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PMID:9038344
| Citation |
Schmidt, A, Bickle, M, Beck, T and Hall, MN (1997) The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88:531-42 |
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| Abstract |
The Saccharomyces cerevisiae phosphatidylinositol kinase homolog TOR2 is required for organization of the actin cytoskeleton. Overexpression of RHO1 or RHO2, encoding Rho-like GTPases, or ROM2, encoding a GDP/GTP exchange factor for RHO1 and RHO2, suppresses a tor2 mutation. Deletion of SAC7, a gene originally identified as a suppressor of an actin mutation, also suppresses a tor2 mutation. SAC7 is a novel GTPase-activating protein for RHO1. ROM2 exchange activity is reduced in a tor2 mutant, and overexpression of ROM2 lacking its PH domain can no longer suppress a tor2 mutation. Thus, TOR2 signals to the actin cytoskeleton through a GTPase switch composed of RHO1, RHO2, ROM2, and SAC7. TOR2 activates this switch via ROM2, possibly via the ROM2 PH domain. |
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| Keywords |
Cell Cycle Proteins; Cell Division/physiology; Cell Polarity/physiology; Cell Size/physiology; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Fungal Proteins/genetics; Fungal Proteins/metabolism; GTP Phosphohydrolases/genetics; GTP Phosphohydrolases/metabolism; GTP-Binding Proteins/genetics; GTP-Binding Proteins/metabolism; GTPase-Activating Proteins; Gene Expression Regulation, Enzymologic/physiology; Gene Expression Regulation, Fungal/physiology; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate/metabolism; Guanosine Triphosphate/metabolism; Leucine Zippers/physiology; Molecular Sequence Data; Monomeric GTP-Binding Proteins; Mutation/physiology; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor)/genetics; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Plant Proteins/chemistry; Plant Proteins/genetics; Plant Proteins/metabolism; Protein Structure, Tertiary; Proteins/metabolism; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Signal Transduction/physiology; rho GTP-Binding Proteins |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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