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PMID:8186460
| Citation |
Helliwell, SB, Wagner, P, Kunz, J, Deuter-Reinhard, M, Henriquez, R and Hall, MN (1994) TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol. Biol. Cell 5:105-18 |
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| Abstract |
The Saccharomyces cerevisiae genes TOR1 and TOR2 were originally identified by mutations that confer resistance to the immunosuppressant rapamycin. TOR2 was previously shown to encode an essential 282-kDa phosphatidylinositol kinase (PI kinase) homologue. The TOR1 gene product is also a large (281 kDa) PI kinase homologue, with 67% identity to TOR2. TOR1 is not essential, but a TOR1 TOR2 double disruption uniquely confers a cell cycle (G1) arrest as does exposure to rapamycin; disruption of TOR2 alone is lethal but does not cause a cell cycle arrest. TOR1-TOR2 and TOR2-TOR1 hybrids indicate that carboxy-terminal domains of TOR1 and TOR2 containing a lipid kinase sequence motif are interchangeable and therefore functionally equivalent; the other portions of TOR1 and TOR2 are not interchangeable. The TOR1-1 and TOR2-1 mutations, which confer rapamycin resistance, alter the same potential protein kinase C site in the respective protein's lipid kinase domain. Thus, TOR1 and TOR2 are likely similar but not identical, rapamycin-sensitive PI kinases possibly regulated by phosphorylation. TOR1 and TOR2 may be components of a novel signal transduction pathway controlling progression through G1. |
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| Keywords |
1-Phosphatidylinositol 4-Kinase; Amino Acid Sequence; Base Sequence; Cell Cycle/genetics; Cell Cycle Proteins; Drug Resistance, Microbial/genetics; Fungal Proteins/antagonists & inhibitors; Fungal Proteins/chemistry; Fungal Proteins/genetics; Genes, Fungal; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors; Phosphotransferases (Alcohol Group Acceptor)/chemistry; Phosphotransferases (Alcohol Group Acceptor)/genetics; Polyenes/pharmacology; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/drug effects; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sirolimus |
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Significance
Annotations
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