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YEAST:TOR2

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) TOR2 (synonyms: DRR2, TSC14)
Protein Name(s) Serine/threonine-protein kinase TOR2

Dominant rapamycin resistance protein 2 Phosphatidylinositol 4-kinase TOR2 PI4-kinase TOR2 PI4K TOR2 PtdIns-4-kinase TOR2 Target of rapamycin kinase 2 Temperature-sensitive CSG2 suppressor protein 14

External Links
UniProt P32600
EMBL X71416
Z28203
BK006944
PIR S38040
RefSeq NP_012719.2
ProteinModelPortal P32600
SMR P32600
BioGrid 33920
DIP DIP-2332N
IntAct P32600
MINT MINT-2843476
iPTMnet P32600
MaxQB P32600
PeptideAtlas P32600
EnsemblFungi [example_ID YKL203C]
GeneID 853632
KEGG sce:YKL203C
EuPathDB FungiDB:YKL203C
SGD S000001686
GeneTree ENSGT00830000128322
HOGENOM HOG000163215
InParanoid P32600
KO K07203
OMA VRCIPVD
OrthoDB EOG7Z3FCR
BioCyc YEAST:G3O-31962-MONOMER
BRENDA 2.7.1.137
Reactome R-SCE-975957
NextBio 974511
PRO PR:P32600
Proteomes UP000002311
GO GO:0005737
GO:0031234
GO:0000329
GO:0005886
GO:0031931
GO:0031932
GO:0004430
GO:0005524
GO:0008144
GO:0004674
GO:0030037
GO:0007010
GO:0006281
GO:0030950
GO:0010507
GO:0045807
GO:2001108
GO:0035025
GO:0006468
GO:0051726
GO:0001558
GO:0042254
GO:0007165
GO:0031929
Gene3D 1.10.1070.11
1.25.10.10
InterPro IPR011989
IPR016024
IPR024585
IPR003152
IPR011009
IPR000403
IPR018936
IPR003151
IPR014009
IPR009076
IPR026683
PANTHER PTHR11139:SF9
Pfam PF11865
PF02259
PF02260
PF00454
PF08771
SMART SM00146
SUPFAM SSF47212
SSF48371
SSF56112
PROSITE PS51189
PS51190
PS00915
PS00916
PS50290

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005634

nucleus

PMID:26912660[1]

ECO:0000314

C

Figure 1E

complete
CACAO 11335

part_of

GO:0005739

mitochondrion

PMID:16823961[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14576278[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1905356

regulation of snRNA pseudouridine synthesis

PMID:27268497[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

PMID:18723607[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:22307609[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(UniProtKB:P12688)

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:22307609[6]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P12688)

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:16055732[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

has_direct_input:(UniProtKB:P18961)

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:16055732[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_direct_input:(UniProtKB:P18961)

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:16055732[7]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(UniProtKB:P18961)

Seeded From UniProt

complete

involved_in

GO:2001108

positive regulation of Rho guanyl-nucleotide exchange factor activity

PMID:9038344[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P51862

P

Seeded From UniProt

complete

involved_in

GO:2001108

positive regulation of Rho guanyl-nucleotide exchange factor activity

PMID:9038344[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045807

positive regulation of endocytosis

PMID:14593073[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042254

ribosome biogenesis

PMID:10198052[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

PMID:9038344[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P06780
UniProtKB:P06781
UniProtKB:P17121
UniProtKB:P51862

P

Seeded From UniProt

complete

involved_in

GO:0035025

positive regulation of Rho protein signal transduction

PMID:9038344[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031932

TORC2 complex

PMID:12408816[11]

ECO:0000353

physical interaction evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031931

TORC1 complex

PMID:12408816[11]

ECO:0000353

physical interaction evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031929

TOR signaling

PMID:8186460[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031929

TOR signaling

PMID:12719473[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031929

TOR signaling

PMID:12408816[11]

ECO:0000305

curator inference used in manual assertion

GO:0031931
GO:0031932

P

Seeded From UniProt

complete

part_of

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

PMID:12631735[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030950

establishment or maintenance of actin cytoskeleton polarity

PMID:12408816[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010507

negative regulation of autophagy

PMID:9461583[15]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003827

P

part_of:(GO:0006995)

Seeded From UniProt

complete

involved_in

GO:0007010

cytoskeleton organization

PMID:9475724[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:10973982[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:16055732[7]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P18961)

Seeded From UniProt

complete

part_of

GO:0000329

fungal-type vacuole membrane

PMID:8846782[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0038202

TORC1 signaling

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0021796
PANTHER:PTN000124327
PomBase:SPBC216.07c
UniProtKB:P42345

