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CAEEL:DCR1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) dcr-1
Protein Name(s) Endoribonuclease dcr-1
External Links
UniProt P34529
EMBL FO081380
PIR S44849
RefSeq NP_498761.2
UniGene Cel.38691
ProteinModelPortal P34529
SMR P34529
BioGrid 41344
DIP DIP-25340N
IntAct P34529
MINT MINT-1040079
STRING 6239.K12H4.8
PaxDb P34529
PRIDE P34529
EnsemblMetazoa K12H4.8
GeneID 176138
KEGG cel:CELE_K12H4.8
UCSC K12H4.8
CTD 42693
WormBase K12H4.8
eggNOG COG1111
GeneTree ENSGT00510000046789
HOGENOM HOG000022395
InParanoid P34529
KO K11592
OMA KHFIAMC
OrthoDB EOG78PV82
NextBio 891290
PRO PR:P34529
Proteomes UP000001940
GO GO:0005829
GO:0005524
GO:0004530
GO:0004386
GO:0046872
GO:0004525
GO:0003723
GO:0006309
GO:0000737
GO:0031050
GO:0035262
GO:0002119
GO:0008355
GO:2000636
GO:0031054
GO:0030422
GO:0040034
GO:0000003
GO:0006401
GO:0090501
GO:0090502
GO:0016075
Gene3D 1.10.1520.10
3.40.50.300
HAMAP MF_00104
InterPro IPR011545
IPR005034
IPR014720
IPR014001
IPR001650
IPR027417
IPR003100
IPR011907
IPR000999
Pfam PF00270
PF03368
PF00271
PF02170
PF00636
SMART SM00487
SM00358
SM00490
SM00949
SM00535
SUPFAM SSF101690
SSF52540
SSF69065
PROSITE PS51327
PS50137
PS51192
PS51194
PS50821
PS00517
PS50142

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000003

reproduction

PMID:11641272[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00239410

P

Seeded From UniProt

complete

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0000737

DNA catabolic process, endonucleolytic

PMID:20223951[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0002119

nematode larval development

PMID:11461699[3]

IMP: Inferred from Mutant Phenotype

WB:WBVar00091550

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006935

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000999
InterPro:IPR011907

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000383724

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

GO:0004386

helicase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

GO:0004518

nuclease activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

GO:0004519

endonuclease activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

GO:0004525

ribonuclease III activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000999
InterPro:IPR011907

F

Seeded From UniProt

complete

GO:0004525

ribonuclease III activity

PMID:19734881[4]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0004525

ribonuclease III activity

PMID:20223951[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004530

deoxyribonuclease I activity

PMID:20223951[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006935

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000383724

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:25490268[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000383724

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:25490268[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005829

cytosol

PMID:11641272[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030422

production of siRNA involved in RNA interference

PMID:20133583[6]

IMP: Inferred from Mutant Phenotype

P

Figure 4

complete
CACAO 7438

GO:0005829

cytosol

PMID:16439208[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006309

apoptotic DNA fragmentation

PMID:20223951[2]

IGI: Inferred from Genetic Interaction

WB:WBGene00000787

P

Seeded From UniProt

complete

GO:0006309

apoptotic DNA fragmentation

PMID:20223951[2]

IGI: Inferred from Genetic Interaction

WB:WBGene00000795

P

Seeded From UniProt

complete

GO:0006309

apoptotic DNA fragmentation

PMID:20223951[2]

IGI: Inferred from Genetic Interaction

WB:WBGene00003828

P

Seeded From UniProt

complete

GO:0006396

RNA processing

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000999

P

Seeded From UniProt

complete

GO:0006401

RNA catabolic process

PMID:20223951[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008355

olfactory learning

PMID:23993094[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016075

rRNA catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011907

P

Seeded From UniProt

complete

GO:0016442

RISC complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000383724

C

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006935

F

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016891

endoribonuclease activity, producing 5'-phosphomonoesters

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005034

F

Seeded From UniProt

complete

GO:0030422

production of siRNA involved in RNA interference

PMID:11641272[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00239410

P

Seeded From UniProt

complete

GO:0030422

production of siRNA involved in RNA interference

PMID:20133583[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031047

gene silencing by RNA

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0943

P

Seeded From UniProt

complete

GO:0031050

dsRNA fragmentation

PMID:11461699[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031054

pre-miRNA processing

PMID:15531879[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031054

pre-miRNA processing

PMID:19734881[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035262

gonad morphogenesis

PMID:11486053[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040034

regulation of development, heterochronic

PMID:11641272[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00239410

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000999
InterPro:IPR011907

P

Seeded From UniProt

complete

GO:0090501

RNA phosphodiester bond hydrolysis

PMID:19734881[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0090501

RNA phosphodiester bond hydrolysis

PMID:20223951[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000999
InterPro:IPR011907

P

Seeded From UniProt

complete

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005034

P

Seeded From UniProt

complete

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

PMID:19734881[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

PMID:20223951[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:2000636

positive regulation of primary miRNA processing

PMID:15531879[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Ketting, RF et al. (2001) Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15 2654-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Nakagawa, A et al. (2010) Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science 328 327-34 PubMed GONUTS page
  3. 3.0 3.1 Grishok, A et al. (2001) Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106 23-34 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Chatterjee, S & Grosshans, H (2009) Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature 461 546-9 PubMed GONUTS page
  5. 5.0 5.1 Drake, M et al. (2014) A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans. Dev. Cell 31 614-28 PubMed GONUTS page
  6. 6.0 6.1 Vasale, JJ et al. (2010) Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. Proc. Natl. Acad. Sci. U.S.A. 107 3582-7 PubMed GONUTS page
  7. Duchaine, TF et al. (2006) Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell 124 343-54 PubMed GONUTS page
  8. Juang, BT et al. (2013) Endogenous nuclear RNAi mediates behavioral adaptation to odor. Cell 154 1010-22 PubMed GONUTS page
  9. 9.0 9.1 Denli, AM et al. (2004) Processing of primary microRNAs by the Microprocessor complex. Nature 432 231-5 PubMed GONUTS page
  10. Knight, SW & Bass, BL (2001) A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 293 2269-71 PubMed GONUTS page