GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:9845372
| Citation |
Usui, T, Ohta, T, Oshiumi, H, Tomizawa, J, Ogawa, H and Ogawa, T (1998) Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95:705-16 |
|---|---|
| Abstract |
Meiotic recombination of S. cerevisiae contains two temporally coupled processes, formation and processing of double-strand breaks (DSBs). Mre11 forms a complex with Rad50 and Xrs2, acting as the binding core, and participates in DSB processing. Although these proteins are also involved in DSB formation, Mre11 is not necessarily holding them. The C-terminal region of Mre11 is required only for DSB formation and binds to some meiotic proteins. The N-terminal half specifies nuclease activities that are collectively required for DSB processing. Mre11 has a DNA-binding site for DSB formation and another site for DSB processing. It has two regions to bind to Rad50. Mre11 repairs methyl methanesulfonate-induced DSBs by reactions that require the nuclease activities and those that do not. |
| Links | |
| Keywords |
Animals; Chromosomes, Fungal; DNA Repair; DNA-Binding Proteins; Endodeoxyribonucleases; Exodeoxyribonucleases; Fungal Proteins/metabolism; Fungal Proteins/physiology; Guinea Pigs; Meiosis/genetics; Rabbits; Recombination, Genetic; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
