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YEAST:XRS2
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | XRS2 | |
| Protein Name(s) | DNA repair protein XRS2 | |
| External Links | ||
| UniProt | P33301 | |
| EMBL | L22856 U28373 X80642 BK006938 | |
| PIR | S61164 | |
| RefSeq | NP_010657.3 | |
| ProteinModelPortal | P33301 | |
| BioGrid | 32428 | |
| DIP | DIP-2420N | |
| IntAct | P33301 | |
| MINT | MINT-679297 | |
| iPTMnet | P33301 | |
| MaxQB | P33301 | |
| PRIDE | P33301 | |
| EnsemblFungi | YDR369C | |
| GeneID | 851975 | |
| KEGG | sce:YDR369C | |
| EuPathDB | FungiDB:YDR369C | |
| SGD | S000002777 | |
| InParanoid | P33301 | |
| KO | K10868 | |
| OMA | ACNDINI | |
| OrthoDB | EOG092C0KCP | |
| BioCyc | YEAST:G3O-29919-MONOMER | |
| Reactome | [www.reactome.org/content/detail/R-SCE-912446 R-SCE-912446] | |
| PRO | PR:P33301 | |
| Proteomes | UP000002311 | |
| GO | GO:0030870 GO:0005654 GO:0005634 GO:0003677 GO:0003691 GO:0051880 GO:0030674 GO:0043047 GO:0042162 GO:0006284 GO:0006303 GO:0035753 GO:0042138 GO:0097552 GO:0030435 GO:0000723 | |
| Gene3D | 2.60.200.20 | |
| InterPro | IPR000253 IPR008984 | |
| Pfam | PF00498 | |
| SUPFAM | SSF49879 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006303 |
double-strand break repair via nonhomologous end joining |
ECO:0000315 |
P |
in the absence Xrs2, it won't result NHEJ (figure 2E) |
complete | |||||
| GO:0006303 |
double-strand break repair via nonhomologous end joining |
ECO:0000315 |
P |
Figure 2 shows Xrs2 is Required for End Joining and Tel1 Signaling Functions of the MRX Complex in Saccharomyces cerevisiae |
complete | |||||
|
involved_in |
GO:0035753 |
maintenance of DNA trinucleotide repeats |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000723 |
telomere maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006303 |
double-strand break repair via nonhomologous end joining |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097552 |
mitochondrial double-strand break repair via homologous recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051880 |
G-quadruplex DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043047 |
single-stranded telomeric DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042162 |
telomeric DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042138 |
meiotic DNA double-strand break formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030870 |
Mre11 complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030870 |
Mre11 complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030674 |
protein binding, bridging |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030435 |
sporulation resulting in formation of a cellular spore |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006303 |
double-strand break repair via nonhomologous end joining |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000000013 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003691 |
double-stranded telomeric DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000723 |
telomere maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-SCE-981784 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051321 |
meiotic cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kobayashi, Y (2012) [Effect of adding phenylephrine on spinal anesthesia with tetracaine in elderly patients]. Masui 61 579-82 PubMed GONUTS page
- ↑ Oh, J et al. (2016) Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex. Mol. Cell 64 405-415 PubMed GONUTS page
- ↑ Ye, Y et al. (2016) The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination. DNA Repair (Amst.) 43 1-8 PubMed GONUTS page
- ↑ 4.0 4.1 Boulton, SJ & Jackson, SP (1998) Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17 1819-28 PubMed GONUTS page
- ↑ Kalifa, L et al. (2012) Mitochondrial genome maintenance: roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae. Genetics 190 951-64 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Ghosal, G & Muniyappa, K (2007) The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity. J. Mol. Biol. 372 864-82 PubMed GONUTS page
- ↑ Takata, H et al. (2005) Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae. Mol. Cell 17 573-83 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Tsukamoto, Y et al. (2005) Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination. Mol. Biol. Cell 16 597-608 PubMed GONUTS page
- ↑ 9.0 9.1 Usui, T et al. (1998) Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95 705-16 PubMed GONUTS page
- ↑ 10.0 10.1 Trujillo, KM et al. (2003) Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends. J. Biol. Chem. 278 48957-64 PubMed GONUTS page
- ↑ Wilson, TE (2002) A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio. Genetics 162 677-88 PubMed GONUTS page
- ↑ 12.0 12.1 Steininger, S et al. (2010) A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair. Nucleic Acids Res. 38 1853-65 PubMed GONUTS page
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