenous nuclear RNAi mediates behavioral adaptation to odor. Cell 154 1010-22 PubMed GONUTS page

[PMID:15531879-4] 4.0 ^4.1 Denli, AM et al. (2004) Processing of primary microRNAs by the Microprocessor complex. Nature 432 231-5 PubMed GONUTS page

[PMID:11641272-5] 5.0 ^5.1 ^5.2 ^5.3 Ketting, RF et al. (2001) Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15 2654-9 PubMed GONUTS page

[PMID:11486053-6] Knight, SW & Bass, BL (2001) A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 293 2269-71 PubMed GONUTS page

[PMID:19734881-7] 7.0 ^7.1 Chatterjee, S & Grosshans, H (2009) Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature 461 546-9 PubMed GONUTS page

[PMID:11461699-8] 8.0 ^8.1 Grishok, A et al. (2001) Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106 23-34 PubMed GONUTS page

[PMID:20223951-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Nakagawa, A et al. (2010) Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science 328 327-34 PubMed GONUTS page

[PMID:16439208-10] Duchaine, TF et al. (2006) Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell 124 343-54 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:DCR1

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