P

Seeded From UniProt

complete

part_of

GO:0031932

TORC2 complex

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0021796
PANTHER:PTN000124327
PomBase:SPBC30D10.10c
UniProtKB:P42345
WB:WBGene00002583
dictyBase:DDB_G0281569

C

Seeded From UniProt

complete

part_of

GO:0031931

TORC1 complex

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0021796
MGI:MGI:1928394
PANTHER:PTN000124327
PomBase:SPBC216.07c
RGD:68371
UniProtKB:P42345
WB:WBGene00002583

C

Seeded From UniProt

complete

involved_in

GO:0016242

negative regulation of macroautophagy

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0021796
MGI:MGI:1928394
PANTHER:PTN000124327
UniProtKB:P42345

P

Seeded From UniProt

complete

involved_in

GO:0010507

negative regulation of autophagy

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1928394
PANTHER:PTN000124327
PomBase:SPBC216.07c
RGD:68371
SGD:S000001686
SGD:S000003827
UniProtKB:P42345
UniProtKB:Q9FR53

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0045035
FB:FBgn0053554
MGI:MGI:104779
MGI:MGI:1928394
PANTHER:PTN000124197
RGD:1593265
RGD:68371
SGD:S000000340
SGD:S000001141
SGD:S000003827
UniProtKB:P78527
UniProtKB:Q13315
UniProtKB:Q96Q15
UniProtKB:Q9FR53
UniProtKB:Q9Y4A5
WB:WBGene00000226
WB:WBGene00007028

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1928394
PANTHER:PTN000124327
PomBase:SPBC216.07c
PomBase:SPBC30D10.10c
RGD:68371
SGD:S000001686
SGD:S000003827
UniProtKB:P42345

F

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004430

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026683

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018936
InterPro:IPR036940

F

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009076
InterPro:IPR036738

F

Seeded From UniProt

complete

enables

GO:0004430

1-phosphatidylinositol 4-kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.1.67

F

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

PMID:9475724[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030037

actin filament reorganization involved in cell cycle

PMID:9038344[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:8186460[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001558

regulation of cell growth

PMID:11057898[20]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005773

vacuole

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0926

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0005774

vacuolar membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0271

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Cohen, A et al. (2016) TORC2-Gad8 is found in the nucleus where it interacts with the MBF transcriptional complex to regulate the response to DNA replication stress. J. Biol. Chem. PubMed GONUTS page
  2. ↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  3. ↑ Sickmann, A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100 13207-12 PubMed GONUTS page
  4. ↑ Wu, G et al. (2016) The TOR signaling pathway regulates starvation-induced pseudouridylation of yeast U2 snRNA. RNA 22 1146-52 PubMed GONUTS page
  5. ↑ Sturgill, TW et al. (2008) TOR1 and TOR2 have distinct locations in live cells. Eukaryotic Cell 7 1819-30 PubMed GONUTS page
  6. ↑ 6.0 6.1 Niles, BJ et al. (2012) Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2. Proc. Natl. Acad. Sci. U.S.A. 109 1536-41 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Kamada, Y et al. (2005) Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol. Cell. Biol. 25 7239-48 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Schmidt, A et al. (1997) The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88 531-42 PubMed GONUTS page
  9. ↑ deHart, AK et al. (2003) Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway. Mol. Biol. Cell 14 4676-84 PubMed GONUTS page
  10. ↑ Powers, T & Walter, P (1999) Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol. Biol. Cell 10 987-1000 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 11.3 Loewith, R et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10 457-68 PubMed GONUTS page
  12. ↑ 12.0 12.1 Helliwell, SB et al. (1994) TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol. Biol. Cell 5 105-18 PubMed GONUTS page
  13. ↑ Chen, EJ & Kaiser, CA (2003) LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J. Cell Biol. 161 333-47 PubMed GONUTS page
  14. ↑ Wedaman, KP et al. (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol. Biol. Cell 14 1204-20 PubMed GONUTS page
  15. ↑ Noda, T & Ohsumi, Y (1998) Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273 3963-6 PubMed GONUTS page
  16. ↑ 16.0 16.1 Helliwell, SB et al. (1998) TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148 99-112 PubMed GONUTS page
  17. ↑ Kunz, J et al. (2000) HEAT repeats mediate plasma membrane localization of Tor2p in yeast. J. Biol. Chem. 275 37011-20 PubMed GONUTS page
  18. ↑ Cardenas, ME & Heitman, J (1995) FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. EMBO J. 14 5892-907 PubMed GONUTS page
  19. ↑ 19.0 19.1 19.2 19.3 19.4 19.5 19.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  20. ↑ Schmelzle, T & Hall, MN (2000) TOR, a central controller of cell growth. Cell 103 253-62 PubMed GONUTS page
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